Fibrinogen - kullum da kuma Pathology

A cikin nazarin da jini clotting tsarin, wannan index aka ƙaddara dole. Yana da muhimmanci ga yanayi daban-daban. Kafin aiki, a cikin shiri domin haihuwa, zuciya da jijiyoyin jini da kuma kumburi cututtuka na jini ko da yaushe ƙayyade fibrinogen. Norma ya ba da wannan ga manya da kuma jarirai. Ga mata masu ciki, na sama da iyaka ta yafi hakan. Amma mayar da hankali a kan matsayin kadan daga baya. Da farko, bari mu magana game da abin da shi ne kullum wakiltar fibrinogen.

Bisa ga sinadaran tsarin, shi ne - da gina jiki. Haka kuma an kira mafi clotting dalilai I. shi ne da hannu a cikin karshe mataki na jini clotting, wato - a cikin samuwar wani jini gudan jini. A wani m mutum fibrinogen a cikin jini ne ba a cikin narkar jihar.

A cikin hali na kunnawa da coagulation tsarin at ta mataki na farko a karkashin mataki na sauran clotting dalilai kafa thrombin.

A na biyu lokaci a ƙarƙashin rinjayar clotting fibrinogen da thrombin cleaved tuba zuwa insoluble fibrin, wanda Forms tushen wani jini gudan jini, wata thrombus. Ya unshi tsayawa zub da jini. Saboda haka ya bayyana ma'anar cewa jiki yana da zuwa fibrinogen. A kullum wannan abu don fara tasawa lafiya mutum yayi dace 2-4 g / l. A jariri jarirai, da kudi ne kasa - 1,25-3 g / l. Amma shi yakan a lokacin daukar ciki zuwa 6 g / l. Wannan shi ne m. Bayan duk, mace ta jiki shirya domin haihuwa, wanda ake dangantawa da yaushe zub da jini. Saboda haka, shi dai itace, da kudi na fibrinogen a cikin jini ne ba iri daya ba ga duk. shi ne mafi girma ga mata masu ciki.

"Eh, amma inda ba shi zo daga?" - da ka tambaye. Sai dai itace cewa wannan clotting factor da aka samar a cikin hanta da kuma sel da reticuloendothelial tsarin. Saboda haka, a cikin cututtuka na hanta, kamar hepatitis ko cirrhosis nauyi fibrinogen wanda kullum - ba kasa da 2 g / l, wani lokacin rage zuwa sosai kananan lambobi. Wannan zai iya haifar da wani iri-iri na zub da jini, zubar da jini a cikin fata da kuma mucous membranes. Shan wasu magungunan (androgens, anabolic steroids) iya rage matakin. A wasu lokuta, akwai inborn kurakurai na ilimi factor I. Wannan ake kira afibrinogenemia ko hypofibrinogenemia.

A kaifi rage na fibrinogen aka lura a karo na biyu da kuma na uku lokaci dessiminirovannogo intravascular coagulation ciwo. Wannan nauyi pathological yanayin, sau da yawa kawo karshen tare da copious hemorrhage saboda samuwar kananan tasoshin warwatse fibrin clots. Su ne sosai cewa fibrinogen depleting hannun jari. M fibrinolysis, kan aiwatar da ake dangantawa da tabbatarwa daga cikin rushe fibrin, kuma tare da wani karu daga fibrinogen. Yana rage-rage tare da kullum myeloid cutar sankarar bargo, tare da wani rashi na bitamin B12 a cikin jiki da kuma S.

A wasu cututtuka, a maimakon haka, akwai wani ƙara fibrinogen. Kullum most darajar coagulating factor ne daidai da 4 g / l. Amma rheumatic, cututtuka, mai kumburi tafiyar matakai, da ciwon daji, thrombosis da infarctions factor na matakin za a iya karu da 1.5-2.5 sau. Fibrinogen kuma ake kira m lokaci gina jiki, tun bayan da karuwa yana tare da m kumburi cuta. A matakin na wannan sunadari tare da raunin da ya faru, da yin amfani da baka hana kuma estrogen bayan tiyata.

Akwai shaida da cewa dagagge fibrinogen matakan iya riga bayyanar shanyewar jiki da kuma zuciya harin. mai bayyana dangantakar da ke tsakanin wadannan cututtuka da kuma ta gabata dagagge matakin da aka samu a gudanar da bincike.

Domin sanin matakin fibrinogen, dole ne ka wuce komai a ciki jini daga jannayẽnsa. A jini da aka dauka a cikin wani gwajin tube tare da anticoagulant.