Monocytic ehrlichiosis mutum: bincike da kuma magance

Monocytic ehrlichiosis mutum - wannan shi ne wani m cutar lalacewa ta hanyar kwayoyin cuta na iyali Ehrlich. Pathology iya tabbatar da wani kaifi karuwa a jikin zazzabi, ciwon kai, tsoka zafi (myalgia), jin sanyi, unexplained gajiya, wani rauni. Symptomatology aka lura a 'yan makonni bayan da farko kamuwa da cuta. Bugu da ƙari kuma, a lokuta da dama, a sakamakon awon gwaje-gwaje saukar raguwa a yawan platelets a zagawa da jini (thrombocytopenia) tare da wani karu a farin jini cell count (leucopenia), da kuma wani mahaukaci karuwa a matakan da wasu hanta enzymes (hanta transaminase). A wasu lokuta, cututtuka ci gaba da aka bayyana, a tashin zuciya, amai, zawo, nauyi asara, asarar fuskantarwa a sarari. Idan haƙuri aka gano mutum monocytic ehrlichiosis, magani ya kamata bi nan da nan bayan ganewar asali, saboda babu wani isasshen far cutar take kaiwa zuwa m rikitarwa kamar na koda ko numfashi gazawar. Dako na cututtuka ne mites.

Da ãyõyinMu, kuma cututtuka

Monocytic ehrlichiosis mutum, bayyanar cututtuka na wanda shi ne mai sauki da za a rikita batun tare da bayyanar cututtuka na sauran cututtuka, kuma aka samu comparatively kwanan bincika. Yawanci, da Pathology bayyana kamar makonni uku bayan da wani kaska cizo - Ehrlich m iyali kwayoyin. Da farko, marasa lafiya fama da hankula ãyõyin kamuwa da cuta, ciki har da wani kaifi karuwa a jiki zafin jiki da kuma janar rauni. A wasu lokuta, fata na gaggawa da aka kara wa wannan bayyanar cututtuka. A tsanani cututtuka da haƙuri hasarar ci, rasa nauyi da sauri da kuma shi ne a hadarin kamuwa da cutar anorexia. Wani lokaci, akwai kuma alamun ehrlichiosis rarer - kamar tari, zawo, ciwon makogwaro (pharyngitis), da kuma ciwon mara.

A mafi yawan lokuta, a lokacin da mutum monocytic ehrlichiosis ana zargin da bincike da ya shafi jini gwaje-gwaje. A sakamakon wadannan Nazarin (hade leuko- da thrombocytopenia bi-biye da wani mahaukaci tadawa na hanta enzymes) da damar da mãsu haƙuri a saka daidai ganewar asali. A wasu lokuta, da mãsu haƙuri kuma shan wahala daga hanta kumburi (hepatitis).

A rashin isasshen magani ci gaba mai tsanani monocytic ehrlichiosis mutum. Bayyanar cututtuka da cutar a wannan mataki bambanta daga tuta bayyananen kamuwa da cuta da za a iya bayyana a cikin wadannan mamaki da kuma cewa:

• shortness na numfashi (dyspnea, dyspnea).
• matsaloli tare da jini clotting (coagulopathy) cewa zai iya kai wa ga zub da jini a cikin gastrointestinal fili.
• neurological cuta saboda cerebral da kuma kashin baya kamuwa da cuta (tsakiya m tsarin).

Idan da kamuwa da cuta share tsakiya m tsarin, a haƙuri da ganewar asali "mutum monocytic ehrlichiosis" gano mahaukaci nama (ƙari) a cikin kwakwalwa. Bugu da kari, a wasu lokuta ɓullo da meningitis - kumburi da m membrane membranes na kwakwalwa da kuma laka. Cerebrospinal ruwa ƙila za a shafa da kamuwa da cuta.

neurological bayyananen

Neurological bayyanar cututtuka da cutar sun hada da:

• disorientation.
• mahaukaci ji na ƙwarai zuwa ga haske (photophobia).
• stiffness a cikin wuyansa.
• aukuwa daga uncontrolled lantarki aiki a kwakwalwa (seizures).
• coma.
• A rare lokuta, akwai:
• ɓarna, m reflex halayen (hyperreflexia).
• incoordination na son rai ƙungiyoyi (ataxia).
• m asarar motor damar iya yin komai na gyara man fuska tsokoki saboda lalacewar na daya (ko fiye) na goma sha biyu nau'i-nau'i daga jijiyoyi hade da kwakwalwa (girman kwanyar jijiya palsies).

Monocytic ehrlichiosis da mutum granulocytic anaplasmosis in babu sana'a magani daga cututtuka ne rai barazana.

dalilai

Duk irin na bincikar Pathology lalacewa ta hanyar kwayoyin cuta na ga iyali na Ehrlich. Pathogen monocytic ehrlichiosis mutum yana dauke da gram-korau.

An yi imani da cewa babban dalilin kamuwa da cuta - kaska cizo. Wasu daga wadannan kwari ne dako na pathogens.

Da zarar a cikin jiki ta hanyar da jini, Ehrlichia propagate ta hanyar da jini da lymphatic tasoshin. Lymph - a jiki ruwa dauke da Kwayoyin tsara don yaki da cututtuka. A kwayoyin dauka zama a wasu sel (monocytes da macrophages), wanda wasa invaluable rawa a rike da wani barga aiki na rigakafi da tsarin. Wadannan Kwayoyin mamaye kwayoyin da kuma sarrafa (aiwatar kira phagocytosis), ciki har da kwayoyin cuta da kuma wasu kasashen waje abubuwa. Duk da haka, Ehrlichia shiga zurfi a cikin halitta rigakafi tsaro fara girma a cikin vacuoles - cavities, kewaye da wani membrane. Haka kuma cutar rinjayar ba kawai monocytes da macrophages a cikin jini, amma kuma wasu iri na jiki kyallen takarda (ciki har da bargo, Lymph nodes, hanta, saifa, kodan, huhu da kuma kashin baya ruwa).

Differentsiatsialnaya ganewar asali: granulocytic anaplasmosis

A bayyanar cututtuka na wannan kamuwa da cuta za a iya sauƙi rikita batun tare da bayyanar cututtuka na sauran pathologies. A mafi m bambanci ganewar asali zama monocytic ehrlichiosis da mutum granulocytic anaplasmosis.

Ba kamar Mach, granulocytic anaplasmosis lalacewa ta hanyar kwayoyin da ya dace sunan Anaplasma. Kananan kwayoyin ɗauke da ticks, rinjayar wasu granular farin jini Kwayoyin - neutrophilic granulocytes. Wadannan Kwayoyin suna da hannu a aiwatar da phagocytosis kuma yawanci alhakin halakar cutarwa microbes. Lokacin kamu da Anaplasma hankula cututtuka yawanci bayyana a cikin mako guda bayan da kaska cizo - transporter kwayoyin. Kusan ko da yaushe, da mãsu haƙuri shan wahala daga zazzabi, jin sanyi, tsoka zafi (myalgia), janar wani rauni, gajiya, ciwon kai. Wani lokaci akwai kuma wani tari, amai, da / ko disorientation. Bugu da ƙari kuma, granulocytic anaplasmosis kama da kamuwa da cuta kamar mutum monocytic ehrlichiosis, da cewa sakamakon da jini gwaje-gwaje saukar da wannan karuwa da wasu hanta enzymes (hanta transaminase). Sau da yawa undiagnosed da anemia lalacewa ta hanyar wani mahaukaci karu a matakin na ja da maikacin jini a cikin zagawa da jini. A rashin dace magani auku a hadarin tasowa na koda gazawar. A Amurka, lokuta da mutum granulocytic anaplasmosis mafi akai-akai rubuta a arewa maso gabashin da kuma yammacinta.

zazzabi sennetsu

Monocytic ehrlichiosis mutum (Mach) da za a bambanta kuma daga zazzabi sennetsu - musamman talauci da aka sani da sosai m cutar na da subtype na mutum ehrlichiosis lalacewa ta hanyar kwayoyin cuta da kuma ayi kasafi mai suna - Ehrlichia sennetsu. A 'yan makonni bayan da farko kamuwa ci gaba da bayyanar cututtuka kama da na kowa ãyõyin Mach: kaifi karuwa a jikin zazzabi, ciwon kai, tsoka zafi (myalgia). Wasu marasa lafiya da tashin zuciya, amai ko asarar ci har anorexia. Bugu da ƙari, sakamakon jini gwaje-gwaje za a iya gani a rage matakin na farin jini cell count (leucopenia) da kuma pathological karuwa a juz'i na hanta enzymes. The m (ko m) sennetsu zazzabin har yanzu ba a daidai kafa. wasu masana kimiyya bayar da shawarar cewa zai iya zama da ticks, alhãli kuwa wasu masu bincike suka ce cewa wannan cuta na iya zama kamuwa bayan cin raw kifi. A lokacin, cututtuka aka lura kawai a gabashin Japan da Malaysia.

Lyme borreliosis

Lyme borreliosis - wani cutar da lalacewa ta hanyar kwayoyin cuta, spirochetes na Borrelia iyali. Dako vredosnosnyh microbes ne Ixodes scapularis. A mafi yawan lokuta, cutar ne da farko bayyana bayyanar da wani ja kumburi a fatar, wanda a farko ya yi kama da tashe madauwari tabo na kananan size (papules). Papule fara girma cikin sauri da kuma ƙarshe kai a kalla biyar santimita a diamita. Bayan da cewa akwai symptomatology, characterizing da monocytic ehrlichiosis mutum. Yiwuwar kamuwa da cuta daga Lyme borreliosis ne sosai fiye da ƙananan hadarin kamawa Mach, amma bambanci ganewar asali da ya rage wani zama dole mataki a kayyade da kamuwa da cuta. Marasa lafiya da Lyme borreliosis ma sau da yawa koka da zazzabi (ba kamar yadda kaifi da kuma kawo hadari, kamar yadda a Mach), jin sanyi, myalgia, ciwon kai, wani rauni, gajiya, kuma zafi ko stiffness a cikin manyan gidajen abinci (dauke da kwayar cutar amosanin gabbai), yawanci a cikin gurfãne. A symptomatology iya daukar nau'i na maimaita hawan keke. A tsanani lokuta, idan ya bar untreated lura neurological cuta da kuma cututtuka na zuciya tsoka. Bisa kididdigar da, mafi yawansu Lyme borreliosis da aka samu a arewa maso gabashin Amurka. Duk da haka, akwai lokuta na kamuwa da cuta da kuma a wasu kasashe, ciki har da kasar Sin, Japan, Australia da kuma wasu kasashen Turai.

piroplasmosis mutum

Monocytic ehrlichiosis mutum, damar kamuwa da cuta wadda ne in mun gwada fi hadarin kamuwa da cuta da sauran kwayoyin cuta, ba kawai yiwuwar hatsari cutar ɗauke da ticks. Piroplasmosis mutum (a cikin wasu sharuddan - babesiosis) - kamuwa da cuta lalacewa ta hanyar guda-celled micro-kwayoyin daga gidan Babesia. Mafi sau da yawa wannan cuta rinjayar dabbobi, amma lokaci-lokaci akwai lokuta na mutanen da suka kamu da ita. A musamman, an yi imani da cewa ticks ne dako na Babesia cewa zai iya parasitize jikin mutum. Piroplasmosis kamar monocytic ehrlichiosis mutum na farko da bayyanar cututtuka: marasa lafiya koka da zazzabi, jin sanyi, ciwon kai da kuma tsoka zafi, tashin zuciya da amai. Bugu da ƙari, akwai irin wannan nadiran mamaki kamar wanda bai kai halakar ja Kwayoyin a cikin jini zagayawa (hemolytic anemia), mahaukaci karu a su lambobi (thrombocytopenia), rage a total farin jini cell count (leucopenia), da kuma kara girma daga cikin baƙin ciki (splenomegaly). Mutane da na kowa m kiwon lafiya cututtuka na iya bambanta softness ko ba ya nan gaba ɗaya. Mai tsanani lokuta na piroplasmosis mutum lura a marasa lafiya wanda a baya tiyata don cire baƙin ciki (splenectomy) ko da wani rauni na rigakafi da tsarin. Mafi sau da yawa bincikar lafiya adam babesiosis a arewacin Amurka, amma akwai lokuta na ta ganewa a kasashen Turai.

American kaska typhus

Monocytic ehrlichiosis mutum dole ne a iya bambanta daga American kaska ricketsiosis - a rare cutar lalacewa ta hanyar kwayoyin cuta na Rickettsia iyali. Vector iko ne guda kwari da za su iya harba da mutum monocytic ehrlichiosis. Lokacin da typhus lura tsanani ciwon kai da kuma tsoka aches, zazzabi, jin sanyi, asarar fuskantarwa a sarari. A mafi yawan lokuta, bayan biyu - kwanaki shida bayan da kaska cizo akwai wani fata rash, da farko rufe da itãcen dabĩnai, wuyan hannaye, tafin kafa, idãnun sãwu biyu da forearms. Daga baya, da rash shimfidawa da fuska, jiki da kuma ƙananan kafa. Wani lokaci akwai tashin zuciya, amai da kuma ciwon mara. A wasu lokuta, a lokacin da cutar ba a gano cutar a lokacin, ko kuma in babu isasshen magani, da bayyanar cututtuka na Tick-haifa Amurka ricketsiosis iya zama barazana ga rayuwa. Annobar cutar da cutar, an rubuta su a yankuna daban-daban na Amurka.

bincikowa da

Gane asali mutum monocytic ehrlichiosis, kamuwa da cuta wadda ke iya haifar da yiwuwar hatsari cututtuka, kana bukatar ka yi amfani da wani sosai likita jarrabawa, bincike na cuta-free kuma na musamman dakin gwaje-gwaje gwaje-gwaje. Jini gwaje-gwaje sau da yawa nuna hankula manifestations na mutum monocytic ehrlichiosis: dakushe ja jini cell count (thrombocytopenia), akan rage wasu fari cell count (leucopenia), da kuma a lokaci daya karuwa a matakin na hanta takamaiman enzymes (msl, magani aspartate aminotransferase da alanine aminotransferase). A wasu lokuta, a sakamakon awon gwaje-gwaje samu pathological cerebrospinal ruwa. Bugu da kari, kirji X-ray iya gane mahaukaci canje-canje a cikin huhu (msl na huhu infiltrates ko wuce haddi da ruwa jari).

Research jini shafa a karkashin electron-katako microscope iya gane jari na kwayoyin cuta a cikin vacuoles na wasu Kwayoyin (musamman monocytes), amma a farkon matakai na kamuwa da cuta irin gungu ne ba ko da yaushe a bayyane. A wasu lokuta, ƙarin musamman dakin gwaje-gwaje gwaje-gwaje domin sanin takamaiman irin na kamuwa da cuta da kuma tabbatar da ganewar asali.

Irin wannan na musamman gwaje-gwaje sun hada da, misali, kaikaitaccen immunofluorescence hanya domin ganowa pathologies, wanda ya shafi nazarin magani samar a kan tushen da haƙuri da jini. Antibodies - sunadaran samar da wasu farin jini Kwayoyin - taimaka jiki yaki da gubobi da kuma cutarwa kwayoyin. Lokacin amfani tsaye ba immunofluorescence batawa na mutum takamaiman antibodies labeled da kyalli dyes, magani da aka sanya a karkashin ultraviolet radiation da kuma nazarin da shi a karkashin wani madubin gane juna antibody dauki zuwa takamaiman kwayoyin.

magani

Idan aka tabbatar da ganewar asali "mutum monocytic ehrlichiosis," fiye da mu bi da wannan cuta? Mafi sau da yawa, likitoci rubũta da misali sashi na tetracycline maganin rigakafi. Kamar yadda wani madadin far ne, wani lokacin a kan yi amfani da tushen doxycycline. A tsanani lokuta, da mãsu haƙuri iya bukatar kwararren dubawa a wani asibiti. Bugu da kari maganin rigakafi, yana yiwuwa ya dauki wani magani likita ta izni domin sauƙaƙe da hankula bayyanar cututtuka na kamuwa da cuta.

rigakafin

Idan ka rayu a yanayin yankin, wanda aka sanaki ticks yiwuwar m, ciki har da yan dako na kwayoyin cutar iyali Ehrlich, shi ne kyawawa, ka dauki dace riƙi shirinku. Idan kana barin kasar, tuna cewa kana da shi ta da hadarin ƙulla rashin lafiya mai tsanani kamar monocytic ehrlichiosis mutum. Photo mites aka tabbatar dako na kwayoyin cuta, za su zama vigilant, duk da haka, sanin m, maƙiyi a fuskar bai isa ba. Sa dogon wando, shirts da kuma T-shirts tare da dogon hannayen riga. Yana da muhimmanci a ci huluna, da mafi kyau - m-brimmed huluna, kamar yadda da yawa mites rayuwa a cikin bishiyoyi. Zabi haske-canza launin tufafi, tun da shi ne mafi sauki ga wani kwari. Yi amfani da musamman kayan aikin-m da kuma tabbatar da duka biyu fata da kuma tufafi sau da yawa za su iya duba. Mai kaska cizon faruwa a fatar kan mutum, kuma wuyansa.