Lyophilisate - abin da yake da shi? Valium for injections. Yadda za a yi kiwo lyophilizate?

A ci gaba da Pharmaceutical masana'antu ya kai ga bukatar ci gaba da kwayoyi da cewa zai iya zama a karkashin daban-daban na waje yanayi a kiyaye da magani Properties. Alal misali, shirye-shirye dangane da aiki sinadaran. Yadda amfani kwayoyin da aka adana a cikin irin shirye-shirye? Storage ne saboda da m Hanyar bushewa nazarin halittu aka gyara daga cikin miyagun ƙwayoyi. Wannan hanya ake kira da lyophilization, da kuma abu da kanta, don haka bi da, da ake kira "lyophilisate". Mene ne shi, a cikin abin da miyagun ƙwayoyi da ake amfani, wanda yana da sakamako - za ka iya koyi da karanta wannan labarin.

Mene ne daskare-bushewa?

Lalle ne m nasara a cikin Pharmaceutical masana'antu ya da sabuwar dabara na da hanyar da daskare-bushewa. Fassara daga Girkanci kalmar ma'ana "ta soke", "bushe". A Hanyar kunshi a cikin dehydration na wani likita abu da daskarewa da kuma kara injin bushewa Hanyar. A abũbuwan amfãni daga wannan hanya na shirye-shiryen da aka gyara domin likita shirye-shirye ne:

• Kadan kwashe physico-sinadaran magani na nazarin halittu abu, da cewa ba a kiyaye ingancin amfani abubuwa.
• a lokacin lyophilization auku kadan canji a cikin tsarin da siffar da fara abu.
• shiryayye rai da miyagun ƙwayoyi ne ƙara muhimmanci.
• Extended ajiya yanayi, kamar high yanayin zafi ko high zafi.

Daga cikin tarihi na daskare-bushewa Hanyar

Ƙirƙira gwada da kwanan nan lyophilisate. Mene ne shi, likita masana sun koya a karon farko a 1909. A sa'an nan da masana kimiyya ne na farko da bushe a cikin wannan hanya da ciwon hauka cutar. A kadan daga baya kora preform busassun jini jini da lyophilization. A daidai wannan lokacin, Rasha masana kimiyya sun ɓullo da na farko na'urar for sublimation, sa'an nan daskare-bushewa da aka yadu ɓullo da kuma rarraba. Wannan hanya ya zama don samar da wani babban kewayon likita kwayoyi: jini jini, kwayan jamiái, hormones, maganin rigakafi da sauransu.

Aiki injin daskare bushewa

Irin wannan hanyar shirye-shiryen da aka gyara shi ne ya fi kowa a cikin Pharmaceutical masana'antu. Kamar yadda wannan hanyar lyophilisate, abin da shi ne da kuma inda wannan hanya da ake amfani? Tare da irin wannan hanyar bushewa samar da dama magunguna. Amma baya ga wannan, da hanyar amfani a cikin sinadaran da abinci masana'antu. Sanya lyophilizates riƙe amfani Properties, ba ya bukatar stringent ajiya yanayi, da ƙara shiryayye rayuwa, su ne kamar hadari a matsayin yiwu ga masu amfani da.

Na'urorin ga lyophilization

Mun ɓullo da wani musamman na'ura don a samar da lyophilisate. da yin amfani da irin wannan na'urorin ya umurci na bukatar wani musamman fasaha ilmi da basira. Tabbatar da tsarin for lyophilization na Faransa samar da "Yuzifrua" German "Hohvakumm" English "Edward," American "nutse". A Rasha, ya fi na kowa na'urar ne a Czech-yi "Frigerio".

A ra'ayi na kwayan lysates

Domin samar da immunostimulatory, antiviral kwayoyi lyophilizate amfani kwayan lysates. Bari mu ga abin da a zahiri tsaye ga wani hadadden likita terminology. Da farko kana bukatar ka gane abin da na kwayan lysates. Wannan bai zama ba fãce da kwayoyin microscopic barbashi kafa ta inji, sunadarai ko thermal effects. Kuma, daidai da, suka zama lyophilizates a musamman bushewa tsari.

Amfani na kwayan lysates

Bushe da lyophilization lysates na kwayoyin amfani da immunostimulants. Ginshikai na mataki ne kama da sakamako na maganin. Da zarar a cikin jiki, da cutar sa martani na mutum rigakafi da tsarin da samar da m antibodies. Saboda haka, idan akwai kara kamuwa da mutum pathogen rigakafi da tsarin zai amsa quite daban fiye farko kamuwa da cuta. A gaban a jikin m antibodies, wanda ci gaba a sakamakon da cewa mutumin ya ɗauki wani m gwargwado lyophilisate kwayoyin zai rage samu damar kamuwa da cuta, ko tsanani da rashin lafiya. A mafi yawan irin kwayoyi via numfashi kwashe prophylaxis na kwayar cututtuka.

Da yin amfani da daskare-bushe fom

Magunguna - lyophilisates suna samuwa a cikin siffofin daban-daban, kamar yadda emulsions, bayani da kuma bushe foda. Alal misali, da miyagun ƙwayoyi "Bifidumbacterin" - lyophilisate a cikin wani nau'i na bushe foda, wanda ya bukatar dilution kafin amfani. Dama sashi da kuma hanya da gwamnati na iya sanya likita.

A bayani da aka daskare-bushe injectable

Sau da yawa lyophilisates amfani ga allura. Domin intramuscular da kuma igiyar jini miyagun ƙwayoyi dole shirya wani likita bayani. Yana da kyau idan irin wannan hanya ne da za'ayi gwani, kamar yadda muhimmiyar to a fili tsayar da rabbai abubuwa da kiwo da fasaha. In ba haka ba, za ka iya ba kawai lalata miyagun ƙwayoyi (saboda ba daidai ba dangane iya faruwa irin wannan sinadaran halayen kamar yadda hadawan abu da iskar shaka), amma kuma cutar da lafiya da haƙuri. Kowane miyagun ƙwayoyi dilution yana da halaye da kuma aikace-aikace.

Alal misali, injections suna ba da kwayoyi kamar "Longidaza", "hondrolon". Yadda za a shuka a lyophilisate yi nufi ga allura? La'akari da hanyar da yin amfani da wani magani da misali "Vfend" antifungal wakili. Wannan magani ne a bushe foda, cushe a bakararre kwalabe. Production bayani ga allura ne da za'ayi a 2 matakai: kai tsaye rushe, sa'an nan da samu tattara dilution abu. A vial shiri da za a narkar da a 20 ml na kawota sauran ƙarfi. Sa'an nan da ake so adadin daya-lokaci miyagun ƙwayoyi tattara aka diluted da sodium chloride ko glucose bayani.

Immunomodulating miyagun ƙwayoyi "Polioksidoniy"

"Polioksidoniy" - shi ne wani misali da wani magani da aka yi amfani a cikin nau'i na intramuscular ko igiyar jini allura. Da miyagun ƙwayoyi - lyophilisate. Umurnai na ta yin amfani da nuna cewa ya aka nada a matsayin yara daga 6 watanni da kuma manya a rikitarwa kwayar numfashi da ciwon ya kama, ko ga manufar yin rigakafi.

A sashi daga cikin miyagun ƙwayoyi An wajabta ta halartar likita shan la'akari da yawa dalilai. Domin yi na intramuscular bayani 6 MG na lyophilizate an narkar da a 2 ml na sodium chloride. A bukatar igiyar jini allura na 3 ml na sauran ƙarfi, kuma da tattara aka diluted da 200 ml gemodeza ko dextrose bayani.

"Polioksidoniy lyophilisate" iya tsokane wani rashin lafiyan dauki, kuma ba jituwa tare da wasu sauran kwayoyi, don haka kafin yin amfani da shawarci likitan ka da kuma karanta umarnin a hankali.

Drug "Bifidumbacterin lyophilisate": umarnin don amfani da

Magani "Bifidumbacterin" - a lyophilisate na live kwayoyin. Samuwa a cikin wani nau'i na bushe foda ga shiri na baka mafita.

Ana amfani da su mayar da hanji microflora, misali bayan shafe tsawon kwayoyin magani ko a cikin shimfiɗar jariri dysbacteriosis. An nuna ga cututtuka irin su:

• hanji cututtuka.
• Na ciki da kuma duodenal ulcers.
• pancreatitis.
• dalma da sauran cuta na narkewa kamar tsarin.

Kuma amfani da topically "Bifidumbacterin lyophilisate". Umurnai na amfani nuna cewa festering raunuka iya gabatar applique sanya daga wani gauze soaked a cikin wani bayani halitta.

Intravaginal amfani a take hakkin da farji microflora, rectally a cikin postoperative zamani.

Da miyagun ƙwayoyi An wajabta, ko jarirai, za a iya amfani da shi da kuma lactating uwãyensu ne. A lokacin daukar ciki, kafin yin amfani da magani kamata shawarci likitan.

Foda shiri da aka narkar a wani karamin adadin dumi ruwa: nono madara, kiwo kayayyakin, juices, Boiled ruwa. A sashi dogara a kan haƙuri ta shekaru da cutar.

Yana da muhimmanci a tuna cewa ba za ka iya gina "Bifidumbacterin" a wani zafi ruwa, dauka a layi daya tare da antibacterial kwayoyi, kazalika don adana da diluted foda.

Lyophilisate "Interferon"

Medicament Rasha yi "Interferon lyophilisate" zo a foda siffan, kunsasshen cikin vials. The aka gyara kunshe a shi - shi ne halitta alpha interferon da jini leukocytes. "Interferon" shi ne wani antiviral wakili, da kuma qara jiki ta jure daban-daban iri iri na kamuwa da cuta.

Nasally amfani da miyagun ƙwayoyi, watau. E. shuka ko fesa ta musamman da na'urorin a cikin hanci Tsarki. Domin gudanar da wannan hanya, ku farko da bukatar soke da lyophilisate. A saboda wannan dalili, bayyana a vial kuma an kara wani dumi distilled ruwa har sai da aka zaɓa matakin na 2 ml. Sa'an nan kuma ya zama dole domin ya girgiza vial ta soke da bushe barbashi.

Magani shuka a cikin hanci 5 saukad da sau daya a rana, ko inhalation hanya yi amfani da musamman apparatuses.

A wani taron bai kamata a gudanar intravenously ko intramuscularly da kuma baki wannan lyophilisate! Umarnin da miyagun ƙwayoyi ambaci kawai hanci Hanyar yin amfani.

Da sabuwar dabara ne daskare-bushe kayayyakin da gudummawar da zargin da yawa zamani pharmaceutical kwayoyi. Wannan nau'i na miyagun ƙwayoyi saki muhimmanci rage kudin kuma qara shiryayye rayuwa, da kuma aikace-aikace ba ya haifar da da yawa wahala ko a gida. Amma, kamar wani magani, da shi na bukatar kafin shawara da wani gwani miyagun ƙwayoyi-lyophilisate. Mene ne shi, a cikin abin da lokuta ya zama dole a yi maka wannan miyagun ƙwayoyi, jujjũya, a cikin kawai likita.