Amyloidosis - abin da yake da shi? Amyloidosis: haddasawa, cututtuka, da magani, da lifiya

Amyloidosis - abin da yake da shi? Shi ne wata cuta daga furotin metabolism a cikin abin da samuwar kuma shaida a daban-daban tsokoki da kuma gabobin da wani takamaiman furotin-polysaccharide abu - amyloid.

A ci gaba da cuta

Ci gaba amyloidosis (abin da shi ne - mun riga mun gani) a take hakkin gina jiki kira a cikin reticuloendothelial tsarin. A jini ne wani jari na mahaukaci sunadaran. Wadannan sunadarai ne da gaske kai antigens da kuma haifar da wani alerji kama da samuwar autoantibodies.

Sa'an nan kuma, wadannan antibodies da antigens da amsa grubodispersionnye sunadaran precipitate. Tun da samuwar amyloid. Wannan abu ne deposited a kan jirgin ruwa ganuwar da daban-daban gabobin. A hankali tara, amyloid take kaiwa zuwa mutuwar jiki.

Iri amyloidosis. dalilai

Akwai da dama iri amyloidosis. A Sanadin cutar ne kai tsaye dogara a kan abin da irin amyloidosis. Mene ne wannan? Nau'in ne da za'ayi bisa ga asali gina jiki, wanda ya kunshi amyloid fibrils. Kasa ne views da cutar.

1. Primary amyloidosis (AL-amyloidosis). Lokacin da ta ci gaba a jini bayyana mahaukaci immunoglobulin haske sarƙoƙi, wanda suke iya shirya a daban-daban tsokoki na jiki. Haka kuma canza a lokacin jini Kwayoyin mahara myeloma, Waldenström ta macroglobulinemia, monoclonal hypergammaglobulinemia.
2. Secondary amyloidosis (AA-amyloidosis). A wannan yanayin akwai wuce kima saki na hanta gina jiki alpha-globulin. Wannan m lokaci gina jiki da aka hada a kullum kumburi. Wannan shi ne zai yiwu a cututtuka daban-daban, kamar rheumatoid amosanin gabbai, zazzabin cizon sauro, bronchiectasis, osteomyelitis, kuturta da tarin fuka.
3. Family amyloidosis (AF-amyloidosis). Yana da wani hereditary cuta da autosomal recessive gādo. Haka kuma an kira Rum zazzabi intermittent ko paroxysmal poliserozita iyali. Bayyana wannan cuta hare-haren da zazzabi, da ya faru na ciki zafi, fata rashes, amosanin gabbai, kuma pleurisy.
4. A dialysis amyloidosis (AH-amyloidosis). Yake da alaka da gaskiya cewa furotin beta-2 microglobulin MHC a lafiya mutane an zubar da ta kodan, kuma shi ba a tace a hemodialysis, kuma haka ne ta jari a cikin jiki.
5. AE-amyloidosis. An tasowa wasu siffofin da ciwon daji, kamar thyroid.
6. Na tsufa amyloidosis.

cututtuka

Lokacin da ganewar asali "Amyloidosis" bayyanar cututtuka dogara ne a kan sarrafawa na adibas. Tare da shan kashi na gastrointestinal fili za a iya lura kara girman harshe, illa hadiya aiki, maƙarƙashiya ko zawo. Akwai iya zama ƙari-amyloid adibas a cikin hanji ko ciki.

amyloidosis na hanji tare da wani jin nauyi da kuma rashin jin daɗi iya zama m ciwon mara. Idan buga da pancreas, shi ne gabatar da wannan bayyanar cututtuka kamar yadda a pancreatitis. Idan hanta lahani kiyaye ta karuwa, tashin zuciya, belching, amai, seizures, jaundice.

Amyloidosis numfashi bayyana kamar haka:

• wanda muryarsa ta duƙushe murya.
• bayyanar cututtuka na mashako.
• na huhu da ƙari amyloidosis.

Wadannan cututtuka na iya faruwa a amyloidosis na juyayi tsarin:

• tingling ko kona abin mamaki a cikin wata gabar jiki, numbness (gefe polyneuropathy).
• ciwon kai, dizziness.
• sphincter cuta (urinary incontinence, fecal).

Amyloidosis - abin da shi ne, ta haddasawa da kuma bayyanar cututtuka mun sake nazari. Yanzu mu dubi yadda cutar da ake bincikar lafiya da kuma abin da hanyoyin da magani wanzu.

bincikowa da

A irin wannan cuta a matsayin amyloidosis, da ganewar asali ne hadaddun. Nada da dakin gwaje-gwaje da kuma hardware bincike.

A dakin gwaje-gwaje karatu, wani janar review na jini lura karuwa a ESR, leukocytes da kuma rage platelet count. A general bincike na fitsari gina jiki ne ba a cikin laka - cylinders, leukocytes da erythrocytes. A coprogram gabatar yawa sitaci, mai kuma tsoka zaruruwa. A cikin jini Biochemistry a raunuka na hanta saukar da wani karin cholesterol, bilirubin, alkaline phosphatase.

A farko amyloidosis a fitsari da kuma jini jini nuna wani babban abun ciki na amyloid. Lokacin da na biyu a lokacin dakin gwaje-gwaje gwaje-gwaje nuna alamun kullum kumburi.

Kuma gudanar da wasu bincike da matakan:

• X-ray jarrabawa.
• echocardiography (a cikin hali na wani da ake zargi da ciwon zuciya).
• aikin kima da dyes.
• biopsy jikinsu.

magani

Lokacin da cutar ne da za'ayi-haƙuri magani. Amyloidosis, a cikin abin da akwai tsanani yanayi, kamar na kullum na koda gazawar ko tsanani zuciya rashin cin nasara bi da a wani asibiti.

A farko amyloidosis farko nada kwayoyi kamar "Chloroquine" "Melphalan" "prednisolone", "Colchicine".

A sakandare amyloidosis yi wa tamkar cuta, msl, osteomyelitis, da tarin fuka, pleural empyema et al., All cututtuka na amyloidosis sau da yawa vuya bayan magani.

Idan cutar tasowa a sakamakon koda hemodialysis, sa'an nan irin wannan haƙuri da aka canjawa wuri zuwa peritoneal dialysis.

A cikin hali na zawo binders amfani da magunguna, kamar "bismuth subnitrate," ko adsorbing wakili.

Suna iya zama symptomatic magani:

• shirye-shirye rage matsa lamba;
• bitamin, diuretics.
• jini transfusions, da dai sauransu

Bugu da ƙari kuma, shi iya amfani da m magani. amyloidosis na baƙin ciki na iya ja da baya bayan da kau da sashin jiki. A mafi yawan lokuta, wannan take kaiwa zuwa wani ci gaba a cikin yanayin da marasa lafiya da kuma rage samuwar amyloid.

abinci

Amyloidosis bukatar m rage cin abinci. Tare da ci gaba na kullum koda cuta ya kamata iyakance gishiri ci, da kuma gina jiki abinci, irin su nama, kifi, qwai. Idan tasowa na kullum zuciya rashin cin nasara, ya kamata a cire daga cikin abinci da gishiri, kyafaffen kuma pickled abinci.

cardiac amyloidosis

Wannan cutar da ake kuma kira amyloid cardiomyopathy. Tare da ci gaban amyloid shaida na iya faruwa a myocarditis, pericarditis, endocarditis, ko a kan ganuwar da lakã da jijiyoyin zuciya jijiyoyi. Dalilin wannan zuciya cuta na iya zama na farko amyloidosis, secondary ko iyali. Sau da yawa amyloidosis na zuciya - shi ne ba wani ya zama ruwan dare cuta, kuma shi ne tasowa a layi daya tare da amyloidosis na huhu, koda, hanji ko baƙin ciki.

Bayyanar cututtuka na cardiac amyloidosis

Sau da yawa cututtuka da wannan cuta ne kama da hypertrophic cardiomyopathy ko jijiyoyin zuciya da cututtukan zuciya. A can farko, cututtuka su ne m. Iya samun irritability da gajiya, da wasu nauyi asara, kumburi daga kyallen takarda da juwa.

A kaifi tabarbarewar yakan auku bayan wani danniya ko numfashi kamuwa da cuta. Bayan da kullum bayyana zuciya zafi irin angina pectoris, arrhythmia, pronounced edema, dyspnea, hanta kara girma. Jini ne yawanci saukar da.

Cutar progresses hanzari, kuma da rarrabe alama ne da juriya (juriya) zuwa far. A tsanani lokuta, marasa lafiya na iya fuskanci ascites (jari na ruwa a cikin kogon ciki) ko pericardial effusion. Saboda da amyloid infiltrates ci gaba sinus bradycardia. Wannan zai iya kai wa ga kwatsam mutuwa.

Outlook

A zuciya amyloidosis matalauta hangen nesa. Congestive zuciya rashin cin nasara a wannan cuta progresses haƙuri, kuma mutuwa ne sananne. A Rasha, bãbu musamman cibiyoyin tafiyad da wannan batun.