Abubuwan da ake kira Zoledronic acid: aikin maganin magunguna da analogues

An san cewa bisphosphonates na da dukiya don hana ci gaban kasusuwan kasuwa da kuma hana asarar nama. Daya daga cikin mafi kyau kwayoyi na wannan rukuni shine zoledronic acid. Akwai kuma shaida cewa wannan magani yana da hana maye gurbin antigenogenesis, mamayewa na rikici, haɗuwa da kwayoyin ƙwayoyin cuta a cikin kashi kashi, haifar da apoptosis, da kuma synergism da chemotherapy ana kiyaye.

Haɗuwa na 1 kwalban

Hadin acid acid monohydrate - 4.26 MG, excipients - sodium citrate, D-mannitol.

Pharmacology

Inhibitor na kashi resorption. Abubuwan da ake kira Zoledronic acid ne na sabon jinsin bisphosphonates na babban aji. Yana da tasiri mai mahimmanci a jikin nama. Rage aiki na osteoclasts, ba tare da haddasa mummunan sakamako a kan samuwar da sauran halaye na kashi nama. Sakamakon bisphosphonates akan kashi yana dogara ne akan babban kamanni da nau'in nama na kashi, amma ainihin ma'anar kwayoyin da ke bada aikin hana aikin osteoclast ba a taɓa nazari har yau ba. Har ila yau yana da tasirin maganin antitumor, wanda ke samar da inganci a cikin ƙananan ƙananan ƙwayoyin cuta.

A cikin vitro, an gano cewa zoledronic acid, yaduwar apoptosis da yaduwar kwayoyin halitta, yana da tasirin antitumor kai tsaye a kan myeloma, da kuma kwayoyin cututtuka na nono, yayin da rage hadarin matakan ƙwayar cuta. Har ila yau, zoledronic acid yana da dukiyoyi don rage yawancin mai alli a cikin magani tare da hypercalcemia, wanda ya haifar da ciwon.

Indiya don amfani

• Osteolytic foci a mahara foci na myeloma.
• Rashin ƙwayar cutar, ƙwararru, ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.
• Hypercalcemia, wanda aka haifar da mummunar horo.

Contraindications

• Tashin ciki da kuma nono.
• Renal rashin cikakken.
• Yara da matasa (aminci na amfani ba a kafa) ba.
• Kayan shafawa ga bisphosphonates da kuma zoledronic acid.
• Kariya: koda tabarbarewa, Bronchial fuka, hanta gazawar.

Sakamako na gefen

Anuri, thrombocytopenia, ciwon kai, rashin hankali, conjunctivitis, nausea, anorexia, vomiting, zawo, ciwon zuciya, arthralgia, hypophosphatemia, hypocalcemia, zazzabi, ciwon mura, asthenia, wadata. A cikin marasa lafiya tare da zoledronic acid, an yi amfani da osteonecrosis na jaw a wasu lokuta (yawancin lokuta bayan an kwantar da baki).

Hanyar aikace-aikace

Intravenous da drip na mintina 15, amma ba kasa ba. Metastases mahara myeloma shawarar kashi na 4 MG zarar wata daya. Tare da hypercalcemia, wanda aka haifar da mummunar ciwon sukari, kashi yana da 4 MG sau daya.

Umurni na musamman

Da zarar da miyagun ƙwayoyi gudanar, ya zama dole don sarrafa taro na magnesium, phosphorus, creatinine da alli a jini magani. Idan za ta yiwu, yakamata a kauce wa hanyoyi na hakori.

Hadedronic acid. Analogues

Shirye-shirye "Actonel", "Aneldronat", "Aredia lyophilizate", "Bonviva", "Bonnronat", "Bonefos", "Klobir", "Xidifon", "Lindron", "Ostalon", "Ostealen", "Ostererepair" "Pamidronate", "Pomegara", "Risendros", "Strogos", "Tevanan", "Forosa", "Fosamax", "Fosfoteh", "Rizarteva."

Hadedronic acid. Farashin:

Yawancin lokaci, shafuka da ke rarraba magunguna a cikin iyakar dokokin suna nuna farashin kaya. Amma, abin ban mamaki shine, farashin azaman zoledronic acid yawanci ana nunawa sosai. Amma kimanin kimanin kimanin 14,000 rubles da kwalban. An sayar da shi ne a kantin magani kawai akan takardar sayan magani.

Bayanan da aka gabatar a sama an tsara ne don haɓaka ma'aikatan kiwon lafiya. Wannan labarin a kan zoledronic acid baya maye gurbin shawarar likita, kuma ba zai iya tabbatar da wani sakamako mai kyau na miyagun ƙwayoyi ba.