A immunoglobulin G, abin da yake da shi ga wani mutum?

Domin yaki da kamuwa da cuta a jikin mutum yayi dace da wani yawan abubuwan. Daya daga cikin mafi muhimmanci wurare a cikin wannan tsari nasa ne da immunoglobulin, ko ya zama mafi daidai, da immunoglobulin G. sauran iri immunoglobulins, IG G ya iya kare jiki daga wani jariri daga kamuwa da cuta, kamar yadda yana da ikon shiga da mahaifiyar ta jini ta cikin mahaifa, shigar da yaro ta jini.

Jigidar halittar kunshi IG G subunit, wanda nauyi ne game da 150 KD. A cikin mutane da kuma a cikin beraye, ya bayyana hudu subclasses, wanda aka immunoglobulin G. Suna farko gano by serological hanyoyin. Immunoglobulin hinjis yankin halin da manyan yawan cysteine sharan kuma a proline DNA, wadda kayyade ta sassauci. Disulfide shaidu a cikin wannan ɓangare na kwayoyin da suke sãɓã wa jũna, dangane da subclass globulin. Saboda haka, gamma 1 da kuma gamma globulins 4 da biyu disulfide shaidu, gamma 2 - hudu Gamma 3 - goma sha. A gamma 1 sarkar hinjis yankin fãra kawai daga 216-th saura kuma ƙare da 231-m. A hinjis yankin Gamma sarkar 3 located a kan arba'in da bakwai sharan daga baya fiye da 1. Gamma Nazarin ba amino acid jerin sa ya yiwu a ɗauka cewa a irin wannan karuwa a sharan hade da biyu kwafi yankunan 216-231 gamma 1 sarkar. Hinjis yankin yana da wani muhimmanci singularity: interactions ta biyu nauyi sarƙoƙi na faruwa da kuma m cyclic octapeptide Tsarin, abin da hidima a matsayin juyawa axis ga dukan m hinjis yankin, ya kuma inganta don Fab-, niƙaƙƙun gaɓãɓuwa da suke da zama dole to hulɗa tare da wani jam'i na antigens.

Halitta IG G faruwa a lokacin farko da kuma na biyu rigakafi amsa, kamar yadda irin wannan antibody ne musamman yadda ya kamata shiga cikin nama, shi ta ɗaure su da baya cire waje antigens.

Domin antibacterial kariya a jikin mutum amsa daidai immunoglobulin G. ciyar da irin wannan globulin iya zama a lokuta inda na rigakafi da tsarin ya riga ya zo a cikin lamba tare da waje antigens kuma ya fara aiki da samar da antibodies. Saboda haka, lura da karuwa a yawan lokaci immunoglobulins iya fara dace bincike da kuma magance cututtuka da sa wani iri-iri jikin kwayoyin cutar da ƙwayoyin cuta.

Babban aiki na da irin wannan immunoglobulin ne kariya daga jikin mutum daga waje jamiái iya haddasa cutar. Immunoglobulin G matsayin yaki da pathogens da kansu da kuma tare da kayayyakin da suka rayuwa ta opsonization, phagocytosis jefa tsarin da kuma yabo.

Immunoglobulin G ne thymus-dogara, cewa an hada a thymus (thymus), tare da kai tsaye hannu na T-lymphocytes. Wannan irin globulin ne babban bangaren da globulin sulusi da murabba'i na jini ne game da 80% na iri daban-daban immunoglobulins. Saboda haka, liyafar da daban-daban immunosuppressants, kazalika da daukan hotuna a cikin wani wuri ba kawai don kashe kira na IG G, amma kuma ya kashe shi gaba daya.

A immunoglobulin G, wanda shi ne na kullum a cikin jiki dabam dangane da shekaru 15 zuwa shekaru kai ta karshe matakin da shi ne 8-17 grams da lita na jini. A wannan yanayin, da immunoglobulins ne iya zama ba kawai a cikin jini da kuma kewaya a ko'ina cikin jiki, tare da jini, da suka iya kuma saukin shiga cikin extravascular sarari, tun yin duk da yawa ayyuka. Immunoglobulin G aka gaba ɗaya rarraba biyu a cikin jini da kuma sauran kyallen takarda a cikin jiki, game da shi, samar da kariya daga kwayoyin da cututtuka.