Protamine sulfate: Description da User

Me ne mai magani abu kamar protamine sulfate? umarnin ga ta amfani, kazalika da siffar da kuma shaidar da kudi za a jera a kasa.

Abun da ke ciki, description, fom

Mene ne protamine sulfate? Wannan bayani da aka dakatar a matsayin yellowish ko colorless m ruwa nufi ga igiyar jini gwamnati. A shirye-shiryen bisa wannan magani yana da wannan sunan, da kuma kara daukar wani ruwa don yin allura.

A sayar da "Protamine sulfate" da aka kawota a vials da aka sanya a cikin cell shaci daga polyvinyl chloride fim, wanda aka cushe a kwali kwalaye. Har ila yau a cikin kunshin aka sanya umarnin don amfani da ampoule mabudin.

Drug mataki

Mene ne protamine sulfate? Guide rahoton cewa wannan heparin antagonist (musamman). 1 MG na abu iya neutralizing haƙuri da jini na game da 80-115 iu na heparin.

Action rahoto nufin bayan igiyar jini allura zai fara nan da nan, kuma yana for game da sa'o'i biyu. Complexation da miyagun ƙwayoyi saboda da yawa daga cationic kungiyoyin cewa daura da anionic cibiyoyin heparin.

Bisa ga umarnin da protamine sulfate a cikin mutane da aka complexed heparin-protamine, wanda ya karya don saki da karshen.

A yawan abin sama da wannan yana nufin wani haƙuri za a iya rage muhimmanci jini clotting, tun dauke aiki wakili halitta farfado da wani babban anticoagulant aiki.

Pharmacokinetics nufin

Abin yana da sanadin motsi kaddarorin da heparin protamine sulfate? A cewar masana, shi yana pharmacokinetic kaddarorin da miyagun ƙwayoyi ba a karatu. Saboda haka, ba su da wakilci a cikin manual.

Alamomi ga bayani

A wasu lokuta, da haƙuri igiyar jini bayani "Protamine sulfate" za a iya sanya? Aikace-aikace na nufin wannan ne aka nuna:

• kafin tiyata a mutanen da shan heparin ga warkewa dalilai.
• a hyperheparinemia.
• ga zub da jini da ke faruwa saboda heparin yawan abin sama.
• bayan da aiki a kan jini da kuma zuciya tare da extracorporeal wurare dabam dabam.

Haramcin zuwa manufa bayani

Drug "Protamine sulfate" (takardar sayen magani saya da shi dole ne rubũta likita) an contraindicated a cikin wadannan lokuta:

• tare da thrombocytopenia.
• high ji na ƙwarai zuwa ga abubuwa na miyagun ƙwayoyi.
• m hypotension.
• nakasar ko idiopathic hyperheparinemia (a cikin wannan jiha da magani ne m, da kuma iya muhimmanci inganta jini).
• gwamnati na insulin da sauran kwayoyi dauke da wani protamine sulfate.
• rashin lafiyan halayen ga kifi kayayyakin, ciki har da wani tarihi.
• adrenal insufficiency.

Ba za mu iya ce cewa kwarewa na likita yin amfani da wannan kayan aiki a yara yana da iyaka.

A lokacin daukar ciki da kuma lactation "Protamine sulfate" za a iya amfani da su. Duk da haka, wannan ya kamata a yi kawai a yanayin, idan sakamakon da magani ne muhimmanci mafi girma fiye da m hadarin da tayin ko yaro.

Shiri "Protamine sulfate": umarnin don amfani da

An duba bayani ya kamata a gudanar da jinkirin IV drip ko bolus. Kamar wancan ne da kudi na gwamnati kada wuce 5 MG da minti. Sauri gabatarwar da miyagun ƙwayoyi iya haifar da haƙuri anaphylactoid dauki.

Sashi na medicament dogara a kan hanyar da gwamnati. A lasafta kashi ya kamata a narkar da a 300-500 ml na 0.9% ƙarfi sodium chloride bayani. An tsananin haramta shiga fiye da 150 MG na miyagun ƙwayoyi domin 60 minutes.

• Tare da bolus allura sashi na protamine sulfate an rage dangane da lokacin da ya wuce daga gwamnatin heparin. Wannan shi ne saboda gaskiyar cewa karshen an ci gaba da cire daga jikin mutum.
• Idan heparin aka gudanar igiyar jini drip, shi wajibi ne don dakatar da jiko da kuma amfani game da 20-30 MG na protamine sulfate.
• Lokacin da subcutaneous allura heparin sashi na protamine sulfate 1-1.5 MG 100 Iu heparin. Kamar wancan ne na farko 25-50 MG ya kamata a sannu a hankali gudanar intravenously, da kuma sauran yawa - igiyar jini drip for 8-17 hours. Shi ne kuma zai yiwu intermittent gwamnati, amma zai bukaci m saka idanu na APTT.
• Lokacin da wani m baki a yanayin saukan extracorporeal wurare dabam dabam bayani dauke sashi ne 1.5 MG zuwa 100 ME heparin.

Matsakaicin tsawon na far na kudi ne 3 days.

Action da-hali

Iya da protamine sulfate to sa illa halayen? Manual jihohin da a general wannan magani aka gwada da kyau jure da marasa lafiya. Duk da haka, a wasu lokuta, shi zai iya har yanzu sa illa effects a kan wani ɓangare na rigakafi, zuciya da jijiyoyin jini da kuma narkewa kamar tsarin, kazalika da fata:

• bradycardia, wani raguwa a jini.
• amai da tashin zuciya.
• itching, fata na gaggawa da ci gaba da anaphylactoid halayen.
• jin zafi, jin short na numfashi, da kuma yankin Flushing na fata.

Overdoses da kuma hulda da sauran kwayoyi

An duba bayani nufi ga igiyar jini gwamnati ne m tare da penicillins da cephalosporins. Ganin cewa yana da wani antagonist, low kwayoyin nauyi heparins, aiki miyagun ƙwayoyi na iya kara tsawon da tsanani da mataki na ba-depolarizing tsoka relaxants.

An yawan abin sama da miyagun ƙwayoyi iya hade tare da zub da jini. Wannan shi ne saboda cewa da dũkiyõyinsu a tambaya yana da babban anticoagulant aiki. A wannan yanayin, dauke da fitar symptomatic magani ake bukata.

takamaiman bayanai

Abin da ya kamata ka sani kafin ka shigar da irin wannan bayani kamar yadda protamine sulfate? Masana sun ce cewa yin amfani da wannan magani ya kamata a cigaba da sanya idanu likita wanda dole ne a kai a kai saka idanu da jini clotting haƙuri.

Kafin gabatarwar da miyagun ƙwayoyi zama dole don tabbatar da isasshen haƙuri da jini girma. Wannan shi ne saboda gaskiyar cewa hypovolemia muhimmanci ƙara hadarin auka.

Storage yanayi na samar da Pharmacy, shiryayye rayuwa

Ko da yardar kaina sayar a Pharmacy miyagun ƙwayoyi "Protamine sulfate '? Girke-girke a Latin ko Rasha harshen, tabbata a nuna da harhaɗa magunguna, in ba haka ba da miyagun ƙwayoyi da aka saki.

Adanar nufin dauke zama dole a isar yara da kuma kare daga hasken rana inda iska zafin jiki ne tsakanin 4 da kuma 10 digiri. Ya kamata kuma a lura da cewa igiyar jini bayani "Protamine sulfate" a wani hali dole ba za a daskarewa.

Shiryayye rayuwar wannan miyagun ƙwayoyi ne 4 shekaru daga ranar yi. Kada ka yi amfani da shi bayan da karewa na wannan lokaci.

Drug analogues da kuma sake dubawa game da shi

Analogues a cikin rahoto kayayyakin aiki, ba su da yawa sosai. A igiyar jini bayani za a iya maye gurbinsu da kwayoyi kamar "Protamine" da "Protamine-Verein".

Game da mabukaci sake dubawa, kusan dukkan su ne tabbatacce. "Protamine sulfate" - wannan ne mai matukar inganci da tasiri wajen samuwa ga kowa da kowa. An wannan ra'ayi ne shared da yawancin marasa lafiya. Suna da'awar cewa wannan magani ba shi ba da heparin to hana aiwatar da jini clotting, inganta haƙuri da yanayin a lokacin nauyi zub da jini.

Kamar yadda ya isa yabo na wannan magani hada ta m da kuma shafe tsawon sakamako. Bugu da ƙari kuma, a cimma wata warkewa sakamako ga mai haƙuri ake bukata don gudanar da wani dogon lokacin da magani. Matsakaicin tsawon amfani da wannan magani ne kwanaki uku.