Immunoglobulin E da kuma ta physiological muhimmancin

Immunoglobulin E da kuma ta physiological muhimmancin - al'amurran da suka shafi cewa bukatar shawara. A halin yanzu, akwai da dama iri immunoglobulins (antibodies). Akwai da dama iri antibodies cewa bambanta a cikin yanayin mataki da ginshikai na anti-infective rigakafi. Antibodies tsokane hazo da kuma flocculation na narkar da kwayan kayayyakin, agglomeration da agglutination corpuscular antigens (spirochetes, ƙwayoyin cuta, protozoa da kwayoyin). A jikin tantanin vibrios trypanosomes kuma gyarawa spirochetes immunoglobulins takamaiman gidaje tare da dace da, haddasa platelet adsorption. Yawanci, wadannan cututtuka jamiái suna riƙe a cikin lymphoid nama. A immunoglobulins na azuzuwan G kuma M tare da dace da zai iya hydrolyze spirochetes, trypanosomes, kwayoyin da ƙwayoyin cuta.

Effect na antibodies a kan pathogen da aka dakatar a lokacin da ta shiga cikin cell, kuma ba bayyana da antigen a kan salula surface. Immunoglobulins iya karfafa ko raunana rigakafi juriya da kwayoyin. Antigen-antibody hadaddun wanda yana dauke da antigen haddi, ya yi aikin da wani ya haramta motsa sakamako, kuma hadaddun tare da wani wuce haddi na antibodies sa kishiyar sakamako. Mafi sau da yawa, da immunoglobulins ne hanyar autoimmune da kuma rashin lafiyan rikitarwa.

Ige da aka hada yafi a cikin sel da mucous membranes na numfashi, gastro-na hanji fili, kazalika a yankin Lymph nodes. A karo na farko, a matsayin mai raba aji na immunoglobulin E aka gano a cikin 1966, da kuma a 1968, da WHO ya gane kamar yadda m Ige aji na immunoglobulins.

wannan aji na sunadaran samu a cikin mutane, mannyan birai da kuma wasu gwaje-gwaje dabbobi. Mafi yawa daga cikin E immunoglobulin kwayoyin nasaba da fata mast Kwayoyin da basophils. Tun a karkashin al'ada yanayi immunoglobulin E yawa a cikin jini magani na 'yan nanograms da milliliter, da ainihin ra'ayin tsarin wannan kwayoyin da aka samu kawai a kan tushen da nazari da dama myeloid sunadaran. Very low matakan immunoglobulin E a magani a fili ya taso ne daga cewa shi ne iya "janyo" ya tabbata daga cikin Kwayoyin kuma da tabbaci kisa ga mast Kwayoyin da basophils.

An yi imani da cewa Іg E ne manyan aji na immunoglobulins wanda nuna mast Kwayoyin da basophils su shiga a rashin lafiyan halayen. A matakin na wannan furotin a magani na marasa lafiya da alerji ƙaruwa kuma yawanci ya wuce 350-800 U / MG. Total Ige ta kullum a cikin yara kasa da shekaru 12 watanni har zuwa 15 U / ml. Ige taka muhimmiyar rawa a cikin halayen da nan da nan hypersensitivity. Immunoglobulin E kullum a manya Range daga 0 zuwa 120 U / ml.

Kamar yadda zamani Concepts, babban aiki na immunoglobulin E ne don kare jiki ta mucous membranes saboda da kunnawa da gida dalilai na jini jini da kuma effector Kwayoyin. Pathogens ne iya karya ta kariya line cewa dokoki immunoglobulins na aji A. Bayan da ƙwayoyin cuta, ko kwayoyin cuta a farfajiya na mast Kwayoyin kisa ga takamaiman immunoglobulin E aji, a sakamakon irin wannan hulda mast Kwayoyin sami wata sigina don saki daga vasoactive amines da chemotactic dalilai, wanda a nuna haddasawa inflow na zagawa da IG aji da G, najumla, eosinophils da neutrophils. Eosinophilic chemotactic factor, wanda aka saki daga mast Kwayoyin, da inganta harkokin jari na eosinophils da kuma halakar da tsutsotsi. An yi imani da cewa Ige adsorbed a farfajiya na m, janyo hankalin macrophages godiya ga Fc-rabe.