"Azathioprine": umurci manual, reviews, bayyanai, analogs

Wanne kira ga miyagun ƙwayoyi "Azathioprine"? Umarnin a kan aikace-aikace ƙaddamar da jamiái za a iya bayyana, a wannan labarin. Mun kuma gaya maka ko akwai contraindications da analogues da wannan magani, abin da koda halin kaka, abin da zai faru idan akwai wani yawan abin sama, da sauransu. D.

Abun da ke ciki, marufi, siffar, description medicament

A abin da nau'i ne samuwa miyagun ƙwayoyi "Azathioprine"? Umarnin don amfani da shawara cewa wannan magani yana samuwa a cikin kwamfutar hannu tsari. Su aiki sashi abubuwa a matsayin azathioprine. Har ila yau a cikin miyagun ƙwayoyi da kuma hada ƙarin sinadaran a cikin nau'i na dankalin turawa, sitaci, gelatin, lactose, da alli stearate.

A wani kunshin sayar da miyagun ƙwayoyi "Azathioprine"? Umurnai na yin amfani da miyagun ƙwayoyi ne a kewaye a cikin wani kwali akwatin, wanda sanya kodadde rawaya Valium kwayoyi a bororo fakitoci na 50 guda.

Pharmacological halaye na medicament

Menene wannan magani kamar yadda "Azathioprine"? Umarnin don amfani, real gogaggen kwararru bayyana cewa da miyagun ƙwayoyi a tambaya ne wani analog "hypoxanthine", "adenine" da "Bibyun", a kunshe a cikin tsarin da nucleic acid da kuma nuna wani tarewa sakamako dangane da nama yaduwa da kuma cell division.

"Azathioprine" - immunosuppressive wakili. Its mataki ne da nufin salula cytotoxicity.

Dauke da wani magani iya hana dauki na nama incompatibility da shafi kwafi na antibodies, amma kawai don a kananan har. Idan aka kwatanta da "mercaptopurine" aiki miyagun ƙwayoyi farfado da mafi pronounced.

Pharmacokinetic miyagun ƙwayoyi

Bayan baka magani ne da tunawa daga cikin gastrointestinal fili. Yana yana da wani low bond tare da jini sunadaran (kimanin 30%).

A biotransformation da miyagun ƙwayoyi saki ya auku tare da tioinozinovoy acid da kuma mercaptopurine (Ina nufin, aiki metabolite). A kananan adadin magani a cikin nama. A wannan yanayin, a kananan taro na miyagun ƙwayoyi samu a cikin kwakwalwa.

A rabin-rai na azathioprine, kuma ta aiki metabolites ne game da 6 hours. Cincirindo miyagun ƙwayoyi a cikin jini ya lura bayan 70-110 minti.

Da miyagun ƙwayoyi ne kusan gaba daya dakatar tare da bile, kuma kawai 1-2% - by kodan.

alamomi Allunan

Abin da prescribers "Azathioprine" (umarnin don yin amfani da kwayoyi, analogs, reviews za a gabatar daga baya)? Wannan shiri bayyana kanta yadda ya kamata a lokacin da wadannan munanan:

• psoriasis.
• rheumatoid amosanin gabbai.
• ja tsari lupus erythematosus .
• ulcerative colitis.
• dermatomyositis.
• myasthenia gravis.
• Pemphigus maras ɗa'a.
• periarteritis nodosa.
• Crohn ta cuta .
• glomerulonephritis, autoimmune.
• kullum aiki hepatitis.
• Reiter ta ciwo .
• purpura idiopathic thrombocytopenic.

Ya kamata kuma a lura cewa wannan magani ne sau da yawa wajabta rigakafin dashi kin amincewa. Amma a cikin wannan hali shi ne riƙi a hade tare da sauran magunguna.

Contraindications ga yin amfani da kwayoyi

Umurnai na yin amfani da miyagun ƙwayoyi "Azathioprine" ta sanar da marasa lafiya game da wadannan contraindications:

• hanta gazawar ;
• hypersensitivity zuwa aiki ko karin aka gyara magani.
• a lokacin daukar ciki.
• da yanayin raunana hematopoiesis.
• yara shekaru.
• nono.

Medicament "Azathioprine": Sashi da kuma gwamnati

Kai "azathioprine" Allunan kamata kawai a gudanar da baki. A kowane hali dai, kashi na da miyagun ƙwayoyi ne m akayi daban-daban, dangane da samuwa shaida, kazalika da tsananin cutar da kuma concomitant far.

Ga masu rigakafin dasa kin amincewa da magani wajabta a hade tare da "cyclosporin" da kuma corticosteroids. A farkon shan magani far a wani loading kashi cewa shi ne 5 MG da kg (a kan watanni biyu). Daga bisani dauki magani a gyara kashi (1-4 MG da kg a 3 allurai). Yawanci, irin wannan magani yana ci gaba na dogon lokaci. Idan ka soke far kashi na magani ake saukar da hankali.

A abin da ya faru na farko alamun kin amincewa da transplanted Gabar ake bukata domin kara da kullum sashi na medicament sake zuwa 4 MG da kg.

Domin lura da wasu cututtuka medicament kullum gudanar a wani kullum kashi na 1.5-2 MG da kg zuwa 4 raba allurai. Idan ya cancanta, da kayyade adadin da miyagun ƙwayoyi za a iya ƙara zuwa 200-250 MG (kasu kashi 4 allurai). A tsawon lokaci da magani tare da wannan kayan aiki da ake kafa akayi daban-daban, wani gogaggen gwani.

Yadda za a yi amfani da "Azathioprine" (Allunan) a rheumatoid amosanin gabbai? Umarnin don amfani, ratings (aka bayyana a shirye-shiryen da aka gabatar a sama) ya furta cewa, domin lura da irin cututtuka wajabta 1-2.5 MG da kg per day (kasu kashi 2 allurai). Duration na far ya kamata a kalla watanni 3. Kamar yadda goyon bayan da haƙuri da aka ba a kashi na 0.5 MG da kg (guda kashi).

Domin lura da kullum hepatitis B (aiki) rubũta a kullum kashi na 1-1.5 MG da kg.

Lokuta da miyagun ƙwayoyi yawan abin sama

Mene ne bayyanar cututtuka na yawan abin sama faruwa a daidai liyafar "Azathioprine" miyagun ƙwayoyi? Umarnin don amfani, real Likitoci bayyana cewa mafi girma kashi na miyagun ƙwayoyi iya sa daban-daban dyspeptic jihar, pancytopenia, cuta na hanta ayyuka da kuma inganta sauran gefen sakamakon da miyagun ƙwayoyi.

Kamar yadda magani daga irin mamaki amfani symptomatic far. Idan dole, hemodialysis. Duk da haka, ka sani cewa wannan hanya ba ta ba da tabbacin cikakken kawar da aiki abu daga jiki.

miyagun ƙwayoyi interactions

Kamar sauran kwayoyi rinjayar miyagun ƙwayoyi "Azathioprine"? Umurnai na amfani jihohin da Co-gwamnati na da wakili da "Allopurinol" iya bunkasa mai guba effects na farko, da kuma a tare da tare da "co-trimoxazole" sau da yawa take kaiwa zuwa ƙãra myelotoxic effects.

Lokaci daya da magani tare da ACE hanawa kara hadarin mai tsanani leukopenia.

A hade tare da sauran immunosuppressants (msl, "Cyclosporins", glucocorticoids, anti-CD3 antibodies) sau da yawa sosai da dama neoplasms da kuma cututtuka.

An fito da shirye-shiryen farfado antagonistic sakamako ga nedepolyarizuyushim tsoka relaxants.

Ya kamata kuma a lura da cewa lamba a lokacin jiyya "azathioprine" iya quite iya kai ga danniya na samar da antibodies (a cikin hali na inactivated alluran), kazalika da kara kwayar kwafi (tare da gabatarwar live alluran).

takamaiman shawarwari

Abubuwa sani kafin ka rubũta magani "Azathioprine"? Umarnin don amfani, real (analogues magunguna da aka jera a kasa) jiha cewa a lokacin farkon watanni biyu na far ake bukata a kowane mako don tsayar da juna na gefe jini. Bayan wannan lokaci, nazarin ya nuna da aka gyara tare da wani mita na 1 kowane kwana 30.

Shi ne kuma dole ka saka idanu da matakin na bilirubin, alkaline phosphatase da hanta enzymes.

A gaban munanan na koda ko hanta, kazalika da hadin gwiwa liyafar tare da "Allopurinol" medicament sashi a karkashin shawara dole ne a rage zuwa 1/4 ɓangare.

"Azathioprine" tare da matsananci hankali sanya wa marasa lafiyar a wanda bãbu herpes zoster, karambau, xanthine oxidase rashi, da kuma a lokacin radiation ko cytotoxic far.

Analogues da miyagun ƙwayoyi farashin

Abin da zai iya maye gurbin "Azathioprine"? Umurnai na amfani (da farashin da magunguna da aka jera a kasa) jihohin da suka dauke da miyagun ƙwayoyi yana da 'yan takwarorina. A mafi kama a bugu sun hada da wadannan magunguna:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Amma ga farashin, to, wannan samfurin ba sosai high. 50 Allunan "azathioprine" a kan talakawan ne game da 230 Rasha rubles.

Reviews na medicament

A 'yan reviews da miyagun ƙwayoyi "Azathioprine" na nufin gauraye. Wasu mutanen da shan magani saboda wani autoimmune cuta, gamsu da ta tasiri da daukan hotuna da kuma rashin tsanani illa. Others, duk da haka, marasa lafiya ba ji da wani sakamakon, sabili da haka suka yanke shawarar ba su son zuwa wasu wajen.

Ya kamata a lura cewa duk da alamomi na yin amfani da miyagun ƙwayoyi "Azathioprine" koma zuwa wani wajen tsanani cututtuka ga wanda isasshen far iya zama wani gogaggen sana'a. A wannan batun, a cikin hali na tuhuma a gaban wani cuta daga sama list, dole ne ka sha wani m likita jarrabawa, ba don kai-medicate.