"Orgalutran": da wani umurni description, analogs da kuma sake dubawa

A vitro hadi - da hanya ne sosai rikitarwa. Yana bada wata dama ga mata da yawa fama da rashin haihuwa, samun ciki. A lokacin IVF yin amfani da mahara kwayoyi. Da aka fi kunna magani "Orgalutran." Umarnin ga shi ya bayyana a cikin daki-daki cikin gabatarwar da dabara na da miyagun ƙwayoyi da kuma yayi kashedin na yiwu sakamakon.

A abun da ke ciki da kuma nau'i na samarwa

Yana yayi kashedin da bukatar tuntubar wani gwani kafin reproductologist "Orgalutran" Drug Administration umarnin. Samfurin Form - 0.5 ml sirinji tare da wani bayani ga gwamnati don subcutaneous injections. Ya ƙunshi game da 250 MG na aiki abu ganirelix, wanda aka samar a cikin nau'i na acetate. Daga cikin adjuvants kunna mannitol, glacial acetic acid, distilled ruwa. Cushe a cikin wani kwali akwatin a kan daya ko biyar yarwa syringes magani "Orgalutran." Umarnin ga shi ya zo, kuma ya bayyana duk nuances na aikace-aikace na da miyagun ƙwayoyi.

A pharmacological effects da miyagun ƙwayoyi a jiki

Medicine "Orgalutran" (mai amfani da cikakken kwatanci yadda allurar magani data) tana nufin wani tsoka mai amsa sigina antagonists na gonadotropin-sakewa hormone. Ya taimaka wajen waƙa da samar da gonadotropins LH da FSH. Yana slows mugunya LH da FSH da pituitary gland shine yake. Idan ba a baya an yi ruri daga wadannan ji ba gani, da hanawa da mugunya pituitary aiki auku kusan nan da nan bayan gwamnati da miyagun ƙwayoyi. Wannan sakamako da aka kiyaye ko'ina cikin warkewa lokaci.

Drug nazari a kan mace sa kai ya nuna cewa gwamnati na da yawa kwayoyi rage maida hankali 0.25 MG FSH, LH da oestradiol a cikin jini bayan 74, 32 da kuma kashi 25, bi da bi, wanda aka samu bayan 4, 8 da kuma 16 hours bayan allura. Domin kwanaki biyu bayan gwamnati da hormone bangaren ya zama Madogararsa.

A nufin duration na warkewa hanya tare da kullum gwamnati na injections "Orgalutran" a wani adadin 0.25 MG / rana zuwa waƙa ovulation ruri ne kwanaki biyar. A tsakãtsaki karuwa a LH periodicity (sama 10 iu / L), tare da wani karuwa a progesterone ciki (sama 1 ng / ml) ne 1.2%, wanda shi ne 0.8% a gwargwado ga GnRH agonists.

Kafin fara jiyya, "Orgalutranom" kafin rana ta shida na ruri magunguna ovarian gonadotropin hali a matan da suka ƙãra ovarian halayen faruwa karuwa a LH. Development of LH aka mur kusan nan da nan bayan da farko yi amfani a cikin wannan rukuni na marasa lafiya, "Orgalutran."

alamomi

Yana bada sakamakon tabbatacce a lokacin IVF miyagun ƙwayoyi "Orgalutran." Umarnin da alamomi ga yin amfani da bada shawarar yin amfani da wannan magani don hana karuwa a luteinizing hormone (LH) a cikin mata cewa suke yi sa ido ovarian hyperstimulation yin amfani da ƙarin haihuwa fasahar.

Wannan ya hada har da musamman rashin haihuwa magani shirye-shirye, wanda sukan hade tare da recombinant follicle stimulating hormone (FSH). A cikin wadannan lokuta shafi kawai a kan takardar sayen magani hormonal wakili "Orgalutran." Guide da cikakken kwatanci na tanadi da miyagun ƙwayoyi.

contraindications

Lokacin da hypersensitivity zuwa aiki abu da kuma karin abubuwa ta haramta gudanar injections "Orgalutran" shirye-shiryen koyar da manual. Da miyagun ƙwayoyi ba a sanya tare da karin ji na ƙwarai to gonadotropin-sakewa hormone da abubuwa analogous cikinta. Ban da yin amfani da miyagun ƙwayoyi ne cututtuka na hanta da koda sashin jiki, dake a cikin matsakaici to mai tsanani matakai na raya kasa. Yana gargaɗin cewa shi ba a amfani da lokacin daukar ciki da kuma lactation miyagun ƙwayoyi "Orgalutran" wa'azi da shi. Contraindications magana game da inadmissibility da miyagun ƙwayoyi a yara.

Medicine "Orgalutran": umarnin don amfani da

Wannan magani ne izini ga rubũta kawai haihuwa tsarin, da ciwon mai girma kwarewa. Kallo na ovarian hyperstimulation, wanda aka gudanar da amfani da FSH, za a fara a biyu ko na uku ranar haila. Allura na 0.25 MG ba subcutaneously sau daya a kowace rana. Suna sanya daga rana ta shida na yin amfani da FSH. Idan akwai wani ƙara ruri daga ovarian martani, domin ya hana jinkiri a kara index LH far "Orgalutranom" za'ayi a kan rana ta biyar a lokacin da yin amfani da FSH magunguna. Idan akwai wani jinkirin follicular ci gaba, shi ne mai yiwuwa a gudanar da wani gabatarwar "Orgalutran" bayani daga baya.

FSH kwayoyi da kuma "Orgalutran" ya kamata a yi amfani a lokaci guda. Su ba za a iya gauraye da juna a daya sirinji. Wadannan injections suna sanya a fagage daban-daban na jiki. Sashi kayan aikin FSH zabi akayi daban-daban ga kowane haƙuri. A shi rinjayar da size da kuma yawan follicles ci gaba. Ba lallai ba ne don la'akari da abun ciki na estradiol a cikin jini. "Orgalutran" gudanar har sai wani da ake buƙata yawan preovulatory follicles. Cimma karshe ripening gwamnati shirye-shirye na mutum chorionic gonadotropin.

Biya da hankali ga lokaci na tukar tumbi da aiki abu, lura da cewa tazara tsakanin injections "Orgalutran" shiri ya kamata ba fiye da 30 hours, tun da tazara tsakanin biyu na iya faruwa farkon ganiya LH. Saboda haka, gwamnati "Orgalutran" da safe, shi wajibi ne don ci gaba da bayanai miyagun ƙwayoyi far a kan lokaci lokaci na yin amfani da gonadotropin. Wajibi ne a yi la'akari da rana a lokacin da akwai qaddamarwa na ovulation. Tare da gabatarwar "Orgalutran" a cikin biyu da rabi na rana, sa da miyagun ƙwayoyi karshe lokaci da rana da rana kafin qaddamarwa na ovulation.

Da miyagun ƙwayoyi aka dauke su gaba daya lafiya kuma yana da isasshen yi ga wa] annan mutanen sun halartar da yawa warkewa hawan keke. Safety net yi luteal lokaci na hanya amfani a rasa haihuwa asibitin.

Drug "Orgalutran" gudanar subcutaneously kawai. Domin allura, shi ne kyawawa a zabi femoral yankin. Domin kauce wa lipoatrophy, wuraren ga allura ya kamata a canza. Magani da za a iya gudanar da shi kadai ba, amma bisa sharadin cewa samu cikakken umarnin daga likita. Kafin ka shigar da shirye-shiryen, kana bukatar ka duba bayani. Ya kamata a yi m launi da kuma ba ya dauke da wani impurities. A ranar karewa da kuma rashin iya ajiya samfurin ba za a iya amfani da su.

Kafin allura kamata wanke hannuwansu da sabulu da kuma fata, domin gabatar da allura, shi wajibi ne don aiwatar da barasa. The m hula dole ne a cire daga cikin allura. A fata ya kamata a clamped a cikin Musulunci tsakanin yatsa da kuma forefinger, da allura da aka positioned a wani kwana na 45 ° C zuwa ta surface. Don tabbatar da wuri daga cikin allura, kana bukatar kadan Pull a kan plunger da kuma gani, ba ya bayyana a cikin sirinji jini. Ta bayyanar nuna shigar azzakari cikin farji daga cikin allura a cikin jini jirgin ruwa. A wannan yanayin, da miyagun ƙwayoyi gudanar da aka haramta. Ya kamata sarrafa allura da sirinji da hašawa zuwa ga allura zone swab moistened yalwa barasa ga 'yan mintoci. Saka da miyagun ƙwayoyi kowane lokaci wani sabon sirinji. Idan da allura tana wurinta daidai, a wani jinkirin taki da kuma tare da wannan} o} arin ya zama matsa lamba a kan fistan. Wannan hanya na gwamnati ba sa fata lalacewa.

Bayan allura da allura da sauri cire da kuma amfani da allura zone da barasa swab. Sirinji sau ɗaya kawai za a iya amfani da su. Idan alura lokaci da aka rasa, shi ya kamata a sami wani harbi da zaran mace tunani game da shi. Ba za ka iya shiga a biyu sashi na miyagun ƙwayoyi rama domin a rasa allura. Idan bata lokaci a cikin gabatarwar da miyagun ƙwayoyi ne fiye da awowi shida, da kuma lokacin tsakanin injections - fiye da talatin hours, da mãsu haƙuri a kowane damar Dole ne a shigar da miyagun ƙwayoyi da kuma nemi shawara daga likitan.

illa

Yana gargaɗin cewa akwai iya zama m halayen a allura site, "Orgalutran" shiri umarnin (photo na miyagun ƙwayoyi za ka iya ganin sama). Kamar yadda mai mulkin, shi ne redness, kumburi da kuma itching. M halayen gwada sa'a daya bayan allura. Daga lokaci zuwa lokaci akwai wani janar wani rauni, kurji a kan fata, kumburi da fuska da kuma wahala a numfashi. Iya worsen yanayi kamar eczema, hanyar da ciwon kai, tashin zuciya. Wasu daga cikin mummunan cututtuka dangantawa da gonadotropin far, wanda aka gudanar a ovarian hyperstimulation. Yawanci, wannan zafi a cikin pelvic yankin, ectopic ciki, ciki distention, ovarian hyperstimulation ciwo.

tsõratar

Mata suna predisposed zuwa allergies, kana bukatar ka yi hankali a lokacin da ka yi amfani da "Orgalutran" miyagun ƙwayoyi. Umarnin da bayanin irin shirye-shiryen da ka yi gargaɗi da cewa hypersensitivity zuwa sinadaran backlash nuna nan da nan bayan da farko allura. Drug marufi da aka hada da roba latex, zai iya tsokana wani rashin lafiyan dauki.

Amfani da kwayoyi "Orgalutran" yawanci ci gaba har zuwa wani so yawan preovulatory follicles. Su karshe maturation aka samu da yin amfani da mutum chorionic gonadotropin. Biya da hankali ga rabin rayuwata na aiki abu, mun lura cewa tazara tsakanin gwamnati da miyagun ƙwayoyi kada ta kasance fiye da 30 hours. Wannan yanayin ya shafi co-gwamnati "Orgalutran" da kuma injections na hCG. Idan ba ka cika tare da wannan mulkin, da LH ganiya iya faruwa prematurely. Amfani injections "Orgalutran" da safe shi ya kamata a ci gaba har sai da rana ta hCG gwamnati, ciki har da nasa. Lokacin da yamma gwamnati da miyagun ƙwayoyi kashi amfani karshe dare kafin rana ba wadda ta gabãta na aikace-aikace na hCG.

Maimaita magani far ne kawai za'ayi bayan wani kima da tasiri na magani da kuma hadarin m. A lokacin ovulation ruri wani lokacin bayyana ovarian hyperstimulation ciwo. Da yiwuwar wannan cuta ya kamata a yi la'akari da ko da yaushe a karkashin lura da gonadotropins. Idan ovarian hyperstimulation ciwo aka bayyana a cikin matsakaici da kuma mai tsanani matakai na raya kasa, da m magani ne amfani da gabatarwar a cikin jijiya da kuma colloidal electrolyte mafita, kazalika da heparin. Wannan far ne da za'ayi a kan da dama kwana.

Da miyagun ƙwayoyi ne mai lafiya don amfani, evidenced da yawa preclinical gwaji cewa sun mayar da hankali kan nazarin genotoxicity da yawan guba. Teratogenic kamar yadda magani ba ya nuna. A tasiri a matsayin jami'an tsaro gwamnati na medicament, ba a kafa a mata ciwon nauyi wucewa 90 kg, ko kasa da 50 kg.

Yiwuwar nakasar malformations a tayin lokacin da ta amfani da taimaka haihuwa fasahar ne ba yawa ya fi yadda ya saba ganewa na yaro. Idan akwai malformations, mafi sau da yawa sun dogara ne a kan mutum halaye na iyaye. Da zarar ART ne ko da yaushe wani hadarin a mahara ciki. A kai tsaye mahada tsakanin Yiwuwar faru na lahani kuma da yin amfani da GnRH antagonists ba.

Yana da muhimmanci a vitro hadi a dace hanya zuwa ga gudanar da wani duban dan tayi jarrabawa, kamar yadda a cikin mata da Tubal Pathology hadarin ectopic ciki ne babban isa. Yana yayi kashedin cewa ba za ka iya amfani da bayan ƙarewar kwanan wanda shi ne shekaru biyu, da miyagun ƙwayoyi "Orgalutran" wa'azi da shi. Storage magunguna ya kamata a bushe, tattarã daga rana da kuma fita daga isar yara. Da yawan zafin jiki na bayani ajiya yanayin for injections jeri daga 2 zuwa 30 ° C.

kudin na

Ba kowane kantin magani za a iya samu miyagun ƙwayoyi "Orgalutran." Umarnin da bayanin da miyagun ƙwayoyi yayi kashedin cewa da miyagun ƙwayoyi ne mai iko hormone, sabili da haka saki daga Pharmacy tsananin a kan takardar sayen magani. A talakawan farashin da fakitin biyar vials shawagi a kusa da 6000-7000 rubles. Daya vial Kudinsa 1700-2200 rubles.

analogs

Notes cewa a lokacin da illa bayyana soke amfani da "Orgalutran" shiri umarnin. Analogs iya maye gurbin shi, amma da suka kamata a zaba ne kawai da wani likita idan ya cancanta. A magani, akwai daya kawai analogue - shi ne "Tsetrotid". A kudin daya sirinji ne 1200 rubles, bakwai - 8500-10000 rubles. Nuna a canza a Switzerland.

shedu

Yana nuna cewa taimaka ciki a lokacin IVF miyagun ƙwayoyi "Orgalutran" wa'azi da shi. Reviews ce cewa magani aiki mai girma da kuma kawar da fitarwa aiwatar da kwai follicles. A medicament aka kunsasshen a mai tsananin tsare allurai, shi yana da wani bakin ciki allura, yin wani harbi da aka kusan ba ya ji, kuma hanya ga gwamnati ta halin kaka ba tare da busa, da bruising, amma bisa sharadin cewa duk abin da aka yi yadda ya kamata, bisa ga umarnin.

Daga cikin korau al'amurran da haƙuri da zafi batu allura shafin. Ni ba farin ciki da kuma cewa da miyagun ƙwayoyi ne wuya saya a yau da kullum kantin magani, da kuma a mafi yawan mata bayar da sayan asibiti. Wasu ba injections sa wani karu a ci. Mafi m tare da babban farashi da miyagun ƙwayoyi, amma suka ce cewa yana da daraja da shi.