"Capecitabine": umarnin don amfani, real takwarorinsu, saki form, da manufacturer. "Capecitabine-TL": sanarwa

Capecitabine (Latin Capecitabinum.) - wani abu da yake a fluoropyrimidine carbamate wanda aka samu. A nasa ne da rukuni na antimetabolites - takamaiman mahadi iya hana ci gaban da m siffofin maruran. A amfani a irin wannan abubuwa sun samo asali ne a shekarar 1960 g. Farko tabbatacce sakamakon da aka samu ta hanyar karatu a beraye. Wani lokaci daga baya, an gano ingancinta da magani daga wasu ciwon daji cututtuka a cikin mutane.

Yau, da yawa anticancer kwayoyi dauke da aiki abu capecitabine. Reviews na da yawa marasa lafiya ce game da nasarar da aikace-aikace na irin kayayyakin aiki a anticancer far.

Warkewa da kaddarorin

Formula capecitabine - 5'-deoxy-5-fluoro-N - [(pentyloxy) carbonyl] cytidine. Antimetabolites sinadaran kungiyar da aka wakilta wani adadin abubuwa da suke da irin wannan a cikin yanayi da kayayyakin da metabolism (metabolism) adam. Suna kuma iya tafiyar da rayuwa halayen, da kuma daidaita su zuwa rage gudu wasu daga cikin biochemical tafiyar matakai. Kamar wancan akwai wani matsalar aiki na samfur a muhimmanci da ƙari Kwayoyin da kuma hanawa na girma a lokacin da yin amfani da shirye-shirye dangane da abu capecitabine. Reviews mutane suna magana ne game rage girman siffofin maruran. Wannan inji na mataki ne ake kira cytostatic.

Wadannan Properties damar yin amfani da abubuwa antimetabolitnyh su a anticancer far. su tabbatar da inganci da m marurai na gastrointestinal fili da kuma mammary gland. A wannan yanayin, mai kyau sakamakon yana da biyu da monotherapy da hade da wasu jamiái. Don kwanan wata, a kan tushen da anti-metabolites halitta fiye da 800 kayayyakin, amma har yanzu ya ci gaba da binciko sababbin kungiyoyin na mahadi.

inji na mataki

Capecitabine Rayar da ya auku a cikin tsokoki na ƙari, bayan da shi zai fara zuwa exert ta mai guba sakamako a kan Kwayoyin (cytotoxic inji). Wannan abu ne da hannu a cikin metabolism na dauki da take kaiwa zuwa gaskiya cewa lafiya da ƙari Kwayoyin suna tuba zuwa cytotoxic analogs. Kamar wancan akwai wani take hakkin sa abu dole ga DNA kira, kuma saboda haka, da rabo tsari.

Tun da Kwayoyin gushe kara da lambobi. A wani labari, akwai wani "canzawa" na daya wani abu, inda ya isa a gina jiki kira ne a lokacin da damuwa da shan kwayoyi tushen capecitabine fili. Guide bayyana a cikin daki-daki, wannan tsari.

The inji wannan canji minimizes da yiwuwar lalacewar lafiya Kwayoyin. Capecitabine ne mafi mayar da hankali a cikin ƙari kanta, fiye da a cikin kewaye kyallen takarda. Irin wannan fasalin ne kasa cutarwa ga jiki a lokacin da wani mutum da ake bi da ga wani magani dogara ne a kan abu capecitabine. Umarnin don amfani da shawarar karbar kudi a tsananin ayyana allurai da aka ƙaddara da halartar likita.

Zauna dũkiyõyinsu a cikin jiki

A kan samun capecitabine ne ta m sha a cikin gastrointestinal fili. Idan ka ci a wannan lokaci, da tsari zai rage gudu. Saboda haka, dangane da liyafar antimetabolite kwayoyi ne da za'ayi bayan ingestion. Bugu da ari canji yakan faru a cikin hanta abu, wani adadin capecitabine kuma ta metabolites kisa ga sunadaran (msl, albumin). A ganiya magani matakan kai bayan 1.5 -3 sa'o'i bayan miyagun ƙwayoyi aikace-aikace. Wannan magana da miyagun ƙwayoyi "Capecitabine" wa'azi da shi. Analogs da irin wannan pharmacokinetics.

Mafi yawa daga cikin abu ne excreted a cikin fitsari, m - tare da tumbi. Haka kuma, ba kawai ya fita daga jiki capecitabine canzawa (game da 3%), amma Kalam. Wasu daga cikin su suna metabolized zuwa kasa aiki mahadi. A zama da kuma canji na capecitabine a cikin jiki ba ta shafa jinsi, shekaru, tseren.

Lokacin gudanar?

Capecitabine cikin daban-daban formulations gudanar don marasa lafiya da cutar sankarar nono, ciki har da metastatic mataki. A wannan yanayin, da kayan amfani a cikin tsarin kadai, ko a hade da magani tare da contraindications ko rashin inganci na jiyyar cutar sankara. Mafi sau da yawa, capecitabine hade tare docetaxel.

Haka kuma an wajabta ga marasa lafiya da ciwon daji na ciwon, esophagus, ciki, pancreas, colorectal ciwon daji, duka a cikin gida baza na mataki, da kuma a lokacin metastasis. A lura da ciwon daji ta hanji ne ma sananne "capecitabine". Umarnin don amfani a hankali bi da shawarar sashi da kuma bi da shawarar da halartar likita.

Hulda da sauran kwayoyi

Idan jiyyar cutar sankara tabbatar m, wani Oncology gwani iya rubũta a hade magani, wadda za a yi amfani da "capecitabine". Umurnai na amfani na samar da wani jerin albarkatu, wanda shi ne zai yiwu a samu nasarar Mix.

Alal misali, tare da "docetaxel" - miyagun ƙwayoyi cytotoxic mataki irin ciwon kayan lambu asalin. Shi ne iya dage na dogon lokaci a cikin sel a high yawa. Duk da haka, irin wannan mai hade da jamiái da aka contraindicated ga mutane tare da yawan platelets da neutrophils 100,000 / ul kuma 1500 / l, bi da bi. Har ila yau, "Docetaxel" Bai shafi marasa lafiya da wani ƙara kudi na bilirubin. A wannan yanayin, zai yiwu m sakamakon. Idan "Docetaxel" saboda wasu dalilai "fall" na lura regimen, ci gaba da far "capecitabine", amma a rage yawan allurai.

A taron na hypersensitivity halayen magani "capecitabine" da "docetaxel" tasha da kuma kawar da cututtuka sa. Students hada supplementation tasowa oncologist gwani artisan. Wannan makirci ne gyara a taron na mai guba effects.

"Capecitabine" ba a nada a lokaci guda "Sorivudinom" - wani antiviral wakili. Wannan hade na iya kara yawan guba na farko miyagun ƙwayoyi. A hada da yin amfani da miyagun ƙwayoyi antiepileptic "phenytoin" qara taro na karshen a cikin jini jini. Shi ne kuma zai yiwu na jini cuta a cikin yin amfani da coumarin anticoagulants da kuma wajen, inda babban bangaren - capecitabine. Umurnai na amfani gargaɗi kan yiwu sakamakon, don haka dole ne ka farko familiarize kanka tare da shi.

Wanda aka contraindicated?

A dalilin cewa an contraindicated ko aka iyakance ga miyagun ƙwayoyi iya zama:

• High ji na ƙwarai (hypersensitivity dauki).
• A gaban mai tsanani na koda ko hanta insufficiency.
• Daban-daban, saukarwa na ciki (da miyagun ƙwayoyi rinjayar da 'ya'yan itace), tare da togiya lokuta inda mahaifiyar ta rayuwa da aka sa a cikin fifiko.
• Ciyar da jariri ciyar.

Har ila yau, samun capecitabine iyaka ga mutane da jijiyoyin zuciya da cututtukan zuciya da (CHD), a lokacin da wani jihar ya karu taro na bilirubin a cikin jini, hanta da cutar metastatic da take hakkin ta na asali ayyuka. babu shiri bada shawarar ga minors da kuma tsofaffi. Wannan ya tabbatar da miyagun ƙwayoyi "Capecitabine" wa'azi da shi. Shedu magana game da dama illa da kuma mai guba effects a cikin magani. Saboda haka, capecitabine far daukan wuri a karkashin tsauraran dubawa da wani gwani oncologist.

Ashe, akwai wani illa?

Bayan shan miyagun ƙwayoyi iya zama ciwon kai, Jihar gajiya, lethargy, wani rauni. Rashin barci iya faruwa, ko mataimakin versa - drowsiness. A rare lokuta - asarar daidaituwa da kuma balance, rikice.

Side effects a kan zuciya da jijiyoyin jini tsarin ne anemia (anemia). Don a karami har da zai iya haddasa angina, tsokar ischemia, bugun jini, zuciya rashin cin nasara da sauransu. Idan tsari na numfashi gabobin suna da hannu, ƙila a sami nakasa daga 'ya'yan numfashi, ciwon makogwaro, tari. Sosai da wuya - huhu embolism, huhu spasms.

Lokacin amfani da abun da ke ciki kadai ko a hade magani yiwu illar kan musculoskeletal tsarin. Yana bayyana kanta a zafi a cikin wata gabar jiki da kuma kugu, tashi hypertonus tsokoki (myalgia), hadin gwiwa zafi (arthralgia).

A fata ƙila za a shafa. Na iya haifar da dermatitis, erythema, wuce kima rashin ruwa na fata, redness, tingling, numbness, peeling, itching, ta ƙara pigmentation, lalacewar rinjayar da kusoshi. A rare lokuta akwai fata fasa, hypersensitivity zuwa ultraviolet radiation, peeling kuma Ya ƙãra fragility na ƙusa faranti.

Daga cikin wasu m events na iya faruwa dauke da kwayar cutar matakai saboda runtse jiki ta defenses. Bayan miyagun ƙwayoyi far sa wani karu a jini platelets da farin jini Kwayoyin. Irin wannan manifestations bayyana a medicament "Capecitabine" umurci manual. Analogues bayar da wannan effects.

da miyagun ƙwayoyi

"Capecitabine" dace kawai na ciki amfani. Yawancin lokaci aka wanke saukar da ruwa bayan rabin awa bayan wani abinci, amma ba daga baya. A kullum kashi ne m da halartar oncologist, dangane da girman da marurai, da cin mataki, da jimlar jiki surface area. Yana da kyawawa da cewa gwani ya riga ya da basira da aiki tare da wannan magani. A mafi akai-akai wajabta sau biyu-kullum - a sãfiya da maraice. A wannan yanayin, dukan shakka yana da makonni biyu, sa'an nan - hutu na kwana bakwai, bi da wani sake magani.

Ga marasa lafiya da na koda insufficiency, da kullum allurai rage. By rage yawan leukocytes (leucopenia) da kuma neutrophils (neutropenia) a cikin jini ci gaba da shan miyagun ƙwayoyi. Saboda haka ya bada shawarar a wajen "Capecitabine" umurci manual. Kamancin ko analogues gudanar a himma da halartar likita.

yawan guba

Akwai da dama digiri, bisa ga abin tasowa mai guba sakamakon da miyagun ƙwayoyi "capecitabine" (Umurnai na Amfani). Reviews na mutane da yawa da cewa wannan wani mutum tsari.

Akwai da dama digiri na yawan guba:

• 1 digiri. Akwai 'yan illa.
• 2 digiri. The m zawo (har zuwa sau 4 a rana) bi da reshe kumburi, redness, aiki cuta, mai kaifi karuwa a bilirubin. A wannan mataki, da liyafar katse capecitabine har ãyõyin yawan guba na mataki 1.
• 3 digiri. Zawo rãyar har zuwa 9 sau per day. Yana auku malabsorption (sprue). A lokacin da wannan aka lura da wani karfi fata peeling, redness, blisters kuma miyakunsa. Akwai kaifi sha raɗaɗin a cikin extremities, rage aiki. Bilirubin an karu da sau 3. A wannan mataki na jiyya aka katse, kuma bayyanuwar yawan guba na 1 digiri ci gaba da samun nufin a cikin ƙananan kashi.
• 4 digiri. More m zawo - har zuwa 10 sau da rana. Stool tare da jini. Akwai bukatar gabatarwar kwayoyi, bypassing da gastrointestinal fili. Idan alamun wannan mataki na jiyya ya kamata a tsaya, kuma bai taba koma.

Abin da matakan bukatar mu kiyaye aminci?

A hanya na lura kamata faru a karkashin kusa likita dubawa. A gwani dole ne dace gane mai guba bayyananen -. Ko tashin zuciya, zawo, da dai sauransu Bayan ganewa na wadannan siffofin, da magani aka gyara ba. Idan dole, kawar da cututtuka, rage kullum kashi, yin hutu. Magani ya kamata a ci gaba, idan ãyõyin yawan guba ba barazana ga rayuwa.

Don mutane da jijiyoyin zuciya da cututtukan zuciya da kula gwani ya zama musamman sosai. A wannan yanayin, kana bukatar lokaci ya bayyana da mummunan tasiri a kan zuciya da jijiyoyin jini tsarin da kuma a lokacin da za a sa dole shirye-shirye.

Masana sun dena yin amfani da dũkiyõyinsu a yara yi. A tasiri na ta yin amfani da bai da aka kafa domin yara. Idan magani ne hõre wata mace na haihuwa, ta kamata a rika kan tasiri na capecitabine a kan tayin. A lokacin hanya na far, ta kamata amfani da m hana.

Shirye-shirye da kuma analogues

Akwai da dama kayayyakin a kan tushen da capecitabine. A cikin Rasha kasuwar akwai 7 ciniki sunan da miyagun ƙwayoyi, samar da dama cikin gida da kuma kasashen waje da kamfanoni. Ga misali:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Tun kafuwar duk wadannan hanyoyi daya da wannan aiki sashi - capecitabine, don su koyar da zai zama irin wannan. Yawancin lokaci shi nuna wani tebur don kirga sashi ba jiki nauyi da kuma lura gyara kewaye idan wata ãyã daga sãɓãwar launukansa digiri na yawan guba.

Yana da muhimmanci a fahimci cewa, abu na farko da za a karanta, a lokacin da aka nada, misali, "Capecitabine TL" - wa'azi da shi. The bayanai žunsa ba dace da kai-gwamnati kayan aikin! All lissafin alaka da kashi da kuma magani regimen, samar da wani likita - oncologist tare da isasshen iyawa a cikin wannan al'amari. Kai gwamnatin anticancer jamiái haddasa irreparable cutar da jiki.

Bari mu bincika wasu daga cikin kwayoyi.

Description of shirye-shirye

• "Capecitabine - TL" da ke sa da Rasha kamfanin OOO "Technology magunguna." A key bangaren - capecitabine. Umurnai na amfani, da saki nau'i na amfani ga mutane da yawa. Ka yi la'akari da cikakken bayani. Wannan kwamfutar hannu, film-mai rufi. Da abun ciki na aiki abu - 150 ko 500 MG. Karin aka gyara: cellulose, lactose, croscarmellose sodium, hypromellose, magnesium stearate. Daya kunshin iya zama 60 ko 120 Allunan, dangane da sashi daga cikin miyagun ƙwayoyi "Capecitabine - TL". Umarnin dole ne dauke da cikakken bayani game da yin amfani da kudi.
• "Capecitabine" - m samfurin da wannan aiki sashi. Bayanin ne kama da nufin jera a sama. Saki nau'i na da miyagun ƙwayoyi "Capecitabine" - Allunan. Umurnai na amfani ne ma a kewaye a cikin kunshin.
• "Kabetsin" - anticancer wakili na Rasha yi ( "Company" Deco "). Samfurin fom - Allunan film mai rufi da 150 ko 500 MG na aiki abu. Secondary sinadaran: microcrystalline cellulose, crospovidone, sitaci, magnesium stearate. Bar daga Pharmacy kawai ta sayen magani.
• "Kapetsitover" - wani samfurin na Rasha kamfanin OJSC "Veropharm". Wannan anticancer wakili samuwa a allunan 150 ko 500 MG na 60 - 120 guda. Bayan capecitabine, a cikin shirye-shiryen da ya hada da lactose, cellulose, croscarmellose sodium, sodium stearate, kuma hypromellose.
• "Kapametin FS" - samar da Rasha kamfanin "Nativ" - wani aiki takara a shirin na shigo da canzawa da kwayoyi. "Kapametin FS" saki wani sashi na 150 - 500 MG aiki wakili - capecitabine. Umurnai na amfani (kuma m Saita a cikinsa) zai gaya maka yadda da yawa Allunan da fakitin - 60 ko 120.
• "Tutabin" - waje samfurin a kan tushen da capecitabine. Yana samar da wani Argentine kamfanin Laboratorio VARIFARMA SA, wanda kuma rejista wakili. "Tutabin" da aka samar a cikin nau'i na alluna da wani aiki sashi abun ciki na 500 MG. Marufi - kwali akwatin tare da umarnin kawota.
• "Xeloda" - wani antitumor wakili. Samar a Switzerland ta "by F. Hoffman La Roche" da rassa da kuma ofisoshin wakilci a sauran kasashe - Mexico da kuma Amurka. A cikin Rasha kasuwar akwai 5 kwayoyi tare da cinikayya sunan. Samfurin fom - Allunan (150 - 500 MG) a 60 ko 120 guda. a guda kunshin.

reviews

Reviews na aiki a kan tushen da dama kwayoyi capecitabine. Mafi yawansu ba su kasance m, amma akwai ma korau reviews. Duk da haka, wannan ba ya faye hali wadannan kudi a matsayin mai kyau ko mara kyau, saboda ya kamata ka ko da yaushe la'akari da individuality na jiki na kowane mutum. Karbar guda wajen mutane daban-daban ba bayar da wannan sakamakon. Na bayar da muhimmanci shi ne gaskiya wanda jiki da aka buga neoplasm da kuma tsawon lokacin da aka faruwa.

Mutanen da suka dauki da miyagun ƙwayoyi, ya ce wani karfi mai guba sakamako bayan kwanaki da dama na shiga. Duk da haka, da yawa bayar da rahoton gagarumin ci gaba a cikin hãlãyensu, kuma ko da shigarwa cikin gafarta musu. An muhimmanci yanayin da miyagun ƙwayoyi zai yi aiki da yiwu ga wani mutum guda, a consulting oncologist da kuma tsananin riko ga umarnin game da magani.