MMF (mycophenolate mofetil): description, analogs

Mycophenolate mofetil (INN Mycophenolic acid) yana kunshe a cikin rukuni na immunosuppressants. Bari mu bincika a cikin mafi daki-daki, a lokuta da shi wajibi ne don amfani da miyagun ƙwayoyi, abin da su ne contraindications zuwa ga yin amfani da illa.

Bugu da kari, za mu gano idan akwai a zamani pharmacology kama hanya.

Takaitacciyar

mycophenolate mofetil samuwa ne a cikin nau'i na tukuru gelatin capsules a hauren giwa da fararen foda ciki.

Saya kwayoyi a Pharmacy kawai idan kana da takardar sayen magani daga likita.

Shiryayye rayuwa ne shekaru biyu da nufin. Ci gaba da ya kamata ya kasance a zazzabi har zuwa 25 digiri.

Domin da na gani fahimtar yadda muka duba yiwuwar kamannuna miyagun ƙwayoyi (mycophenolate mofetil), photo sama bauta wa da misali misali.

da miyagun ƙwayoyi

Daya kwantena nufin ya ƙunshi 250 MG na aiki fili (mycophenolate mofetil). Bugu da kari, yanzu da kuma karin aka gyara, kamar croscarmellose sodium, microcrystalline cellulose, povidone da magnesium stearate.

Pharmacokinetics

Bayan da miyagun ƙwayoyi ne ta da cikakken sha da kuma cikakken presystemic metabolism. A wannan yanayin, da maida hankali na aiki abu a cikin jini yana lura saboda ta m canji a cikin aiki metabolites.

Yana nufin excreted tare da fitsari da kuma tumbi.

alamomi

A wasu lokuta, yi amfani da mycophenolate mofetil? Umarnin don amfani da sauri amsa wannan tambaya.

Doctors rubũta shan miyagun ƙwayoyi domin prophylaxis na m dashi kin amincewa a marasa lafiya bayan koda dasawa, hanta ko zuciya.

contraindications

Akwai mutane da yawa ba lokuta inda yin amfani da miyagun ƙwayoyi ne tsananin haramta "Mycophenolate mofetil". Wadannan sun hada da gaban haƙuri ta hypersensitivity da babban aiki abu ko wasu aka gyara na da wakili, kazalika a lokacin daukar ciki da kuma lactation.

The inganci da kuma aminci daga cikin miyagun ƙwayoyi a lura da yara da ba a gano, don haka ba su yi amfani da shi a cikin ilimin aikin likita na yara.

illa

Mycophenolate mofetil iya tsokana wasu illa. Its amfani a hade tare da cyclosporine da corticosteroids iya sa zawo, amai, leukopenia da sepsis. A wasu lokuta, akwai ci gaban lymphoma da sauran malignancies, musamman na fata.

Bugu da kari, duk dashi marasa lafiya ne a hadarin cututtuka, wanda aka tsokane ta opportunistic pathogens. Mafi na kowa daga cikinsu akwai herpes, candidiasis da cytomegalovirus.

Sauran m halayen iya bayyana kansu a cikin irin shingles, urinary fili cututtuka, rhinopharyngitis, hyperthermia, mahaukaci hanta aiki, esophagitis, gastrointestinal zub da jini, da ciwon ya kama daga cikin manya na numfashi fili, tari, ciwon kai, gastroenteritis, gajiya, sinusitis, na baka candidiasis , pancreatitis, pancytopenia, neutropenia, da sauransu.

Akwai barazana mai tsanani da kuma a wasu lokuta ma m mamaki kamar tarin fuka, kwayan endocarditis, atypical mycobacterial cututtuka.

Dosing da Administration

Yadda za a yi amfani da miyagun ƙwayoyi "Mycophenolate mofetil"? Umarnin a haɗe da shi, samar da wadannan bayanai.

Ga masu rigakafin koda kin amincewa. A farko kashi na wakili da za a gabatar a cikin jiki a cikin sa'o'i 72 bayan dasawa gudanar. Daga bisani, da mãsu haƙuri za bukatar daukar 1 g sau biyu a rana wajen.

Kamar wancan mycophenolate mofetil mafi yawa ana gudanar a hade tare da corticosteroids da cyclosporin.

Ga masu rigakafin zuciya kin amincewa. A farko kashi ya kamata a dauka ba daga baya fiye da 5 kwanaki bayan tiyata gudanar. Daga bisani wani zama dole adadin da samfurin ne 1.5 g sau biyu a rana

yawan abin sama

Data a kan miyagun ƙwayoyi yawan abin sama, "mycophenolate mofetil," ba samuwa.

Yana nufin shi ne ba zai yiwu ba ga kacokan daga cikin jiki ta hanyar hemodialysis. Kwayoyi da kisa bile acid (cholestyramine) na iya sauƙaƙe kau da IFC kwayoyin, kara da tukar tumbi.

Features na aikace-aikace

Bayan ganewa na wani haƙuri neutropenia kamata a rage kashi da hankali saka idanu haƙuri da kiwon lafiya matsayi ko soke magani mycophenolate mofetil.

A gaban mai tsanani kullum na koda gazawar da ya kamata a hankali saka idanu da jihar na kiwon lafiya da kuma ba ya wuce a kalla kashi wajen, wanda a cikin wannan hali nawa to 2 g per day.

Tsofaffi da marasa lafiya (shekaru 65) da shawarar yin amfani da 1 g da miyagun ƙwayoyi, sau 2 a rana.

Bayani game da tasiri na jamiái a lura da marasa lafiya da na koda gazawar da suka yi mashi a hanta dashi ko zuciya, da ya bace. Har ila yau, babu wani bayani game da yadda miyagun ƙwayoyi ne tasiri ga marasa lafiya da hanta raunuka wanda underwent zuciya dasawa da aka yi.

rigakafi

A cikin wani hali ba zai iya bude kwantena a cikin shiri. Ya kamata kauce wa kai tsaye lamba tare da foda: shi inhalation, lamba tare da fata, ko mucous membranes. Idan, duk da haka, shi ya faru, ya kamata nan da nan ya wanke ya shafa yankin tare da sabulu da kuma ruwa.

analogues na kudi

Shin akwai magunguna da za su iya maye gurbin samfurin "Mycophenolate mofetil"? Analogs, ba shakka, akwai. Suna da wannan INN (International Nonproprietary Name), ko ATC code. Za kawai zama dan kadan daban-daban bakan na aiki da kuma tsabar kudi halin kaka.

Mafi shahara ne da wadannan kwayoyi:

• "Baksmun". Amfani da a hade tare da cyclosporine da corticosteroids don rigakafin kin amincewa da zuciya, hanta ko kodan bayan dasawa.
• "Zenapax." Ana amfani da su hana kin amincewa da wani koda dashi a hade tare da cyclosporine GCS.
• "Imusporin". Amfani ga yin rigakafi da magani daga transplanted gabobin da kuma bargo da a rheumatoid amosanin gabbai, na ciki uveitis, Behcet ta cuta, tsari lupus erythematosus, da kuma sauran cututtuka.
• "Imufet". Kazalika da babban miyagun ƙwayoyi, wakili gudanar a hade tare da corticosteroids da cyclosporin domin hana kin amincewa da wani transplanted koda ko hanta.
• "Layfmun". Tool yana da fadi bakan na mataki. Ana iya amfani da wa yin rigakafi da magani daga kin amincewa da transplanted gabobin ta jiki da kuma bargo, kazalika da amosanin gabbai, nephrotic ciwo, aiki siffofin tsari lupus erythematosus, Behcet ta cuta, na ciki uveitis da kuma sauran cututtuka.
• "Mifenaks". Alamomi ga amfani ne guda a matsayin cewa daga cikin manyan wajen.
• "Mifortik". Tsara don hana kin amincewa da transplanted koda.
• "Mofilet". Alamomi da kuma amfani ne irin wannan da mycophenolate mofetil.
• "Panimun". Amfani a cikin dasawa daga cikin huhu, zuciya, koda, bargo, pancreas, kazalika da a wasu cututtuka.
• "CellCept." Yana za a iya sanya a lõkacin da wata koda dashi.
• "Sertikan". An nuna for koda dashi ko zuciya marasa lafiya da matsakaici ko low immunological hadarin.
• "Tsikloral". Amfani a tare da sauran kwayoyi a sashin jiki transplants.
• "Ekvoral". Ana amfani da a cikin dasawa da parenchymal gabobin, kazalika don rigakafin kin amincewa bayan dasawa.

Duk da cewa su duk da irin wannan irin mataki, kafin ya maye gurbin babban miyagun ƙwayoyi zuwa wani, dole ne ka farko tuntubar, kuma ka yi shãwara da likita.