Alkaline phosphatase - wani muhimmin enzyme jikin mutum

Don kwanan wata, da hadaddun ganewar asali da yawa cututtuka amfani da dakin gwaje-gwaje da hanyoyin da jarrabawa. Wannan ya shafi wani biochemical bincike na jini.

Alkaline phosphatase: general halaye na enzyme

Alkaline phosphatase - daya daga cikin mafi muhimmanci Manuniya. Wannan fili shi ne wani enzyme wanda farfado phosphatase aiki. Shi ne yanzu a kusan duk mutum Kwayoyin. Its iyakar aiki ne da aka nuna a cikin wani alkaline matsakaici da kuma ake dangantawa da cell membranes. Cincirindo wannan fili, yana rubuce a osteoblasts (Kwayoyin a kashi nama), hanta Kwayoyin kuma koda tubules a cikin hanji mucosa, kazalika da Mahaifa. Alkaline phosphatase, wanda aka dauke a cikin magani, kamar yadda mai mulkin, samu daga kashi ko hepatocytes. Its high aiki da aka gani da farko a cikin hanta cututtuka da cewa faruwa tare da toshewa da bile bututu, kazalika a raunuka daga kashi suna tare da kashi maimaita.

Alkaline phosphatase matakin ne high. Me ya sa?

Akwai da yawa cuta jihohi a wadda ta ƙara alkaline phosphatase. A kullum na wannan nuna alama dogara da shekaru da kuma jima'i, don haka ya dauki wannan a cikin asusun a lokacin tafsirin jini Biochemistry.

Daga cikin etiological abubuwan da zai iya rinjayen matakin na enzymes, ciki har da alkaline phosphatase, ya kamata sun hada da wadannan:

• ciki.

• Postmenopausal.

• kasa ci na abin da ake ci alli, da kuma phosphates.

• wuce haddi na ascorbic acid a cikin jiki.

• yin amfani da guda pharmacological jamiái (msl, hana dauke da estrogen da progesterone, kazalika da maganin rigakafi).

Bugu da kari, alkaline phosphatase iya ƙara a cikin wadannan cututtuka:

• hyperparathyroidism.

• ciwon zuciya da koda ko huhu nama.

• mahara myeloma.

• dauke da kwayar cutar mononucleosis.

• kashi cuta, ciki har da ciwon daji na halitta.

• Hodgkin ta cuta, wanda ya auku tare da lalata kashi.

• rickets.

• m rauni na biliary fili.

• kumburi da cututtuka yanayi ko cirrhosis na hanta, ta sha kashi da tarin fuka.

Etiology rage alkaline phosphatase

Akwai da dama daga pathologies a cikinsa, a akasin haka, alkaline phosphatase rage. Saboda haka, matakin da enzyme kasa al'ada a hypothyroidism. Take hakkin ci gaban kashi, rashi na tutiya da magnesium, kazalika da anemia - etiological abubuwan da zai iya rinjayen adadin alkaline phosphatase a cikin jini magani. Shan wasu magunguna kuma canza gwajin sakamakon. Bugu da ƙari, kasancewar scurvy, wanda tasowa saboda da insufficiency na ascorbic acid take kaiwa zuwa wani karu da enzyme.

Ya kamata a lura da cewa a ciki alkaline phosphatase iya girma da kara yawan placental isoenzyme. Wannan shi ne hali na karshe matakai na ciki da kuma ake dangantawa da matsakaicin ci gaban da Mahaifa. Irin wannan fasalin yana da wani bincike darajar, don haka shi ne, ba m for kimantawa da jihar na uwa ko tayi. A lokuta a lõkacin da wata mace da aka yi fama placental insufficiency, da maida hankali na wannan fili ne rage enzyme.

Features na canji da matakin na alkaline phosphatase

Alkaline phosphatase ne a cikin nau'i na dama isoenzymes. A mataki na karuwa a taro na fili da aka dangantaka da aiki osteoblastic (kashi samuwar tsari), don haka cewa matakin qarshe na kashi isoenzyme lura a Paget ta cutar. Idan haƙuri tasowa da Pathology da osteolytic aiki (misali, mahara myeloma), da alkaline phosphatase karuwa, amma kawai dan kadan.

Lokacin da raunuka na hepatobiliary tsarin qara hanta isoenzyme. A asibiti yi, shi da ake amfani da matsayin alama daga cholestasis. A wannan yanayin, da kai tsaye asarar hanta Kwayoyin zai iya faru a kan bango na al'ada ko low matakan da alkaline phosphatase. Wannan juna ne hankula, kamar yadda mai mulkin, domin mafi asibiti lokuta, ko da yake yana iya ba za a lura a mutum haƙuri, har ma da lalacewar da hanta ko biliary fili.

Shi ne ya kamata a lura da cewa ƙãra alkaline phosphatase a wani yaro - a physiological sabon abu, wanda ake dangantawa da karfi girma. Saboda haka, matakin da wannan enzyme a yara na iya isa wani matakin da ya wuce na kullum ga ya fara tasawa mutum ne 1.5-2 sau (daga 82 zuwa 341 U / L).

Bayani dalla-dalla kayyade matakin na alkaline phosphatase

A ranar, da mafi kyau duka yanayi na bincike a kan tabbatar da dalilin da taro na alkaline phosphatase ne daban-daban, domin kowane dakin gwaje-gwaje na da nagartacce. Akwai da dama kima hanyoyin wanda ya dogara a kan enzyme substrate da buffer tsarin kazalika da yawan zafin jiki a da samfurori da ake gudanar. Uniform iyakoki nuna alama "alkaline phosphatase" ba, don haka ba lallai ba ne kwatanta dabi'u na enzyme, wanda aka samu a cikin daban-daban dakunan gwaje-gwaje. Wannan Gaskiya ne, a lokacin da shi ba a san abin da yake mallakar wadannan dakunan gwaje-gwaje kafa.

Domin bincike na jini magani da ake amfani. A mafi yawan lokuta, shan saman Layer, wanda aka kafa a cikin SEPARATOR tube. Shi ne ya kamata a lura da cewa matakin na alkaline phosphatase iya karyata ƙãra, idan jini Samfur tourniquet a kan babba reshe an hõre ga fiye da 30 seconds. Bugu da kari, da aiki da wannan enzyme iya bambanta dan kadan idan jini samfurin da aka adana a dakin da zazzabi. A wannan a vitro hemolysis ba zai tasiri a gwajin sakamakon.

Abin da ya yi a lokacin da wani pathological matakin na alkaline phosphatase?

Lokacin da alkaline phosphatase ya karu, da magani dole ne etiological shugabanci. Kamar wancan ne, gaban hanta ko biliary cututtuka kamata shawarta a gastroenterologist. Cholestasis, gaban pancreatitis, giya hepatitis ko cirrhosis bukatar daidai gyara miyagun ƙwayoyi wanda ƙarfi ne kawai ƙaddara da likita. Kai a cikin wannan yanayin zai iya haifar da wani ƙarin tsanani na farko cuta.

Canza taro na enzymes, ciki har da alkaline phosphatase, za a iya lura a zuciya rashin cin nasara, da ciwon daji Pathology, kuma mai tsanani lalacewar kodan, kazalika a ciwon sukari, don haka ya kamata ka yi shãwara a likitan zuciyar, nephrologist ko endocrinologist. Likita zai ƙayyade warkewa dabara dangane da asibiti hoto.

A cire etiological dalilai, alkaline phosphatase aiki ya kõmo zuwa al'ada. A nada far ya kamata a dauka la'akari da cewa, misali, wata physiological karuwa da wannan nuna alama ne yiwu tare da samu karaya, aiki girma daga cikin kwarangwal tsarin, tare da gestation. Yana ba ya bukatar likita shiga tsakani. Fassarar da sakamakon awon gwaje-gwaje kamata a da za'ayi a fahimce, shan la'akari da wasu biochemical sigogi da haƙuri gunaguni.