Syndrome Churg-Strauss: Bayyanar cututtuka da kuma Jiyya

Sau da yawa sosai, babu fiye da 3 lokuta da 100 mutane dubu, sami musamman irin kumburi jini ko vasculitis kira Churg-Strauss ciwo. Yana za a iya samu bisa ga Turanci pronunciation na sunan "Churg-Strauss ciwo." Gano shi da kansa daga juna sau daya cikin biyu masana kimiyya a shekarar 1951. Har yanzu, akwai cikakken m data cewa yana sa irin wannan vasculitis ko arteritis, wanda a ka'ida ne guda. Dogara tabbatar da cewa shi zai iya faruwa a kowane jiki cewa suna hade da kananan da kuma matsakaici-sized jini, wato, kusan duk jikin mutum.

A likita definition cuta

Daban-daban kafofin iya saduwa da dama formulations, abin da yake tricky Churg-Strauss ciwo. Mun bayar da mafi dace wa da pathogenesis da etiology. Yana necrotizing vasculitis (vasculitis), capillaries, venules da arterioles a tare da fuka da kuma eosinophilia, kuma granulomatous da eosinophilic kumburi da numfashi tsarin.

Me ake nufi da necrotizing? Lokacin da akwai kumburi kananan jini, su ne kadan a diamita lumens sauri zama gidan ya toshe, sakamakon lalace jini ya kwarara zuwa kewaye kyallen takarda. A sakamakon haka, wadannan shafukan da kuma tasoshin kansu aka kashe, shi dai itace su necrosis.

Me ake nufi da eosinophilia? A cikin jini daga cikin mutane su ne farin jini Kwayoyin ko leukocytes da eosinophils daga gare su, don haka ya kira, domin suna stained da eosin. Kullum wadannan leukocytes ya zama har zuwa 350 raka'a. 1 l. Idan akwai karin magana game da eosinophilia, wanda aka dauke su wani alama na da yawa cututtuka da kuma Churg-Strauss ciwo da.

Me ake nufi da granulomatous? Lokacin da nodules (granules) an kafa a kumburi, suka ce cewa irin wannan kumburi granulomatous. Yana taso saboda yaduwa da kuma gyara daga wasu Kwayoyin.

dalilai

Kamar yadda muka gani a sama, ainihin amsar cewa shi ne Churg-Strauss ciwo samuwa.

Masana kimiyya theorize cewa shi na iya faruwa a lokacin da wadannan yanayi:

• kwayoyin predisposition.
• bad yanayi.
• wasu cututtuka, makale a cikin wani jikin mutum.
• ƙaruwa.
• illa a lokacin da shan wasu magunguna.

A sakamakon wadannan dalilai take hakkin ya auku daidaita da kyau-aiki na rigakafi da tsarin, wanda za a fara ƙarni na autoimmune antibodies da kisa Kwayoyin wadda kai farmaki al'ada Kwayoyin kuma tsokoki a jikinsa. Da zato wannan yana sa wani karin samar da eosinophils, tun histology saukar m da mahara eosinophilic infiltrates, musamman a cikin ganuwar da numfashi tsarin.

Aukuwa na Churg-Strauss ciwo zai iya tsokana cututtuka kamar numfashi cututtuka, hepatitis, kazalika da lamba, alerji, danniya, ciki, insolation, hypothermia, haihuwa.

iri da kuma

Churg-Strauss ciwo zai iya faruwa sa samun abinci (tare da kaifi martani da kwayoyin kara kuzari a wata, tasowa 'yan kwanaki) kuma kullum (tasowa a kan watanni). Mafi sau da yawa na kullum Hakika wannan ciwo shafar numfashi tsarin da kuma bayyanar cututtuka kama asma. Yana da wannan erroneous ganewar asali da aka yi sau da yawa. A mahaɗar tsakãninsu unfavorable yanayi a kullum nau'i na cutar ne iya samar da komowan cutar. Wannan shi ne abin da ya faru a lokacin da ka soke wasu kwayoyi, misali, kullum eosinophilic ciwon huhu za a iya aggravated lokuta "Prednisone". Idan shi ne a cikin kullum nau'i na faruwa Churg-Strauss ciwo, cututtuka yawanci shafi numfashi da kuma tsarin ne kamar haka:

• tari.
• shortness na numfashi;
• nauyi asara.
• wheezing.
• shortness na numfashi.

Syndrome za a iya bayyana tare da daban-daban aiki, wanda ya kasu kashi 4 kungiyoyin:

• null.
• m.
• talakawan;
• high.

Syndrome Churg-Strauss: cututtuka, photos

A mafi daukan hankali cututtuka a cikin m nau'i na cutar dogara ne a kan abin da jiki nama shafa. Wannan na iya zama da zuciya, gastrointestinal fili, huhu, musculoskeletal tsarin, fata, da juyayi tsarin, kodan.

Saboda haka, idan zuciya, da mãsu haƙuri yana da wani arrhythmia, pericarditis (m ko sanyata), endocarditis, zuciya rashin cin nasara har zuwa wani ciwon zuciya, hauhawar jini, jini.

Idan ka m kodan, bayyanar cututtuka su ne: nephritis (mai da hankali), kuma glomerulonephritis (necrotic).

Gastrointestinal raunuka halayyar gastritis, colitis, enteritis, peritonitis, perforation na hanjinsu.

Very hali na Churg Strauss ciwo bayyana a kan fata. Photography nuna ulcerative lahani a kan ƙananan extremities na haƙuri, wanda zai iya zama rinjaye ko wasu cututtuka dangantawa da, misali, bronchopulmonary (tari, dyspnea). Sauran alamun fata raunuka ne purpura, urticaria, necrotizing miki, erythema, nodules.

numfashi cuta tare da rhinitis, asma, na huhu infiltrates.

Syndrome a cikin juyayi tsarin zai iya sa a bugun jini, polyneuropathy, encephalopathy.

A musculoskeletal tsarin ciwo bayyana amosanin gabbai, arthropathy, myopathy. Da ya faru na kowane daga cikin wadannan matsalolin na da cututtuka.

A dukkan lokuta, marasa lafiya bayar da rahoton tabarbarewar kiwon lafiya, gajiya, zazzabi, wani rauni, asarar ci, nauyi da rage.

sharudda

A shekarar 1990, da ACR aka samarwa 6 sharudda wanda ake asibiti kamu da Churg-Strauss ciwo:

1. Hašari, wheezing, bushe exhalation.
2. Eosinophils nuna alama a sama na kullum na 10%.
3. Neuropathy (na daya, ko poly), Ina nufin hanawa na aiki na jijiyoyi.
4. Pathology na hanci sinuses.
5. Infiltrates a cikin huhu, wanda za a iya migrating, m, impermanent, mai shudewa, gano a kan radiographs.
6. A nunin faifai ne kananan jini na kama jari na eosinophils a bangarori a kusa da tasoshin binciki.

Idan akwai 4 na sama sharudda, da gaban da haƙuri Churg-Strauss ciwo ne kusan bayan shakka.

dakin gwaje-gwaje ganewar asali

Mutanen da suka yi bayyanar cututtuka na sama cututtuka, da farko zuwa daidai profile na likitoci - a gastroenterologist, likitan zuciyar, likitan fata, neurologist, pulmonologist, ko ilimin Laura. Bayan jawo anamnesis, marasa lafiya za a iya sanya ƙididdiga gaskatãwa ko tunkuɗe duk Churg-Strauss ciwo. Ganewar asali dogara ne a kan:

• Jini analysis (m karuwa a ESR, eosinophils).
• kirji X-ray.
• CT huhu .
• ECG.
• microscopic jarrabawa na ruwa a cikin huhu.
• ko Bronchial biopsies na fata;
• janar fitsari bincike.
• immunoassays (wani antibody ANCA, matakin LgE).

mataki

Churg-Strauss ciwo, pathogenesis na wanda shi ne dogara a kan wurin da inflamed jini, ne zuwa kashi uku, saukarwa na kwarara:

1. Yana yana lokaci mai tsawo, shekaru da dama, da kuma a wasu lokuta a lokacin rubuta predromalnogo tsawon shekaru 10. Alamun suna gyarawa a mataki na farko, yawancin marasa lafiya:

• m rashin lafiyan halayen.
• rhinitis.
• bayyananen na fuka.
• hanci polyps bayyanar.
• sinusitis.
• doguwar, sau da yawa maimaita mashako.

2. Bright hannu na biyu mataki - karuwa da eosinophils a cikin jini, kuma xauke da cuta nama. Marasa lafiya za a iya bincikar lafiya kamar yadda eosinophilic gastroenteritis, Leffler ciwo, eosinophilic ciwon huhu, ko pleurisy. Alamun cewa bayyana a mafi yawan marasa lafiya:

• tari.
• shortness na numfashi (dyspnea).
• coughing sama da jini;
• rauni.
• myalgia.
• zazzabi.
• nauyi asara.
• tare da shan kashi na narkewa kamar fili take hakkin stool, tashin zuciya, zafi a ciki.

3. A halayyar alama na uku mataki - tsari cututtuka angiitis (vasculitis). Darajar nuna yawan eosinophils a cikin jini, zai iya tsalle har zuwa 80% da na kullum. Akwai alamun m zuciya rashin cin nasara. Kuma idan mamakin da jijiyoyin zuciya arteries, da mãsu haƙuri iya mutu. Development of Churg-Strauss ciwo a cikin CNS a cikin na uku mataki ne fraught tare da bugun jini, epilepsy seizures. Idan ta shafa gastrointestinal gabobin iya zama perforation na ciki ko hanjinsu, hanji mai shãmakacẽwa.

magani

Popular mai tsanani cuta ne Churg-Strauss ciwo. Jiyya ne da za'ayi na dogon lokaci da kuma ko da yaushe hadaddun. Primary kula likita - da rheumatologist, amma sau da yawa bukatar shawara tare da likitan zuciyar, ophthalmologist, pulmonologist da sauran kwararru. Don mayar da aikin da ya shafi tasoshin da kuma rheumatologist nada glucocorticoids cytostatics da plazmofarez da hemosorbtion. Tare da wadannan kwayoyi an wajabta anti-kumburi kwayoyi. Daga cikin fiye wajabta kwayoyi irin: "Prednisolone" (cikin kudi na har zuwa 12 watanni), "Cyclophosphamide" ko daidai (rate up to 1 shekara), "metipred" ko analogues, da antibacterial da sauran kwayoyi nuna. Ga masu rigakafin rikitarwa da marasa lafiya wajabta anticoagulants, antiplatelet jamiái, kuma vasodilators. A lokacin jiyya, da haƙuri da aka haramta shan taba da kuma ya sha barasa.

Outlook

Yana da rare, kuma mafi sau da yawa a cikin maza fiye da a mata kamu da Churg-Strauss ciwo. Yadda yawa live tare da shi, shi ya dogara da yadda sauri an fara Jiyya da kuma wanda tasoshin shafa. Statistics ce cewa ya bayyana da mafi yawa a cikin mutane girmi shekaru 40. A yara, cutar ba a gano cutar. Ba tare da lura, da hangen nesa shi ne kawai ya fi karfinsu. Tare dace da tasiri magani rayuwa fiye da shekaru 5 ne 80%. Mutuwa sau da yawa yakan faru daga jijiyoyin zuciya da kuma tasoshin cardiac aiki.