Latest ƙarni na NSAIDs: reviews, jerin farashin

A yawa na pathological canje-canje da faruwa a cikin jiki, tare da zafi. Don magance irin wannan bayyanar cututtuka ɓullo da NSAIDs ko ba-steroidal anti-mai kumburi wakili. Suna da kyau anesthetized, rage ƙonewa, rage kumburi. Duk da haka, da yawa kwayoyi da illa. Wannan ya takaita da yiwuwar su yi amfani da ga wasu marasa lafiya. Modern pharmacology ya ci gaba da latest ƙarni na NSAIDs. Irin wannan kwayoyi suna da yawa m iya haifar da m halayen, amma zama inganci da kwayoyi da zafi.

da tasiri na da manufa na

Abin da shi ne saboda da sakamako na NSAIDs a jiki? Suna aiki a kan cyclooxygenase. Cox yana da biyu isoforms. Kowace daga cikinsu daukawa fitar da ayyuka. Irin wannan enzyme (Cox) Yanã da wani sinadaran dauki sakamakon a arachidonic acid wuce zuwa prostaglandins, thromboxanes da leukotrienes.

Cox-1 ne ke da alhakin samar da prostaglandins. Su kare ciki daga m effects da wani tasiri a kan aiki na platelets, da kuma tasirin da wani canji a koda jini ya kwarara.

Cox-2 ne kullum ba a nan, kuma shi ne mai takamaiman enzyme kumburi hada ta hanyar cytotoxins, kazalika da sauran shiga tsakani.

Irin wannan mataki na NSAIDs kamar yadda hanawa na Cox-1, daukawa a jam'i na gefe-effects.

sabon aukuwa

Shi ne ba wani asirin da cewa shirye-shirye na ƙarni na farko na NSAIDs da wani m sakamako a kan na ciki mucosa. Saboda haka, masana kimiyya sun kafa wata manufa - don rage a ke so effects. wani sabon saki fom da aka ɓullo. A cikin irin wannan formulations da aiki sashi ne a cikin na musamman ambulan. A kwantena da aka yi na irin kayan da cewa ba ta soke a acidic yanayi na ciki. Sun fara durkushe kawai a lokacin da ya buga a cikin Gut. Yana yiwuwa a rage irritating sakamako a kan na ciki mucosa. Duk da haka, inji rauni m gastrointestinal fili ganuwar da aka har yanzu kiyaye su.

Wannan ya sa chemists hada gaba daya sabon fili. Previous magunguna su ne tushen daban-daban inji na mataki. wani sabon ƙarni na NSAIDs halin da zabe sakamako a kan Cox-2, kazalika da hanawa da prostaglandin samar. Wannan ba ka damar isa duk dole effects - analgesic, antipyretic, anti-kumburi. A wannan yanayin, da latest ƙarni na NSAIDs domin rage tasiri a kan jini coagulation, platelet aiki na ciki mucosa.

Anti-mai kumburi sakamako saboda ƙananan permeability na jijiyoyin bugun gini ganuwar, kazalika da rage a samar da wani iri-iri mai kumburi shiga tsakani. Saboda wannan daukan hotuna da aka rage girmanta hangula na jijiya zafi rabe. Tasiri a kan wasu thermoregulatory cibiyoyinsu a cikin kwakwalwa, da damar da latest ƙarni na NSAIDs ne m su runtse da sauran zazzabi.

alamomi

Yadu da aka sani da sakamakon NSAIDs. A tasiri na irin kwayoyi ne da nufin hana ko rage kumburi tsari. Wadannan kwayoyi bayar da wani kyakkyawan antipyretic sakamako. Su effects a jiki za a iya kwatanta ta da sakamako na narcotic analgesics. Bugu da kari, sun samar da wani analgesic, anti-kumburi effects. NSAIDs cinma m sikelin a wani asibiti saitin kuma a rayuwar yau da kullum. A yau shi ne daya daga cikin mafi m likita kwayoyi.

A tabbatacce tasiri aka lura a kan wadannan dalilai:

1. Cututtuka na musculoskeletal tsarin. A daban-daban sprains, bruises, amosanin gabbai magani data ne kawai irreplaceable. NSAIDs amfani a osteochondrosis, kumburi arthropathy, amosanin gabbai. Da miyagun ƙwayoyi yana da anti-mai kumburi effects a scoliosis, herniated fayafai.
2. Ciwo mai tsanani. Shirye-shirye quite nasarar amfani a cikin biliary colic, gynecology cututtuka. Sun kawar da ciwon kai, ko da migraines, koda rashin jin daɗi. NSAIDs an samu nasarar yi amfani ga marasa lafiya a cikin postoperative zamani.
3. High zazzabi. Antipyretic sakamako damar yin amfani da kwayoyi a ailments bambancin yanayi na biyu manya da yara. Wadannan kwayoyi su ne tasiri ko da a wani zazzabi.
4. Thrombus samuwar. NSAIDs ne kwayoyi antiplatelet. Wannan damar da su zuwa nema a ischemia. Su ne mai m gwargwado da ciwon zuciya da kuma bugun jini.

rarrabuwa

Game da shekaru 25 da suka wuce, shi da aka tsara kawai 8 kungiyoyin na NSAIDs. Yau, cewa adadin ya karu zuwa 15. Duk da haka, da ainihin adadi ma da ake kira da likitoci ba su dauka. Bayyana a kasuwa, da sauri lashe tartsatsi shahararsa ta NSAIDs. Shirye-shirye hambararren opioid analgesics. Saboda su, sabanin baya, ba tsokane numfashi da ciki.

A rarrabuwa na NSAIDs ya shafi wani rabo a cikin ƙungiyõyi biyu:

1. Mazan kwayoyi (ƙarni na farko). Wannan category hada da aka sani da kwayoyi, "Tsitramon", "asfirin", "Ibuprofen", "naproxen", "Nurofen", "Voltaren", "Diklak", "diclofenac", "indomethacin", "Movimed", "Phenylbutazone" .
2. New NSAIDs (na biyu ƙarni). A cikin shekaru 15-20 shekaru, pharmacology ya ɓullo da kyau kwarai kayayyakin, kamar "Movalis", "Nimesil", "Nise", "Celebrex" "Arcoxia."

Duk da haka, wannan ba kawai rarrabuwa na NSAIDs. sabon ƙarni kwayoyi kasu kashi ba-acid Kalam kuma acid. Da farko, la'akari da karshen category:

1. Salicylates. Wannan rukunin na kunshe da NSAID kwayoyi, "asfirin", "diflunisal," "Lizinmonoatsetilsalitsilat".
2. Pyrazolidine. Wakilai daga wannan rukuni na kwayoyi ne "phenylbutazone", "azapropazone", "oxyphenbutazone."
3. Oxicams. Wannan shi ne mafi m sabon ƙarni na NSAIDs. List of kwayoyi: "piroxicam" "Meloxicam", "Lornoxicam", "tenoxicam." Magunguna ne ba cheap, amma tasiri a jiki yana da yawa fiye da sauran NSAIDs.
4. Phenylacetic acid Kalam. Irin wannan kungiyar na NSAIDs hada da nufin "diclofenac", "tolmetin," "Indomethacin", "Etodolac", "Sulindac," "Atseklofenak".
5. Formulations anthranilic acid. Babban wakilin wani magani "Mefenaminat".
6. Wajen propionic acid. Wannan category ƙunshi mutane da yawa kyau NSAIDs. List of kwayoyi: "Ibuprofen" "ketoprofen" "benoxaprofen", "fenbufen," "fenoprofen," "tiaprofenic acid", "naproxen", "Flurbiprofen", "pirprofen," "nabumetone".
7. Isonicotinic acid Kalam. Main magani "Amizon".
8. pyrazolone kwayoyi. Don wannan category nasa ne sananne wajen, "Analgin".

By ba acid Kalam hada sulfonamides. Wannan kungiyar hada da miyagun kwayoyi, "Rofecoxib" "Celecoxib", "Nimesulide".

illa

wani sabon ƙarni na NSAIDs aka jera a sama, daban-daban tasiri tasiri a jiki. Duk da haka, ba su shafi aiki na gastrointestinal fili. Bambanta wadannan kwayoyi ne wani m batu: sabon ƙarni na NSAIDs ba su da wani yankunan da sakamako a kan guringuntsi nama.

Duk da haka, ko da irin wannan tasiri wajen iya sa wani adadin a ke so effects. Ya kamata su san, musamman idan da miyagun ƙwayoyi da ake amfani da lokaci mai tsawo.

Babban illa iya sun hada da:

• dizziness.
• drowsiness.
• ciwon kai.
• gajiya.
• zuciya palpitations.
• kara matsa lamba.
• kadan shortness na numfashi;
• bushe tari.
• narkewa kamar cuta.
• gina jiki a cikin fitsari.
• dagagge hanta enzymes.
• fata rash (batu).
• m riƙewa.
• alerji.

A wannan yanayin, ciki mucosa lalacewa ba lura a cikin m na sabon NSAIDs. A kwayoyi ba sa exacerbation na zub da jini ulcers.

Yabo don amfani

A mafi kyau anti-kumburi kwayoyi da phenylacetic acid, salicylates, pirazolidony, oxicams, alkanones, kwayoyi na propionic acid da kuma sulfonamide.

Daga hadin gwiwa zafi mafi yadda ya kamata kashe kwayoyi "Indomethacin", "diclofenac", "Ketoprofen", "Flurbiprofen". Wannan shi ne mafi kyau NSAID a osteochondrosis. A bisa magunguna wanin "ketoprofen" shiri mallaka furta anti-mai kumburi sakamako. na nufin "piroxicam" fall a cikin wannan rukunin.

Tasiri analgesics ne "Ketorolac" kwayoyi "Ketoprofen", "Indomethacin" "Diclofenac".

The shugaban daga cikin latest ƙarni na NSAIDs ya da miyagun ƙwayoyi "Movalis". Wannan kayan aiki da aka jiyar da su yi amfani da wani dogon lokaci. Anti-mai kumburi kwayoyi ne tasiri analogs kwayoyi "Movasin", "Mirloks", "Lem", "Artrozan", "Melox", "Melbek", "Mesipol" da "Amelotex".

Drug "Movalis"

Wannan magani ne samuwa kamar yadda Allunan, suppositories da rectal bayani ga intramuscular gwamnati. Agent tana nufin Kalam enolovoy acid. Halin m miyagun ƙwayoyi analgesic da antipyretic Properties. An gano cewa, a kusan duk kumburi tafiyar matakai da magani kawo wani amfani tasiri.

Alamomi ga yin amfani da kwayoyi ne osteoarthritis, ankylosing spondylitis, rheumatoid amosanin gabbai.

Duk da haka, ka sani cewa akwai contraindications da jamiái sami:

• hypersensitivity zuwa wani bangaren na magani.
• ulcerous cuta a cikin m mataki.
• tsanani na koda hanawa.
• miki zub da jini;
• mai tsanani hanta gazawar;
• ciki, nono-ciyar;
• m zuciya rashin cin nasara.

Kada ku riƙi da miyagun ƙwayoyi yara har zuwa shekaru 12.

Adult marasa lafiya da suke kamu osteoarthritis, shawarar da kullum ta hanyar 7.5 MG. Idan ya cancanta, wannan kashi iya karu da sau 2.

A rheumatoid amosanin gabbai da kuma ankylosing spondylitis kullum kullum ne 15 MG.

Extreme kula tafii da miyagun ƙwayoyi ga marasa lafiya da suke yiwuwa zuwa fitowan da illa. Mutanen da suka bayyana koda insufficiency da kuma wanda ya kasance a kan hemodialysis, ya kamata dauki ba fiye da 7.5 MG lokacin da rana.

A kudin da miyagun ƙwayoyi "Movalis" a allunan 7.5 MG, № 20 ne 502 rubles.

Mai amfani da ra'ayi game da magani

Reviews na mutane da yawa suka ne batun ciwo mai tsanani, ya nuna cewa da miyagun ƙwayoyi "Movalis" - mafi kyau ga kayan aiki da dogon lokacin da amfani. Yana da kyau a jure da marasa lafiya. Bugu da kari, ta dogon gaban a jikin sa ya yiwu guda kashi na magani. A muhimmanci sosai factor, bisa ga yawan masu amfani da, shi ne don kare guringuntsi, saboda miyagun ƙwayoyi yana da wani mummunan tasiri a kan su. Yana da matukar muhimmanci ga marasa lafiya da suke yi amfani da wajen a osteochondrosis, arthrosis.

Bugu da kari, da miyagun ƙwayoyi ne m ceton daga daban-daban sha raɗaɗin - ciwon hakori, ciwon kai. Da kulawa ta musamman ga marasa lafiya a kan wani m jerin illa. Duk da yake karbar wani NSAID magani duk da gargadin da manufacturer, ba wuya m sakamakon.

Drug "Celecoxib"

A mataki na wannan kayan aiki ne da nufin alleviating da yanayin haƙuri da osteochondrosis da arthrosis. Da miyagun ƙwayoyi ne daidai gusar zafi, yadda ya kamata sauqaqa da kumburi tsari. Illa a kan narkewa kamar tsarin da aka gano.

Alamomi ga yin amfani da ba a manual ne:

• psoriatic amosanin gabbai .
• osteoarthritis.
• rheumatoid amosanin gabbai.
• ankylosing spondylitis.

Wannan halitta na da yawan contraindications. Bugu da kari, da miyagun ƙwayoyi ba a yi nufi ga yara a karkashin shekaru 18. Musamman hankali ya kamata a lura ga mutane da suke da zuciya rashin cin nasara kamu a matsayin hanyar kara laulayi ruwa riƙewa.

A kudin da miyagun ƙwayoyi dabam dangane da kunshin, a yankin na 500-800 rubles.

mabukaci ra'ayi

Quite da sabanin sake dubawa game da wannan magani. Wasu marasa lafiya saboda wannan makaman zai iya lashe hadin gwiwa zafi. Sauran marasa lafiya ce cewa da miyagun ƙwayoyi bai taimaka. Saboda haka, nufin wannan ba ko da yaushe tasiri.

Bugu da kari, ya kamata mu ba yi da miyagun ƙwayoyi da kansu. A wasu kasashen Turai da wannan magani da aka haramta, saboda shi yana da sakamako na cardiotoxicity, wanda shi ne isa ga zuciya raunana.

Drug "Nimesulide"

Wannan magani ba kawai yana da anti-mai kumburi da antipain sakamako. Yana nufin yana da antioxidant Properties cewa hana miyagun ƙwayoyi abubuwa da hallaka guringuntsi da collagen zaruruwa.

Amfani da magani ga:

• amosanin gabbai.
• amosanin gabbai.
• osteoarthritis.
• myalgia.
• arthralgia.
• bursitis.
• zazzabi.
• daban-daban zafi syndromes.

A wannan yanayin, da analgesic sakamako daga cikin miyagun ƙwayoyi samar da sauri. Yawanci, da haƙuri ji taimako a cikin minti 20 bayan ingestion. Shi ya sa wannan kayan aiki ne sosai tasiri ga m paroxysmal zafi.

Kusan ko da yaushe, da miyagun ƙwayoyi da aka kyau jure da marasa lafiya. Amma wani lokacin, kana iya samun illa kamar juwa ko jiri, drowsiness, ciwon kai, tashin zuciya, ƙwannafi, hematuria, oliguria, urticaria.

A kayan aiki ba a yarda ya sami mata masu ciki da yara har zuwa shekaru 12. Special kula tafii da miyagun ƙwayoyi "Nimesulide" mutanen da suka gani hauhawar jini, illa koda aiki, da hangen nesa ko zuciya.

Price kwayoyi a kan talakawan 76,9 rubles.

Abin da yi masu amfani?

Reviews shiri ne kusan ko da yaushe m. Tun lokacin da miyagun ƙwayoyi ne daidai sauqaqa zafi da rage zazzabi, mai girma ya yi yãki kumburi.

Mutane da yawa marasa lafiya bayar da rahoton cewa bayyanar cututtuka taimako na faruwa da sauri isa, da kuma tsawon lokaci da ta mataki ne game da takwas hours.

Excellent kayan aiki daidai gusar da hakori, traumatic, arthritic zafi. Da miyagun ƙwayoyi iya taimaka rashin jin daɗi lalacewa ta hanyar jijiya entrapment.

Drug "Ksefokam"

Wannan magani ne kunshe a cikin kungiyar oxicams. Wannan rukuni na NSAID ya bambanta da ya karu rabin-rai, sakamakon shafe tsawon miyagun ƙwayoyi daukan hotuna. Yana rage muhimmanci da mita na samun medicament. Saboda haka, hadarin illa an rage.

Drug "Ksefokam" ne daga cikin mafi girman ikon sadar da zafi. Its analgesic effects a kan karfi bayyananen m zuwa morphine. Duk da haka, sabanin karshen, da kayan aiki ne ba jaraba kuma ba zai tasiri a tsakiya m tsarin.

A lokacin gwaji, sai aka fahimci cewa da miyagun ƙwayoyi sauqaqa zafi for 12 hours.

A kudin da miyagun ƙwayoyi a kwamfutar hannu tsari (8 MG) № shiryawa 10 ne 205 rubles.

Drug "Rofecoxib"

Da miyagun ƙwayoyi yana da anti-mai kumburi analgesic, antipyretic kuma anti-edematous sakamako. Sanya tasiri wajen domin wadannan ailments:

• kullum periarthritis.
• rheumatoid amosanin gabbai.
• tendonitis.
• bursitis.
• agara raunin da jijiyoyin, tsokoki.

Shi ya ishe su yadda ya kamata kawar da miyagun ƙwayoyi "Rofecoxib" iri-iri mai raɗaɗi cututtuka sa ta neuralgia, osteochondrosis, bagade. Yana nufin daidai sauqaqa lumbago, ciwon hakori, radicular ciwo.

A miyagun ƙwayoyi ya kamata ba zama batun yarda da marasa lafiya da asma, bayan fama da ciwon zuciya da shanyewar jiki. Ba lallai ba ne a yi amfani da shi, da kuma mutane da oncological cututtuka, hauhawar jini da kuma atherosclerosis. Da miyagun ƙwayoyi da aka haramta ga yara a karkashin shekaru 12. Bugu da kari, kafin ka yi amfani da shi ne bu mai kyau zuwa hankali la'akari da yiwu illa.

Drug "Parecoxib"

Wannan shi ne mai kyau hanyar da za a rage kumburi amsa da bayar da tasu gudunmuwar akan rage ji na ƙwarai daga zafi rabe. Da miyagun ƙwayoyi ne a bukatar ga marasa lafiya jurewa tiyata.

Yana gusar zafi syndromes na matsakaici to mai tsanani tsanani. Gudanar bayan total kwantangwalo da gwiwa sauyawa, hysterectomy, jijiyoyin zuciya jijiya kewaye tiyata, a yi amfani da hakori yi.

Sashi gyara ne zalla mutum. Ya dogara da na asibiti halin da ake ciki da kuma nuni. Yara a karkashin shekaru 18 da magani ba a yi nufin.

Drug "Arcoxia"

A magani yana da wani sunan - "Etorikoksib". A wajen da aka halin high antiinflammatory, analgesic Properties. A shirye-shiryen inganta hanawa na zafi turu.

Marasa lafiya da cututtuka na musculoskeletal tsarin da taimakon da wannan kayan aiki rabu da safe stiffness. Sun inganta hadin gwiwa motsi, rage tsanani da ciwon kumburi, daidai kuranye da zafi. A kan samun da warkewa tasirin ne ke faruwa a cikin ashirin da hudu da minti. The aiki miyagun ƙwayoyi abu ne da tunawa da jini. A shirye-shiryen da aka halin high bioavailability. Wannan Fihirisar ne 100%.

A kashi na miyagun ƙwayoyi za a iya wajabta kawai da likita. Yana kullum jeri daga 60 MG zuwa 120 MG ga kwana.

Da miyagun ƙwayoyi ba a yi nufi ga yin amfani da mata masu ciki da yara har zuwa shekaru 16.

ƙarshe

Modern pharmacology ba yana tsaye har yanzu. Development of sabon, mafi tasiri NSAIDs. List of wasu fiye da wani sabon ƙarni na kwayoyi, sama, ba ka damar zabi mafi kyau ga kayan aiki da wani pathologies. Duk da haka, ka sani cewa wadannan kwayoyi ba su iya warkar da cutar. Bã su da kawai wani anti-mai kumburi da analgesic sakamako.