Macroprolactinum - mece ce? Macroprolactin gwaji: al'ada da kuma hauka

Prolactin (luteotropic) ana kiransa hormone wanda kwayoyin adenohypophysis suka samar. Abun yana da siffofi daban-daban, a cikin nau'i ne a jikin mutum. Daya daga cikin wadannan siffofin luteotropic hormone shine macro-prolactin. Mene ne, menene ayyukan da kaddarorinsa, zamu duba gaba.

Batu na asali na prolactin

Hakanan hormone ya ƙunshi sunadaran prolactin kamar sunadaran peptide. Dukiyarta ta dogara ne akan sa hannu a cikin matakai na haifuwa, kuma gabobin da ake nufi da aikin su ne gland.

An sami masu karɓar maganin prolactin a wasu sassa na jiki, amma har yanzu basu da tabbacin yadda suke amsawa akan sakamakon abubuwan hormonal. Ana samun masu karɓa na jin dadi a cikin wadannan sassan:

• Gudun;
• Kwana;
• Thymus;
• Zuciya;
• Pancreas;
• Koda;
• Uterus da ovaries;
• Skin integument.

Hakanan yana cikin kwayar mutum a cikin nau'i uku: 85% na abu yana da nau'i na monomer, 10% - nau'i na dimer kuma kawai 5% suna cikin macroprolactin.

Ayyuka Prolactin

Babban "aikin" na hormone shi ne ya kara da kuma kula da yawan kayan samar da madara a yayin yaduwar jaririn. A ciki, wani isasshen matakin na prolactin kula da jima'i hormone estrogen. Bayan haihuwar jaririn, adadin isrogens yana raguwa sosai.

A wannan lokacin, ci gaba da prolactin yana taimakawa ta hanyar motsawa daga masu sarrafa kwayoyin halitta. Yarin da jaririyar nono yana aiki da yaduwar oxytocin, wanda ke taimakawa wajen rarraba madara. Wato, prolactin yana ƙarfafa samar da madara da jari a cikin ƙirjin, amma oxytocin yana da alhakin aiwatar da raunin madara.

Ayyukan prolactin yayin daukar ciki za a iya gani a kan jariri. Babban abun ciki na hormone ya bar wani burin akan jariri. Bayan 'yan kwanaki bayan haihuwar jariri, jaririn zai iya kasancewa, wanda ba ya buƙatar karin kari kuma zai wuce a cikin makon farko na rayuwa.

Sauran kaddarorin na hormone luteotropic:

• Tsarin maganin kwayar halitta;
• Tsayar da tsawon wanzuwar jiki na jiki;
• Yin rigakafin sabon ciki;
• A kananan sakamako analgesic;
• Kasancewa wajen samuwar tayar da hankali;
• Tabbatar da rashin haƙuri na amfrayo;
• Kasancewa wajen samar da kayan inganci.

Hanyar aikin cigaba

A cikin jikin mutum mai lafiya da mace mai ciki wadda ba ta da matsalolin kiwon lafiyar, kwayoyin kwayoyin halitta suna hana samar da prolactin. An hada cikin hypothalamus. Tare da duk wani yanayin ilimin halitta, akwai rushewa a cikin dangantaka tsakanin pituitary da hypothalamus, sakamakon sakamakon da adenohypophysis kwayoyin ke haifar da hormone luteotropic kuma matakin ya ƙaru a magani.

Macroprolactinum - mece ce?

Wannan nau'i ne na prolactin, wanda yana da nauyi mai nauyi. Ya wanzu a cikin jiki a kananan ƙananan. Mahimmancin nau'i shine jigon kayan aiki na hormonal tare da immunoglobulin.

Prolactin da macroprolactin a cikin adadin da ya dace da al'ada ya kamata a kasance a cikin jiki na mace mai ciki da mace. Duk sauran lokuta ana daukar su a matsayin pathological.

Macroprolactin, wanda yana da kwayar halitta mafi girma, yana da muhimmiyar haɗuwa cikin jiki. Sauran siffofin luteotropic hormone ana samun sauri saboda nauyin kwayoyin ƙananan.

Macroprolactin, wanda al'ada za a yi la'akari da shi, yana da ɗan aikin nazarin halittu, wanda ke nufin cewa kwayar halitta ba zata iya amsawa da canje-canje a cikin filayensa ba. Hotuna na asibiti an nuna ko kuskure tare da haɗari na haɗuwa, wanda ba alamar ƙirar ba.

Haka kuma namiji ya hada wannan hormone. Yana da alhakin samar da spermatozoa, ayyukansu da kuma kira na testosterone. A cikin maza, filayen macroprolactin sun fi ƙasa da mata.

Ana yin nazari don nazarin matakan hormone, da halayen samfurori da mahimmanci a cikin yanayin jima'i na rashin haihuwa tare da dalilai na bincike.

Hypermaproperactinemia

Idan an ɗauke macroprolactin, to wannan yanayin ana kiransa hypermacroprolactinemia. Wannan farfadowa ba abu ne mai tayar da hankali ba wajen cigaban ƙananan ƙirji da osteoporosis idan aka kwatanta da jihar karuwar adadin ƙwayar prolactin.

Ya kamata a tuna cewa tashe-tashen hankula a matakin hormone a cikin rikice-rikicen ya nuna matsala cikin aikin hypothalamic-pituitary system. Kasancewa da babban adadin macroprolactin zai iya bayyana kanta a cikin hanyar dysmenorrhea, kuma wani lokaci ma yana haifar da rashin haihuwa.

Prolactinoma

Kalmar "prolactinoma" tana nufin bazuwar ilmin gajiyar jiki, wanda wani nau'i ne na samar da hormone luteotropic. Adenomas zai iya faruwa a cikin mata da maza. Ba'a riga an tayar da ilimin halitta na bayyanar prolactinoma ba. Akwai ra'ayoyin game da farfadowa da illa, da kuma cewa ciwace-ciwacen sun bayyana a cikin layi daya tare da maganin cututtuka na sauran sassan jikin endocrine.

Rubuta nau'i biyu na ciwace-ciwacen ƙwayoyi ta wurin girman su da wuri:

• intrasellyarnye ba ya mika bayan da sella turcica , kuma suna da wani diamita na kasa da 10 mm.
• Extrasellar ya wuce bayan turken Turkiyya kuma yana da diamita fiye da 10 mm.

Bugu da ƙari, babban ciwo da bayyanar da ake ciki, wanda masana kimiyya suka tsara maganin bincike don prolactin da macroprolactin, akwai wasu alamun asibiti na cutar:

• Gudun hanyoyi masu kyan gani;
• Rage sharhi a cikin kullun gani;
• Bifurcation a idanun;
• Rashin iyawa don amfani da hangen nesa;
• Ciwon kai;
• Dama;
• Raguwa da irritability;
• A lokuta masu tsanani, cikakke makanta.

Bugu da ƙari, tantancewar gwajin gwagwarmaya, CT da MRI na kwakwalwa, ƙarfafawa (hormonal) da kuma zane-zane (kima na amfani da kasusuwan amfani da bambancin) ana amfani da su don tabbatar da asali.

Yanayin Hanya

Analysis a kan makroprolaktin - abin da yake da shi? Wannan bincike Hanyar immunohemilyuminestsentnoy dauki, wadda aka wajabta shi a kan dukan marasa lafiya da daukaka matakan prolactin a cikin jiki.

Analysis yana daya daga cikin hanyoyi masu ban sha'awa. Lokacin da aka gudanar, kwayoyin hormone suna "zamawa" ta ƙananan kwakwalwa, wanda, idan an ɗaure su zuwa prolactin, haskaka wuraren a ƙarƙashin aikin radiation ultraviolet. Girman luminescence an auna shi ta hanyar hasken rana - na'urorin ƙwaƙwalwa na musamman.

Ana nuna ƙididdiga masu yawa na macroprolactin tare da taimakon polyethylene glycol. Suna gudanar da haɗuwa da ƙwayoyin rigakafi. Idan bayan aiwatar a cikin magani aka ƙaddara kasa da 40% na jimlar luteotrophic hormone matakin, wannan shaida ce ta cewa wani gagarumin yawan da diddigin abu makroprolaktina.

Indiya ga ganewar asali

Akwai wasu yanayi wanda masana kimiyya ke ba da ma'anar ƙididdigar ilimin lissafi da ƙimar lissafi na prolactin da siffofinsa. Ana gudanar da bincike don macroprolactin a cikin lokuta masu zuwa:

• Tsari - pathological mugunta na madara ko colostrum;
• Kasancewar prolactin - ciwon daji na adenohypophysis wanda ya hada da nauyin abu mai yawa;
• Tsarin lalacewar hangen nesa;
• Rashin amfani;
• Rashin haila daga sama da watanni shida;
• Hanyoyin ciwon daji na ilimin ilimin ilimin unxplained;
• Nazarin ilmin lissafi na gurasar gizon gwal;
• Kwanan lokaci babu watsi da kwayar halitta;
• Osteoporosis;
• Mastopathy;
• Binciken tasirin prolactin farfadowa.

Tsarin al'ada a lokuta daban-daban

Adadin prolactin mai ganowa (sakamakon μME / ml):

• Tsarin namiji - 44,5-375;
• Tsarin mace shine 59-619;
• Postmenopause - 38-430;
• Nuna yaron - 205,5-4420.

Sakamakon ganowar macroprolactin an fassara shi a cikin waɗannan bambance-bambancen:

• Kyakkyawan macroprolactin;
• Macruprolactin ba a gano ba;
• Kyakkyawan macroprolactin yana cikin shakka.

Kyakkyawan sakamako

Hypermaproperactinemia an ƙayyade game da bayanan wadannan pathologies:

• Neoplasm na hypothalamus;
• Tsarin Tumor na farfadowa na pituitary;
• Pathology na thyroid gland shine (rage a cikin hormonal mugunya);
• Polycystic ovary;
• Kuna gaza;
• Tashin cutar;
• anomalies adrenal gland shine yake, adrenal insufficiency .
• Tsarin lupus erythematosus;
• Arthritis na irin rheumatoid;
• Hypovitaminosis na pyridoxine.

Babban mahimmancin yawan macroprolactin na nufin cewa mai haƙuri zai iya daukar shan magani na dogon lokaci.

Tsarin hormonal yana shafar:

• Antihistamines;
• Antipsychotics;
• Diuretics;
• Magungunan antihypertensive;
• Antipsychotic kwayoyi;
• Magungunan maganganu;
• Antidepressants;
• Ƙarkewar ƙwayoyin cuta a cikin ɗumbin yawa da kuma amfani da tsawo.

Raguwar dabi'u

Tare da wasu jihohi na macro-prolactin, nauyin abin a cikin mata ya bambanta dangane da lokacin rayuwa, yana iya zama ƙasa da ƙirar mafi kyau. Wannan sakamako yana da mahimmanci ga shari'ar da ke faruwa:

• Rashin fatar haɗari wanda yake tasowa a kan asalin jinin jini yayin aiki;
• Tashin ciki (fiye da makonni 41-42);
• Amfani da kwayoyi don dogon lokaci don magance fukaci, Calcitonin, hormones, Morphine, Rifampicin, Nifedipine.

Wane ne ya nada nazarin kuma a ina ya kamata a ba shi?

Ƙwararrun kwararrun kwararru na iya jagorantar binciken: masanin ilimin lissafi, likitancin jini ko endocrinologist. Ana gudanar da bincike a ɗakin gwaje-gwaje na dakunan shan magani na musamman ko cibiyoyin tsara iyali. Ana buƙatar jini mai baƙo don ganewar asali.

Domin sakamakon ya zama daidai, dole ne mai yin haƙuri ya shirya don nazarin macro-prolactin:

1. 12 hours kafin canjin, ba da abinci.
2. Kwanaki da yawa kafin shigarwa, kada ku yi amfani da kwayoyi bisa isrogen da androgens. Dole ne likita wanda ya ba da zartarwa ya sanar da mai haƙuri game da shi.
3. Don 24 hours gaba daya dakatar da shan magunguna.
4. Domin kwanaki da yawa kafin bincike, cire duk wani aiki na jiki kuma ku guje wa yanayi na damuwa.
5. A ranar gwajin, dole ne ka daina shan taba.

Kammalawa

Daya daga cikin siffofin luteotropic hormone shine macroprolactin. Mece ce, menene siffofin duba takardun shaida da ma'auni - muhimman bayanai ga kowane ma'aurata waɗanda ke so su kasance iyayensu na gaba ko kuma suna aiwatar da shirin tsarawa.