Carbonic anhydrase hanawa: inji na mataki na ido saukad for glaucoma

Carbonic anhydrase hanawa ne diuretics, wanda ba su yi amfani da matsayin diuretics ko mochegonki. Nuni ga wadannan kwayoyi ne glaucoma. Bari mu bincika a cikin mafi daki-daki cikin rare su.

Acetazolamide (Acetazolamide)

Yana yana da diuretic Properties. Tsaya a nan carbonic anhydrase koda proximal tubules rage reabsorption na K, Na kuma ruwa (diuresis haddasa karuwar), shi take kaiwa zuwa wani karu a Bcc da kuma na rayuwa acidosis. Carbonic anhydrase depresses da ciliary jiki da take kaiwa zuwa wani ragewan daga cikin intraocular matsa lamba, da kuma rage mugunya ruwa-ruwa mutumci a cikin kwakwalwa sa antiepileptic aiki. Yana yana da kyau sha daga gastrointestinal fili, Cmax a cikin jini a sa'o'i biyu. Effect iya wuce har zuwa 12 hours. 40-60% lowers IOP da kuma rage samar da intraocular ruwa.

Alamomi & Sashi

Babban alamomi: ocular hauhawar jini, glaucoma. A glaucoma, da a ciki dauka a kan 0.125-0.25 g 1-3 sau a rana, kullum kwanaki 5, bayan wanda yana bukatar wani yini biyu hutu.

Side effects: tashin zuciya, asarar ci, zawo, allergies, illa gabar touch, paraesthesia, tinnitus, drowsiness. Duk wannan zai iya fararwa carbonic anhydrase hanawa. Shirye-shirye ne ma contraindications. Wannan wuce kima ji na ƙwarai (zuwa sulfonamides ciki har da), Addison ta cuta, jaraba ga acidosis, m cutar hanta da koda cuta, ciki, da ciwon sukari mellitus, uremia.

Anfani hani: huhu embolism, na huhu emphysema (yiwu kara acidosis).

Da miyagun ƙwayoyi: Allunan samar a Poland Polpharma "Diakarb" zuwa 0.5 g

Dorzolamide (dorzolamide)

Damuarn carbonic anhydrase isoenzyme II Activity (Kaddamar reversible hydration dauki na carbon dioxide da carbonic acid dehydration) ido ciliary jiki. Mugunya intraocular danshi ne rage by 50%, slows saukar da samuwar bicarbonate ions, kuma partially rage sufuri na ruwa da kuma sodium. Rage da kashi 38% na samar da intraocular m cewa ba zai tasiri a outflow. Yana ratsa cikin eyeball yawanci ta hanyar da reshe, cornea ko sclera. Partially tunawa a cikin tsari jijiyoyin bugun gini gado na Eye mucosal (m faruwa diuretic da sauran effects hankula sulfonamides). Bayan da abu ya samu a cikin jini, hanzari ratsa cikin ja da maikacin jini, wadda dauke da manyan yawa na carbonic anhydrase II. Dorzolamide 33% daure su jini sunadaran. Matsakaicin hypotensive sakamako bayyana bayan instillation ta 2 hour da Stores shi 12 hours. Lokacin da backfilling zuwa sau 2 a 9-21% a kowace rana rage-rage intraocular matsa lamba a lokacin da shuka kamar yadda sau 3 a rana - to 14-24%. Akan rage intraocular matsa lamba ta yin amfani da wani 2% bayani za a iya yin iyakar 4,5-6,1 mm Hg. A bayani na 3% zai zama kasa tasiri saboda shi zai sauri wanke daga cikin conjunctival rami a matsayin shi sa karfi tearing. A tare da tare da nada timolol yana da wani ƙarin pronounced sakamako daga 13 zuwa 21%. Kadan sakamako a kan jini da kuma zuciya rate da carbonic anhydrase hanawa. Diuretics wannan kungiya da ba a amfani ga manufar da aka nufa. A wannan daga baya.

Alamomi & Sashi

Alamomi: firamare da sakandare bude-kwana glaucoma, ocular hauhawar jini. Da miyagun ƙwayoyi ne nuna 1 drop 2-3 sau a rana.

Side effects: paresthesia, nauyi asara, ciki, fata rashes, aplasticheskayaanemiya, agranulocytosis, gajiya, ciwon kai, mai guba epidermal necrolysis, m iyawa a bakin, tashin zuciya, karuwa a cikin kauri daga cikin cornea, iridocyclitis, blepharitis, keratitis, conjunctivitis, photophobia, Heart hangen nesa, itching da kuma tingling abin mamaki a cikin idanu, rashin jin daɗi, Stevens - Johnson ciwo, kona, na ruwa idanu.

A carbonic anhydrase hanawa (ido saukad) yana da wadannan contraindications: wuce kima ji na ƙwarai (zuwa sulfonamides ciki har da), yara, m cutar hanta da koda cuta, daukar ciki da nono.

Shiri: eyedrops "Trusopt" dauke da 1 ml na 20 MG dorzolamide hydrochloride bayani. vials - 5 ml. An samar a cikin Netherlands ta Merck Sharp & Dohme.

Carbonic anhydrase hanawa: Brinzolamide (brinzolamide)

M shafi na carbonic anhydrase da ciwon da ikon lokacin amfani da topically zuwa gagarumin raguwa da kuma kula da IOP. Brinzolamide mallaka high selectivity for carbonic anhydrase II, da kuma mafi m jiki Properties yadda ya kamata shiga cikin ido. Lokacin da aka kwatanta da dorzolamide da atsetozolamidom shi gano cewa brinzolamide - mafi m abu rukuni na carbonic anhydrase hanawa. Akwai shaida da cewa Topical ko igiyar jini gwamnati na brinzolamide take kaiwa zuwa wani ci gaba na na gani faifai. Kuma shi rage ta wani talakawan of 20% IOP. Yana ba ya aiki duk carbonic anhydrase hanawa. Ginshikai na mataki na musamman daga brinzolamide.

Alamomi da kuma sashi

Alamomi: ocular hauhawar jini, bude-kwana glaucoma. Yi amfani da sau 2 a rana domin a drop.

Side effects: dandano da batattun, kasashen waje jiki abin mamaki, Heart hangen nesa kan instillation (lokaci) da kuma kona abin mamaki. Canjawa wuri gida mafi alhẽri daga dorzolamide.

Contraindications: wuce kima ji na ƙwarai to da miyagun ƙwayoyi (zuwa sulfonamides ciki har da), yara shekaru, daukar ciki da nono.

Shiri: eyedrops "Azopt" dauke da 1 ml na a dakatar da 10 MG brinzolamide. Capacity vials na 5 ml. Samar a cikin USA ta Alcon.

Me kuma suke carbonic anhydrase hanawa?

prostaglandin Kalam

Latanoprost (latanoprost) - prostaglandin tsoka mai amsa sigina zabe agonist. Qara outflow na intraocular ruwa ta hanyar da uvea, wadda take kaiwa zuwa wani ragewan daga intraocular matsa lamba. Tasiri a kan samar da ruwa-ruwa dara ba zai taimaka. Iya canza girman da almajiri, amma kawai dan kadan. Lokacin da backfilling ratsa a cikin nau'i na isopropyl ether ta cikin cornea kuma akwai hydrolyzed zuwa jihar a ilimin aiki acid, wanda za a iya bayyana a farko 4 hours a intraocular ruwa da kuma a cikin jini a farkon hour. 0,16l / kg - juz'i na rarraba. Biyu sa'o'i bayan Bugu da kari cimma cincirindo a cikin ruwa-ruwa dara, bayan wanda shi ne rarraba zuwa farkon gaban kashi, Ina nufin eyelids da conjunctiva, sa'an nan ya shiga cikin na baya sashi (a kananan yawa). The aiki form a cikin tsokoki na ido ne kusan ba metabolized, yafi a cikin hanta biotransformation. Advantageously, metabolites ake excreted a cikin fitsari. Bari mu dubi wasu daga cikin carbonic anhydrase hanawa.

Unoprostone (unoprostone)

Isopropyl unoprostone ne wanda aka samu da wani docosanoid hanzari rage intraocular matsa lamba (IOP) ta amfani da latest pharmacologic inji. Ba tare da canza lokaci samar da intraocular ruwa, facilitates ta outflow. Nazarin ya nuna cewa, idan aka kwatanta da 0.5% timolol maleate, isopropyl unoprostone yana kama ko ma mafi alhẽri aiki don rage IOP. Da miyagun ƙwayoyi ba zai tasiri a masauki, kuma ba sa rage jini ya kwarara a cikin ocular kyallen takarda, miosis ko mydriasis. corneal farfadowa da bata lokaci ma ba a gano. Bayan Topical canzawa isotropy unoprostone aka ba gano a cikin jini.

carbonic anhydrase hanawa ga glaucoma ya kamata a wajabta kawai da wani likita, kai-magani ake ba da izini.