Nonsteroidal anti-kumburi kwayoyi - mai dama, ko da wani jinkirin kisa?

Mafi sau da yawa amfani a asibiti yi protivovspalitelnye nonsteroidal kwayoyi, ko NSAIDs. Suna nada a kumburi tafiyar matakai na bambancin etiology for locating tushen kumburi, zafi taimako, zazzabi, rage hadarin thrombosis (saba duk asfirin). Bisa kididdigar da daga WHO, wadannan kwayoyi jan game da 30 da mutane miliyan a kowace rana, tare da kawai daya bisa uku na su - a ganin likita. Ko da more m lambobi, musamman a rheumatic cututtuka. An gano cewa anti-kumburi kwayoyi ga hadin gwiwa ta sallami game da 80% na rheumatologists.

Amma ko da wadannan kwayoyi ne m kamar yadda rare? Clinical tasiri na ba a tambaya ba, amma yana da wasu gazawa, saboda ko da kananan allurai domin gajere gwamnatin iya ba illa a 25% da marasa lafiya, da kuma a 5% na lokuta masu rai barazana. Musamman, shi shafi tsofaffi, kuma a gaskiya suka yi up 60% na dukkan NSAID masu amfani.

Lokacin da baya a cikin 70 na gano da manufa na mataki na wadannan kwayoyi (hanawa na cyclooxygenase aiki, babban enzyme da hannu a cikin metabolism na prostaglandins), ya bayyana cewa gefen sakamako yana daure wa zama da ci gaban munanan a koda jini ya kwarara, da kuma gastrointestinal fili. Bayan duk, prostaglandins (PGs) taka muhimmiyar rawa a nan. A cikin 90s, sabon abubuwa game da rawar da GHGs a cikin shakka daga cikin mafi muhimmanci matakai a cikin jikin mutum. Haka kuma, anti-kumburi kwayoyi vozdestvuyut dukan kewayon rayuwa halayen, musamman ga jini clotting da jijiyoyin bugun gini sautin, kashi metabolism, embryogenesis, ci gaban da juyayi tsarin Kwayoyin, nama gyara da kuma waɗansu da yawa.

A daidai wannan lokaci an bayyana cewa akwai biyu isoforms na cyclooxygenase: Cox-1 da kuma Cox-2. Bugu da ƙari, na farko alhakin da al'ada aiki na gabobin a salon salula matakin, da kuma hanawa na biyu kawai ya nuna da warkewa sakamako. Saboda haka, samar da anti-mai kumburi da kwayoyi da za su iya aiki selectively a kan Cox-2, yana yiwuwa a rage girman da ya faru na gefen effects kuma mafi amintattu magani.

Daya daga cikin wadannan zabe jamiái da aka ibuprofen. Kamar yadda kusan duk nazarin, hadarin da ya faru na gastrointestinal pathologies a da liyafar da aka kadan idan aka kwatanta da, misali, piroxicam.

In mun gwada kwanan nan gano wani gefen sakamako da cewa yana sa ba-steroidal anti-kumburi kwayoyi. Su rage jijiyoyin bugun gini sautin, wanda shi ne musamman kawo hadari ga mutanen da fama da cutar zuciya. A marasa lafiya samun NSAIDs ya auku, kamar yadda mai mulkin, ya karu jini, kazalika da mafi yawan tsofaffi wanda rubũta wadannan kwayoyi ga rheumatic zafi, yawanci riga na da tarihin hauhawar jini.

Bugu da ƙari, NSAIDs rage tasiri na diuretic mataki na dama antihypertensive magunguna. A musamman, da talakawan warkewa allurai indomethacin, naproxen da piroxicam soke magani dauke da furosemide da hydrochlorothiazide, prazosin kamar kwayoyi ko captopril. Duk da haka, kamar yadda ya zama sananne cewa zabe mataki na kwayoyi a kan daban-daban isoforms na Cox, kamar yadda aka ambata a sama, ba muhimmanci shafi zuciya da jijiyoyin jini tsarin. Kamar haka, akwai zauna a manyan filin daga aiki ga halittar sosai zabe kwayoyi tare da kadan tasiri a kan jini, kuma mafi daidaituwa ga tsofaffi. Kuma wadannan kwayoyi sun fara bayyana. Alal misali, Cox-2 selectivity mallaka gagarumin meloxicam, celecoxib.

Abin baƙin ciki, ba kawai mazan Luda sau da yawa kansu rubũta nonsteroidal anti-mai kumburi da kwayoyi don colds, misali, ba tare da fahimtar abin da zai yiwu sakamakon. NSAIDs ne ainihin wuya maye gurbin wani abu, amma don kimanta tasiri na mai magani ga duk yiwu kasada iya kawai m likita.