Da miyagun ƙwayoyi "valparin": umarnin don amfani, abun da ke ciki, ma'ana, equivalents. Sharhi kan shirye-shiryen

Me ya sa na bukatar magani "valparin"? Umarnin don amfani, ma'ana, kuma alamomi na wannan miyagun ƙwayoyi da aka bayyana a cikin wannan labarin.

A siffar da kuma abun da ke ciki na

Abin da nau'i ne muhimmi a da miyagun ƙwayoyi "valparin"? Tablet - shi ne a cikin wannan nau'i na da miyagun ƙwayoyi a tambaya za a iya saya a kantin magani. Sun nuna a shafe tsawon mataki, a zagaye biconvex siffar, da kuma wani farin launi shafi.

Wannan ɓangare na miyagun ƙwayoyi "valparin"? Guide tanadi cewa da kayan aiki ya ƙunshi valproic acid da kuma sodium valproate. Yana kuma ya hada da wadannan excipients: glycerol, colloidal silicon dioxide, evdragit E-100, hydroxypropylmethylcellulose, polyethylene glycol 1500, ethylcellulose, sodium saccharin, silicon dioxide hydrate, evdragit BA-30D, titanium dioxide da talc.

Saya Allunan za a iya kyan gani, a tube na 10 guda a kwali cuta bi da bi.

A kwayoyi

Ta yaya miyagun ƙwayoyi "valparin"? Umurnai na amfani (abun da ke ciki na nufin an bayyana a sama) ya furta cewa, shi ne wani anticonvulsant miyagun ƙwayoyi. Ya ƙunshi wani sodium valproate abun ciki na bunkasa Gaba a cikin kwakwalwa, wanda na taimaka wa ta karuwa a postsynaptic neurons.

Ya kamata mu ma lura da cewa bangaren tambaya musababin da kai na potassium ions fadin neuronal membranes. Wannan tsari mai cike da ci gaba da kuma yaduwar farfadiya zumudi a jijiya zaruruwa.

Ya kamata kuma a ce cewa sodium valproate yana da wani anticonvulsant sakamako a daban-daban iri epilepsy.

Drug "valparin" ba mallaki magani mai kantad da hankali da kuma hypnotic effects, kuma ba su yanã raunanar da cibiyar na numfashi. Bugu da kari, ta aiki sashi ba shi da wani illa effects a kan zuciya rate, yanayin jiki na haƙuri, da jini da kuma koda aiki.

A sanadin motsi kaddarorin da miyagun ƙwayoyi

Mene ne pharmacokinetic halaye na da miyagun ƙwayoyi yana da "valparin"? Guide ikirarin cewa bayan shan kwayoyi a ciki a sarrafawa saki na aiki abu fara nan da nan, da kuma bayan 2-8 hours, ya kai wani matsakaicin jini matakin.

Bioavailability nufin dauke 100%.

A warkewa sakamako daga cikin miyagun ƙwayoyi bayyana ne kawai bayan kai da valproic acid taro a jini, daidai 45-100 MG / l. Za a yaba cewa warkewa da kuma pharmacological ayyuka na hanyar sarrafawa saki core bangaren ba ko da yaushe dogara ne a kan jini yawa.

Communication dauke miyagun ƙwayoyi zuwa jini sunadarai ne kamar 85-90%. An metabolized a cikin hanta da kuma shi ne fitarwa tare da fitsari. A wannan na farko-izinin metabolism aka kiyaye.

Half-rai na wakili ne game da 9-20 hours. A yara, wannan lokaci ne rage.

Alamomi ga m

A karkashin abin da yanayi mafi tasiri magani behaves "valparin"? Umarnin don amfani, real gogaggen kwararru rahoton cewa ya ce medicament aka samar musamman domin lura da jimlace epilepsy, ciki har da wadannan iri-haren:

• myoclonic.
• absences.
• atonic.
• tonic-clonic.

Har ila yau, wannan magani an wajabta, a m epilepsy, kuma mafi musamman, a:

• secondary jimlace seizures.
• a hade ko sauki seizures.

Bugu da kari, sau da yawa Allunan kyan gani, yi amfani da lokacin da wani takamaiman syndromes (Lennox-Gastaut ciwo, West).

Haramta yin amfani da Allunan

Yana yana da wani contraindications miyagun ƙwayoyi "valparin"? Bisa ga umarnin daga kayan aiki, akwai mutane da yawa hani ga yin amfani da:

• a lokacin daukar ciki.
• tsanani da cuta a cikin pancreas.
• thrombocytopenia.
• hepatitis m ko na kullum.
• porphyria.
• aiki hepatitis lokuta (miyagun ƙwayoyi Farawa).
• nono.
• shekaru yara har zuwa shekara uku.
• hypersensitivity da miyagun ƙwayoyi, ciki har da zuwa valproic acid.

Anticonvulsant "valparin": umarnin don amfani da

A sashi daga cikin miyagun ƙwayoyi da aka zaba akayi daban-daban, dangane da jiki nauyi da kuma shekaru na haƙuri.

Yawanci, domin adult farawa kashi ne 600 MG na da miyagun ƙwayoyi a kowace rana. A cikin wadannan wannan lambar karu da 200 MG (kowane kwanaki uku a cimma da ake so sakamakon).

Multiplicity karža yana nufin a karkashin shawara ne 1-2 sau per day. Matsakaicin shawarar sashi ne 1-2 g da miyagun ƙwayoyi a kowace rana.

Allunan "valparin", umarnin don amfani da suna dauke a cikin wannan takarda ya kamata a yi lõma da matsayin dukan, sha da karamin adadin dumi ruwa.

A tsofaffi mutane da dosing regimen wannan kayan aiki ne kama da dosing regimen a adult marasa lafiya, amma zaba a kan wani mutum akai.

Domin jariran yin la'akari 20 kg na farko kashi na medicament ne 400mg kowace rana. Wajibi ne a kara yawan hankali ga cimma da ake so sakamakon (game da 20-30 MG / kg per day, a 1-2 allurai).

Yaro yin la'akari har zuwa 20 kg sanya anticonvulsant magani da aka haramta.

Ayyuka da-hali

Mene ne illa dalili "valparin" kwamfutar hannu? Umurnai na amfani notifies cewa ci wannan magani a adam marasa lafiya na iya fuskanci a ke so effects:

• Rashin lafiyan halayen: Stevens-Johnson ciwo, fata na gaggawa, erythema multiforme, pruritus, fata, photosensitivity.
• Tsarin narkewa kamar: tashin zuciya, hepatitis, amai, maƙarƙashiya, zawo, pancreatitis.
• Haihuwa tsarin: amenorrhea sakandare, sababbu haila.
• CNS: coma, tremors, ataxia, illa sani.
• hemopoietic tsarin: anemia, platelet tari hanawa, thrombocytopenia, leukopenia, neutropenia, rage fibrinogen.
• Sauran: nauyi riba, gashi hasara, magani creatinine, hyperammonemia.

yawan abin sama anticonvulsant

Abin da cututtuka za su iya faruwa a lokacin da shan high allurai da miyagun ƙwayoyi "valparin"? Umurnai na amfani (Allunan za a iya saya a wani kantin magani a kan sayan magani) ya bayar da hujjar cewa zuwa ranar ganganci ko mai haɗari yawan abin sama da miyagun ƙwayoyi a karkashin shawara da aka ruwaito da wuya. Matsayin mai mulkin, da take hakkin da dosing da miyagun ƙwayoyi taimaka wa bayyanar tashin zuciya, juwa ko jiri, amai, zawo, na numfashi ciki, coma, da kuma hyporeflexia.

Don kawar da irin wannan yanayi da haƙuri da aka wajabta ciki lavage da kuma kunna gawayi. Idan ya cancanta, da mãsu haƙuri magani ne da za'ayi a cikin nau'i na symptomatic far da hemodialysis.

Hulda da sauran kwayoyi

Ko shiga cikin hulda da sauran kwayoyi magani "valparin"? Umurnai na amfani sanar da haƙuri da cewa sodium valproate to fadada sakamakon antipsychotics, antidepressants da antiepileptic kwayoyi.

Ba kamar sauran anticonvulsants , dauke ba miyagun ƙwayoyi inganta hanta enzyme shigar da, sabili da haka ba rage tasiri na baka hana.

A layi daya liyafar na "warfarin" da kuma sodium valproate rage yawan dauri ga jini sunadaran farko.

The aiki miyagun ƙwayoyi abu ne dauke iya canza jini yawa na lamotrigine, kuma phenytoin. Idan aka hada tare da Kalam na acetylsalicylic acid anticoagulant da antiplatelet sakamako ne inganta.

Tare da lokaci daya amfani "valparin" daga ethanol da sauran kwayoyi da depress CNS rufe (msl, Mao hanawa ne tricyclic antidepressants, antipsychotic kwayoyi) na iya inganta CNS ciki.

Barasa da kuma sauran hepatotoxic kwayoyi kara hadarin hanta lalacewa.

An sano halitta qara rabin-rai "lamotrigine" da kuma slows saukar da metabolism da kuma cike da hanta enzymes. A dangane da wannan rabin-rai da miyagun ƙwayoyi iya ƙara har zuwa 70 hours a adult marasa lafiya da kuma har zuwa 45 hours - da yara.

"Valparin" shi ne iya rage yarda "zidovudine" by game da 40%. Bugu da ƙari, ta rabin-rai ba ya canza.

Mao hanawa antidepressants, tricyclic da antipsychotic kwayoyi (neuroleptics), kazalika da sauran kwayoyi da ƙananan kãmun bakin kofa, da yawa rage tasiri na dauke medicament.

Nono da kuma ciki

A cewar masana, da yin amfani da miyagun ƙwayoyi "valparin" a lokacin gestation ne kawai zai yiwu idan akayi amfani ga nan gaba uwãyensu muhimmanci wuce hadarin m zuwa jariri.

Lokacin da karbar magani a lokacin daukar ciki, tabbatar da gudanar da wani musamman prenatal monitoring da tayin.

Amfani da miyagun ƙwayoyi a lokacin lactation ba da shawarar.

Specific bayanai

Kafin ka fara lura da kudi, tabbatar da tuntubar tare da likita.

A kan aiwatar da samun anticonvulsant magunguna na bukatar yau da kullum saka idanu na bilirubin a cikin jini, amylases da platelets, kazalika da hanta transaminases (kowane watanni 3).

A cewar masana, valproic acid ne iya inhibiting platelet tari. Wannan ƙwarai qara hadarin ya karu jini coagulation lokacin zub da jini. Wajibi ne a yi la'akari da alama na matsalolin da ake dangantawa da zub da jini a cikin postoperative zamani, a cikin mutanen da samun sodium valproate.

Idan dogon lokacin da magani daga wannan magani a marasa lafiya na iya ci gaba maras wata-wata na jini da kuma hematoma kafa. A wannan yanayin, da kwayoyi ya kamata a tsaya nan da nan.

Kamar yadda aka ambata a sama, sodium valproate, wani magani sau da yawa yana sa pancreatitis, da kuma inganta rushewa daga hanta aiki (yawanci a cikin na farko 6 months magani). A wannan batun, a farkon far wajibi ne don saka idanu da matsayi na pancreatic ciwon daji haƙuri, kazalika da wa a kai a kai saka idanu hanta aiki gwaje-gwaje, da kuma matakin na prothrombin.

Cuta da hanta da kuma hanta gazawar a marasa lafiya samun sodium valproate za a iya lura a yara tare da epilepsy a rayuwa da kuma degenerative cututtuka, shafi tunanin mutum retardation da kwayoyin kwakwalwa nama Pathology.

A cikin kallo na da ãyõyi a matsayin lethargy, alama wani rauni, kumburi, da kuma amai, jaundice, ya kamata nan da nan yanke amfani da medicament.

A lura da "valparin" haƙuri kamata ya mai da hankali a lõkacin da aiki tare da m kayan. Wannan shi ne saboda cewa da aiki medicament ne iya rage taro.

Sharuddan da yanayi na ajiya

Anticonvulsant kwayoyi "valparin" Ya wadãtu a Pharmacy kawai a kan ganin likita. Su ya kamata a adana a cikin isar yara da kuma kariya daga danshi da kuma a zazzabi da ba fiye da 30 digiri.

A shiryayye rai da miyagun ƙwayoyi a karkashin shawara ne shekaru uku (daga ranar yi).

Medicament "valparin": analogues, ma'ana

Da miyagun ƙwayoyi a tambaya za a iya maye gurbinsu? Kamancin da analogues a cikin wannan kayan aiki, akwai da yawa. Wadannan sun hada da wadannan magunguna: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Kamar yadda shi ne yanayin da "valparin", wadannan kudi ya kamata a dauka kawai a kan likita ta umarni, a cikin shawarar dosages tsananin.

A ra'ayi na masu amfani da kuma kwararru

Abin da likitoci suka ce game da wannan magani, kamar "valparin"? Guest masana nuna cewa da miyagun ƙwayoyi ne sosai tasiri da ingantaccen, musamman a kowa yana da kuma m epilepsy.

Kamar yadda ga masu amfani da, yawancin su yarda da ra'ayin na likita. Marasa lafiya jayayya da cewa wannan karža yana nufin facilitates m ci gaba da kuma yada suppressing zumudi (farfadiya) da neurons. Duk da haka, ya kamata a lura da cewa yin amfani da wannan magani ne sau da yawa yana sa illa. A cewar abokin ciniki feedback, da aka fi faruwa m halayen su ne: fata alerji, tashin zuciya, anemia, da kuma nauyi riba. Idan ka fuskanci wadannan cututtuka kamata nan da nan a tuntuɓi likita.