Bisphosphonates (kwayoyi): description, umarnin, reviews. Bisphosphonates da magani daga osteoporosis

Lokacin da ƙasusuwan mutane zama m da kuma gaggautsa, da kuma yadda ya faru a wasu cututtuka na kashi, da ingancin rayuwa da aka rage muhimmanci. M samu karaya, zafi a cikin gidajen abinci, kashin baya da kuma wata gabar jiki fara zuwa bi mutumin a ko'ina, wanda shi ne dalilin da ya sa za ka iya gaba daya dakatar ji da farin ciki na rayuwar da kũtsa a cikin fid da zuciya.

Amma mu farin ciki ne tare da ku a duniya a yau ne na musamman da kwayoyi da cewa za a iya yadda ya kamata karfafa kashi nama. Shi ne game da su, kuma za a tattauna a cikin labarin. Kira wadannan kwayoyi "bisphosphonates" - kwayoyi da sake bitar wanda zai iya bayar da begen wata warkewa ga mutane da yawa matsananciyar mutane. Yi imani da ni, irin wannan mai yawa! Za mu gaya muku game da tarihin wadannan kudi, game da abin da suka kasance haka mai kyau, abin da shi ne tushen da kiwon lafiya amfanin, zai buga sunayen da bisphosphonates ne mafi mashahuri da kuma tasiri.

A labarin da zai zama da amfani ga kowa da kowa. Bayan duk, ko da idan a yau duk abin da yake a cikin tsari, sa'an nan, da rashin alheri, shi ba ya nufin kiwon lafiya da ku, kuma ku masõyansa, shi zai šauki har abada. Shekaru, tare da Bugu da kari da cuta ne mafi zama da more. Saboda haka abin da game zamani magunguna ba zai zama superfluous. Amma isasshen na masu zuwa! Bari mu matsa zuwa wani karin tsanani nazarin jigo na wannan labarin.

Bisphosphonates - kwayoyi for kashi kiwon lafiya

Zababben kungiyar na roba kwayoyi da cewa suna da ikon toshe jiki ta aiki na osteoclasts (Kwayoyin cewa halakar da kashi nama) da kuma mayar da kashi tsarin da aka sani a matsayin bisphosphonates.

Amfani da wadannan kwayoyi ne a halin yanzu a farko wuri domin kula da marasa lafiya da osteoporosis da kuma sauran cututtuka da suka haddasa gaggautsa kasusuwa. A mafi muhimmanci da dukiya na bisphosphonates ne ma cewa su iya amfani da oncological cututtuka halin da samuwar marurai a kashi. A cikin wadannan lokuta, da miyagun ƙwayoyi, wanda ya gaya mana labarin, ba ba metastases yada da kuma rage zafi a cikin wadannan marasa lafiya.

Ginshikai na mataki na bisphosphonates da magani daga osteoporosis

A babi na baya, ka koya cewa bisphosphonates - kwayoyi da inganta koshin lafiya ƙasũsuwa. Yana da lokacin magana game da ginshikai na su mataki. Our jiki ta Kwayoyin suna da wani gagarumin ikon daga lokaci zuwa lokaci za a sabunta kuma gyara. Kashi nama - shi ne ba togiya. Daidaita Tsarin sun kiyaye, a hannu daya, da osteoblast Kwayoyin da suke da alhakin gina sabon nama, da sauran - osteoclasts da suke da alhakin ta hallaka. BF da ikon rage gudu aikin osteoclasts kuma ko da gudu su kai-destruct inji. A wannan gagarumar dukiya da kuma tushen bisphosphonate magani daga osteoporosis.

Dole ne in ce cewa ya zuwa yanzu masana kimiyya sun ba da cikakken gane da tarewa inji na kashi hasãra amfani bisphosphonates. An sani cewa wadannan abubuwa suna iya su ɗaure zuwa hydroxyapatite kashi sassan, inda suka iya canza ta lankwasawa da kuma a lokaci guda rage jini taro na hydroxyproline da phosphatases.

Wani lokaci BF shirye-shirye iya gudanar a lura ko da cututtuka kamar herniation ko protrusion na intervertebral fayafai, kamar yadda analgesic jamiái. Kuma kadan ƙarin bayani: bisphosphonates for osteoporosis aka yi amfani da na dogon lokaci, amma ga ciwon daji, suka yi an yi amfani da kwanan nan. Ta hanyar nazarin an gano cewa, shigar da jiki, inda da aiki samuwa a cikin neoplastic tsari, bisphosphonates ba su bayar da ƙari Kwayoyin coalesce da kashi matrix da kuma game da shi hana samuwar metastases. More cikakken bayani game da wannan za a tattauna a raba babi.

A kadan tarihi

Sai dai itace cewa bisphosphonates aka gano da masana kimiyya na dogon lokaci, ko da a cikin XIX karni. Domin da farko lokacin da kira na farko BF aka za'ayi a Jamus. Yana mamaki cewa wadannan abubuwa asali amfani kawai a wurare daban daban da masana'antu sassa (domin samar da takin, da yi na yadudduka, man fetur refining da kuma kama. D.) Kuma da alaqa da magani da ba.

Domin likita dalilai - domin lura da kashi - bisphosphonates fara da za a yi amfani da kawai a cikin tsakiyar karni na ashirin, lokacin da aka gano su da ban mamaki dukiya tasiri tafiyar matakai kamar calcification da decalcification. Bisphosphonates for osteoporosis amfani tun a duniya su ne sosai aiki.

rarrabuwa na bisphosphonates

Yau, pharmacology ɓullo da tsara ta uku biosfosfonatov. Amma wannan ba ya nufin cewa likitoci sun gaba daya watsi da amfani da kwayoyi na farko da na biyu tsara, wanda aka ƙãga yawa a baya. Far daga shi! Yau akwai mutane da yawa da kwayoyi da cewa su ne bisa bisphosphonates. Duk wannan iri-iri na magunguna ne zuwa kashi biyu kungiyoyin: bezazotovye magunguna da kuma nitrogen. Su sakamako a kan osteoclast Kwayoyin yana da wani daban-daban inji. Kasa za mu dubi biyu kungiyoyin a more daki-daki.

Nitrogen-dauke da bisphosphonates

Wannan kungiyar da kwayoyi ne bisphosphonates, dauke da wadannan aiki sinadaran:

• Ibandronatovaya acid. E abu da aka hada kwanan nan, don haka ne miyagun ƙwayoyi tsara ta uku. Ana amfani da mafi nasarar da magani da kuma rigakafin osteoporosis a matan da suka yi fama da tsawon menopause. Maza da shan wannan magani ba da shawarar. Ibandronatovuyu acid da aka yi amfani da ma a pathological karuwa a cikin jini alli (hypercalcemia).
• Zolendronovaya acid. Har ila yau, da dangantaka da wata uku tsara bisphosphonate. Iya aiki selectively a kan kashi nama. Tare da wannan da aka yadda ya kamata amfani domin lura da osteoporosis. The zabe mataki zolendronovoy acid a kan kashi tsarin dogara ne a kan ta high dangantaka zuwa osseous raga cewa samar da kyau kwarai hanawa na osteoclasts. Wani muhimmin dukiya daga cikin miyagun ƙwayoyi - a pronounced anti-ƙari sakamako. A kan tushen da samuwa acid zolendronovoy m bisphosphonates "Zometa", "Zolendronat".
• Alendronate sodium - wani biyu ƙarni wajen bisphosphonates. Yana da wani maras hormonal takamaiman mataimaki rayuwa kashi nama kafa da daidai tsarin da kashi. An nuna don amfani a osteoporosis mata da maza.
• Ibandronate sodium ( "Bonviva" "Bondronat" "Boniva" - bisphosphonates shirye-shirye a kan ta da asali) - tsara ta uku kwayoyi. Damuarn osteoclast aiki ba tare da yawan su. Yana ba adversely shafi samuwar kashi Kwayoyin, haka yadda ya kamata a rage ga halaka su. Good taimako a postmenopausal mata a matsayin m wakili daga kashi samu karaya.

Shirye-shirye cewa ba dauke da nitrogen

Kuma yanzu za mu mayar da hankali a kan abin da suke a nitrogen-free bisphosphonates. Kwayoyi, wanda sunayen ka karanta yanzu, ya kasance a cikin ƙarni na farko na bisphosphonates:

• "Clodronate." Yana hana biyu osteolysis da hypercalcemia ci gaba. Yana Forms wani hadadden dangane da hydroxyapatite kashi musanya crystal raga da kuma rayayye counteracts rabuwa na alli da phosphate kwayoyin. Metastases a cikin kasusuwa hana a ci gaba da kuma tubalan halittar sabon abokai.
• "Sodium Etidronate". Inganta harkokin maido da kashi hasãra a mata da ganewar asali "osteoporosis". Yana kuma iya a yi amfani da Paget ta cuta, hypercalcemia da kuma kama. D.
• "Sodium tiludronate". Mineralizes da kuma karfafa kashi nama, tara a cikinta kwayoyin fili da alli phosphate, damuarn halakar kashi. Kuma an wajabta, ga marasa lafiya da diagnoses na "deforming osteodystrophy" ko "Paget ta cuta" iya nada maimakon ji ba gani.

Bisphosphonates - kwayoyi, da jerin wanda muka buga - sayar kawai a kan takardar sayen magani, cewa shi ne ya zama m abubuwa ... Amfani da su a da hankali zai iya zama haɗari ga lafiyarka. Ka tuna cewa BF - ba m bitamin ko kari da alli. Wadannan kwayoyi suna rayayye shiga tsakani a cikin matakai abin da ke faruwa a cikin jiki, da kuma idan improperly amfani iya taimaka maimakon cuta.

m dokoki

bisphosphonates kwayoyi quite nauyi tunawa da gastrointestinal fili, su sha wuya. Saboda haka, yana da karfi umurci umurci shan wadannan kwayoyi ne kawai a kan komai a ciki, game da minti 30 kafin a ci abinci - shi yawanci yakan taimaka wa sha na aiki miyagun ƙwayoyi abubuwa. Marasa lafiya bukatar su sani cewa wannan kungiya da kwayoyi iya haddasa kumburi da kuma yashewa a sassa daban daban na gastrointestinal fili. Don kauce wa irin wannan rikitarwa, bayan samun Allunan zama dole a gwada a lokacin sa'o'i ka tafi ba, ya kuma zauna a mike matsayi. A sashi da aka zaba ta hanyar halartar likita.

Yawanci, da nada bisphosphonates likita zayyana haƙuri har yanzu da ingestion na manyan allurai na alli. Saboda haka, lokaci daya liyafar na biyu cire. Shirye-shirye dauke da alli, za a iya dauka bayan shan bisphosphonate kawai bayan sa'o'i biyu, da kuma ba da. Wani muhimmin shawarwarin: CF da sha ba shayi, madara, ruwan 'ya'yan itace, ko kofi, da kuma a fili ruwa (mai yawa).

A amfani da bisphosphonates a neoplastic cututtuka

More magana game da bisphosphonate magani daga cututtuka shafe ci gaban da marurai na daban-daban yanayi. Da ya faru na metastasis a kashi nama ne gefe da gefe da na juna hulda tsakanin ƙari Kwayoyin da kuma rayuwa aiki na kashi nama. Bi da bi, da tsauri ci gaban metastases yana tare da mannewa na ƙari Kwayoyin zuwa kashi Tsarin, kazalika da mamayewa, da kuma yaduwa neoangiogenesis. Wurare da dama a preclinical karatu sun yarda da masana kimiyya yi zato cewa BF hana kowane daga cikin wadannan matakai na pathogenesis.

A cikin shakka daga dama bincike shirye-shirye mu kimanta sakamakon bisphosphonate "Clodronate" a kan ci gaban metastases a kashi a mata kamu da cutar sankarar nono. kyau kwarai sakamakon da aka samu: shirye-shiryen taimaka wajen rage abin da ya faru na metastases da kuma ci gaban da sabon kashi nama a marasa lafiya. A halin yanzu, bincike a cikin wannan shugabanci ake ci gaba da rayayye. Bisphosphonates lokacin da kashi metastases ne da gaske iya taimaka.

M marurai suna sau da yawa tare da hypercalcemia (alli saki daga kashi). Lokacin da metastatic rauni daga kashi alli m asarar faruwa saboda ta hallaka ta osteoclasts. Bugu da kari, hypercalcemia a ciwon daji m faruwa saboda daukan hotuna zuwa wani ƙari peptide. Bugu da ari, akwai kunnawa da osteoclasts, abu don hypercalcemia. Wannan tsari ne mai rikitarwa, kuma ma kara da rage koda aiki.

Wadannan matakai kada faruwa da irin wannan malignancies kamar yadda squamous cell sankara, mahara myeloma, nono, da na koda cell ciwon daji da kuma wasu lymphomas. Hypercalcemia, tsokane ta da ciwon daji, mafi inganci da kwayoyi ne bisphosphonates ga igiyar jini jiko. To kafa a wadannan lokuta, irin kwayoyi, bisphosphonates, kamar yadda "Zolendronovaya acid" da "Pamidronate".

Abun Lura nuna cewa tuni 'yan kwanaki bayan qaddamarwa na gwamnati ga marasa lafiya intravenously data kwayoyi a cikin jini alli taro ne bisa al'ada, da kuma sakamako yana for quite dogon lokaci na lokaci (daga daya zuwa makonni biyu).

A jerin cututtuka a wadda bisphosphonates ana amfani da nasara

• Osteoporosis.
• Myeloma.
• Take hakki na kashi samuwar.
• Paget ta cuta (osteodystrophy deforming).
• Primary hyperparathyroidism.
• Marurai metastases a cikin kashi, musamman a hade tare da hypercalcemia.

illa

Abin baƙin ciki, da aiki bisphosphonate magani ba zai iya zama innocuous. Musamman lõkacin da ta je igiyar jini gwamnati na wadannan kwayoyi. Sun iya sa da wadannan korau illa:

• Lokacin gudanar intravenously, - hypocalcemia.
• Iya adversely shafi kodan, sa maye.
• Wani lokacin liyafar Amine biosfosfonatov tsokani ci gaban osteonecrosis na muƙamuƙi.
• Taimakawa wajen raya ulcers a cikin esophagus kuma a cikin ciki.
• Zai iya sa maƙarƙashiya ko zawo, a rare lokuta - wahala a hadiya.
• Janar malaise, wani rauni, tashin zuciya.
• Muscle zafi.
• Vision matsaloli.
• Rashes a jiki.

Na'am, duk wadannan matsaloli iya sa bisphosphonates. Kwayoyi, sunayen wanda ka hadu a cikin wannan labarin, ba za ka iya sanya kaina da kansa ya ba da gangan sa jiki irreparable cutar. Mun gangan maimaita shi sau da yawa a cikin rubutu. Kuna hukunta da sake dubawa, wanda za a iya karanta a cikin daban-daban forums, mutane suna rayayye raba bayanai tare da juna game da daban-daban BF kuma readily bayar da shawarar da su zuwa wasu. Wannan shi ne da ɗan unethical. Ka ɗauki waɗannan m kwayoyi wajibi ne kawai a kan shawarwarin da halartar likita da kuma ko da yaushe a karkashin dubawa.

Bisphosphonates - reviews na likitoci da marasa lafiya

Shin, ba ka san cewa a kowace shekara, a kan Oktoba 20, a duk ƙasashe na World Day of yaki da osteoporosis? Wannan cuta a cikin 'yan shekarun nan, nemowa mai gaske annoba rabbai. Ko da yake wasu masana sun yi imanin cewa gaggawa na matsalar osteoporosis ne da ɗan karin gishiri, saboda da cutar ba a kanta m. Duk da haka, da yawan tsofaffi mutanen da suka mutu bayan da wani hip karaya, wanda yakan faru ne idan aka kara kashi hasãra ne manya-manyan. Saboda haka, mai girma yawan mutane yana da musamman fatan a kan bisphosphonates. Sharhi kan marasa lafiya da suke samu wadannan kwayoyi saboda bege na dawo, imbued tare da godiya ga likitocin da kuma na zamani pharmacology, wanda ya iya samar da su da dace taimako.

Dr. med. , Farfesa kuma shugaban na Scientific-Clinical Center of osteoporosis Svetlana Rodionova yi imanin cewa, halin da ake ciki tare da osteoporosis tsanani isa a Rasha. A sanannen likita ya ce a cikin mu kwana, a lokacin da ikon da mafi yawan mutane ne m (rashin alli), samun taro rarraba wannan miyagun halaye kamar shan taba, da yin amfani da kwayoyi da barasa, da kuma jiki aiki ne hanzari gabatowa sifili, da yawa matasa, yafi mata suna wanzuwa ga mafi balagagge shekaru osteoporosis. Saboda haka da bukatar kyau inganci da kwayoyi ya taimake warkar da wannan cuta ne sosai high.

Amma ga m likita ta nada bisphosphonates, da farfesa na ra'ayin cewa shi ba a ko da yaushe barata. Bisphosphonates - yi-bunkasa kwayoyi, amma haƙuri kafin danganci wani musamman sayen magani, likita dole ne a tabbatar an yi la'akari da irin abubuwan da metabolism daga kashi da alli homeostasis. Lokacin da m kuma uncontrolled bisphosphonate far iya haifar da tsanani da rikitarwa: atrial fibrillation, osteonecrosis na muƙamuƙi, subtrochanteric samu karaya na femur.

Bisa ga ra'ayin da ake girmamawa likita, bisphosphonates ba a duniya da dama,, su yi amfani da ya kamata a kusata tare da taka tsantsan. A halin yanzu, shirin "Lafiya" da aka watsa shirye-shirye a talabijin, inda Elena Malysheva tare da wani dadi murmushi tabbatar da masu sauraro cewa babu wani abu sauki fiye da za a bi domin osteoporosis, wani na uku-ƙarni bisphosphonate. Kada samun ma dogara infomercial. Wasu mutane samun BF ne cikakken contraindicated. Alal misali, marasa lafiya da tsanani na koda cututtuka.

Yanzu ga wani nazari a kan yadda za a yi aiki bisphosphonates lokacin da kashi metastases. Medical ra'ayi ne bayyananne: wadannan kwayoyi ne da gaske iya dakatar da ci gaban kashi na m Kwayoyin, wanda, ba shakka, na taimaka marasa lafiya shawo kan daya daga cikin mafi tsanani cututtuka, wanda kawai wanzu a duniya.

ƙarshe

Yanzu ka san abin da shi ne - bisphosphonates. Umurnai na su yi amfani da saita fita a nan, kazalika da jerin kwayoyi da aka ba mu ba kamar yadda wani shawarwarin da su ga shiriya kawai - don Allah biya ka kulawa ta musamman ga wannan! Idan tsanani matsaloli ba bukatar kai-medicate da kiwon lafiya, da mafi kyau - da sauri ganin likita, don haka ya dauki ka ka likita shirye-shirye. Muna so ku duka robust kiwon lafiya da farin ciki!