Da miyagun ƙwayoyi "Doxorubicin": umurci manual, reviews, photos, saki form, sashi, ajiya. "Doxorubicin-Lance": umarnin don amfani da

A ciwon daji ne musamman kawo hadari ga rayuwar dan Adam. Ya kunshi m da uncontrolled proliferating Kwayoyin, wanda suke iya shiga cikin kewaye nama da kuma metastasize zuwa wasu gabobin.

A ci gaba da kwayoyi da kuma jiyya ga irin cututtuka ne wani muhimmin aiki. Abin takaici, har yanzu babu daya har karshen kuma I ba su yanke shawarar. Ko da yake har yanzu akwai kwayoyi da cewa zai iya rage da rabo daga ƙari Kwayoyin. Daya daga cikin su mayar da magani "Doxorubicin". Umarnin don amfani da wani hoto daga cikin miyagun ƙwayoyi za a rufe a cikin wannan labarin. A da shi za ka sami bayani game da yadda za a ci gaba da ce hanyar a wanda ya samar da shi ne don sayarwa, da kuma more.

Marufi, abun da ke ciki, da kuma siffar description

A abin da fom da aka sayar "Doxorubicin"? Umurnai na amfani nuna da wadannan iri samfurin:

• Lyophilizate ga shirye-shiryen da mafita ga intravascular da intravesical allura. Shi ne ja-yellow porous taro da ya ƙunshi aiki abu kamar doxorubicin hydrochloride. Kamar yadda ƙarin sinadaran yin amfani da mannitol. Magani da aka sayar a cikin kwalabe, a kewaye a cikin wani kwali akwatin.
• Mayar da hankali ga samar da wani bayani ga intravascular da intravesical allura. Yana da wani ja da m ruwa wanda ya ƙunshi doxorubicin hydrochloride kuma shi ne samuwa a cikin kwalabe da cartons.

A pharmacology da miyagun ƙwayoyi

Menene wannan magani kamar yadda "Doxorubicin"? Umurnai na amfani (saki nau'i na da miyagun ƙwayoyi da aka nuna a bisa) rahoton cewa yana da wani anti-ƙari anthracycline kwayoyin, wanda aka ware daga al'adu na naman gwari Streptomyces peucetius. Shi ne iya exert antimitotic da antiproliferative effects.

Hulda da DNA, da medicament damuarn RNA polymerase, DNA polymerase da topoisomerase irin 2, da kuma ma activates samar da free radicals da kuma abubuwa a kan cell bango. A sakamakon irin wannan tasiri slows DNA kwafi da nazarin halittu nucleic acid kira.

Ba shi yiwuwa ba a lura da cewa muna la'akari da nufin yana da wani kai tsaye cytotoxic sakamako. A Kwayoyin nuna wani musamman ji na ƙwarai to da miyagun ƙwayoyi a cikin G2-lokaci da kuma S-lokaci na rayuwarsu.

sanadin motsi Properties

Me sanadin motsi sigogi muhimmi a da miyagun ƙwayoyi "Doxorubicin"? Umurnai na amfani furta cewa, bayan igiyar jini allura, da kayan aiki ko da yaushe rarraba multiphase. A lokacin farko da minti 5 na medicament hanzari kama nama, da ta maida hankali a jini rage-rage hanzari. Kamar yadda a karo na biyu lokaci, shi ne da za'ayi m miyagun ƙwayoyi kwayoyin daga kyallen takarda.

Fi mai da hankali aiki miyagun ƙwayoyi a cikin hanta, kodan, saifa, huhu da myocardium. Yana kuma da ke shiga mahaifa da aka excreted tare da nono.

Mayar da martani ga jini sunadaran ya auku da 75%. Metabolism da kwayoyi a cikin hanta, game da shi, ya kafa wani aiki wanda aka samu kamar doxorubicinol.

A lokacin akan rage free radicals enzyme kira zai iya shafar ci gaban cardiac yawan guba.

Half-rai na doxorubicin da kuma irin wannan doxorubicinol kuma shi ne game da 20-48 hours.

Aƙalla 40% na kashi daga cikin miyagun ƙwayoyi da aka saki tare da bile, kuma kawai 6-11% na doxorubicin Kalam, kwanaki 5 da ake samu a fitsari.

alamomi

miyagun ƙwayoyi "Doxorubicin" iya nada a abin da cututtuka?

Umurnai na amfani (ga mafitsara ciwon daji ne mai kayan aiki amfani da sau da yawa sosai) shi ya furta cewa, magani ya yi aikin da kyau a lokacin da:

• thyroid gland shine yake ciwon daji, Kaposi ta sarcoma da Ewing.
• Wilms 'ƙari, na ciki da ciwon daji, kananan cell nau'i na huhu ciwon daji.
• insulinoma nono, da mesothelioma.
• esophageal ciwon daji, carcinoid, neuroblastoma.
• osteogenic sarcoma, primary hepatocellular sankara, ba-Hodgkin ta lymphoma .
• Ciwon daji na prostate gland shine yake, ciwon daji na kai da wuya, m thymoma.
• cutar sankarar mahaifa, wasu iri testicular marurai.
• igiyar ciki sarcoma, endometrial ciwon daji, Hodgkin ta cutar.
• rhabdomyosarcoma, m da cutar sankarar bargo.
• kullum lymphocytic cutar sankarar bargo, mahara myeloma.

contraindications

Mene ne yanayin haƙuri rubũta hana shi da miyagun ƙwayoyi "Doxorubicin"? Umarnin don amfani, real oncologists ce cewa kayan aiki ya tabbatar da ba matukar tasiri a cikin:

• wayar zuwa doxorubicin ko wasu miyagun ƙwayoyi abubuwa, kazalika da wakilan anthracyclines da anthracenediones.
• kafin far, ko wasu mambobi na anthracycline anthracenediones a iyakance allurai, kazalika da hanta gazawar (tsanani), tsokar zuciya infarction, arrhythmias, m kwayar cututtuka da kuma zuciya rashin cin nasara (ga igiyar jini gwamnati).
• m marurai, germinating a bango na mafitsara, urinary fili cututtuka da kuma cystitis (ga intravesical).

Tare da matsananci hankali, wannan magani ya kamata a yi amfani da mutanen da suka karbi m jiyyar cutar sankara, kazalika da matsalolin na daban domin cardiotoxicity, take hakkin da hanta, bargo infiltration na ciwon daji Kwayoyin kuma kiba.

Bugu da kari, a hankali dauke da miyagun ƙwayoyi An wajabta ga yara da kuma mutane na ci-gaba shekaru, da kuma wani bangare na Multi-jinsin da kuma multicomponent antitumor far.

Drug "Doxorubicin": umarnin don amfani, sashi

Bisa ga umarnin, dauke da miyagun ƙwayoyi za a iya gudanar da intraarterially, intravenously da intravesically. Ya kamata kuma a lura da cewa, wannan kayan aiki da za a yi amfani da singly ko a hade tare da sauran cytostatic kwayoyi a daban-daban dosages.

Reconstituted miyagun ƙwayoyi bayani "Doxorubicin" ne da za a yi amfani da nan da nan bayan ta yi.

Igiyar jini allura halitta

A shawarar sashi na monotherapy "Doxorubicin" ta sake zagayowar ne 60-75 MG / sq. m kowane makonni uku. Yawanci, da miyagun ƙwayoyi ne allura sau daya. Duk da haka, wannan kashi iya gudanar da mahara injections (a cikin wani adadin 25-30 MG / sq. M kowace rana ga na farko 3 kwanaki na sake zagayowar).

Don rage mai guba sakamako na hanyar amfani da mako-mako gwamnati na 10-20 MG / sq. m sau a mako.

Lokacin hadu da sauran anticancer jamiái aiki medicament aka gudanar a wani sashi sake zagayowar a wani adadin na 30-60 MG / sq. m kowane 4 makonni.

Maimaita darussa na magani da za'ayi kawai bayan kawar da duk bayyanar cututtuka na yawan guba.

A duka kashi na miyagun ƙwayoyi kada ta kasance fiye da 550 MG / sq. m.

Ciki-jijiya gwamnati na wani wakili

Ta yaya ne ciki-jijiya allura "Doxorubicin" miyagun ƙwayoyi? Shiryar da jihohin da samar da sidetone mutane da hepatocellular sankara aiki medicament da za a gudanar da na kowa hanta jijiya a cikin wani sashi na 35-150 MG / sq. m. A daidai wannan lokaci ne tsakanin hawan keke ya zama daidai daga 3 makonni zuwa watanni 3.

A gabatarwar da miyagun ƙwayoyi a cikin mafitsara

Kamar yadda mafitsara allura miyagun ƙwayoyi "Doxorubicin-Teva"? Umarnin don amfani da rahoton cewa wannan sashi na nufin for intravesical gwamnati ya zama 35-50 MG da kafuwa.

Medical hanyoyin dole ne a da za'ayi a kan jinkiri na 7-28 kwanaki, dangane da manufar (rigakafin ko magani).

Taro na miyagun ƙwayoyi bayani ya zama 1 MG / 1 ml ruwa bayani ko ta jiki.

Instillation aka yi cikin sa'o'i 2. A ƙarshen haƙuri kamata komai cikin mafitsara.

illa

Shiri "Doxorubicin", wanda wa'azi aka bayyana a sama na iya haifar da wadannan gefen halayen:

• amai, ciwon mara, tashin zuciya, colitis, stomatitis, zawo, esophagitis, na baka mucosa hyperpigmentation, anorexia, ta ƙara bilirubin maida hankali a cikin jini, gastrointestinal zub da jini, ta ƙara hanta transaminases.
• kashi-dogara reversible leukopenia, thrombocytopenia, anemia, leukopenia, neutropenia.
• sinus tachycardia, atrioventricular block, tachyarrhythmia form congestive zuciya rashin cin nasara, bradycardia, thrombophlebitis, da cuta reshe block, munanan a kan ECG, na ramin zuciya arrythmia, na huhu embolism, phlebitis, thromboembolic rikitarwa.
• amenorrhea, oligospermia, hyperuricemia, urinary ja batawa, azoospermia.
• conjunctivitis, keratitis, lacrimation.
• gefe neurotoxicity, seizures, coma.
• edema, reversible alopecia, photosensitivity, fata hyperpigmentation, rash, itching, ciwo mai tsanani, rash, erythema, m epidermis.
• dermatitis, rash, bronchospasm, fata yankin Flushing, anaphylaxis.
• Local phlebitis, alama kumburi, fleboskleroz, thrombophlebitis, gida zafi, nama necrosis.
• polyuria, nocturia, dysuria, necrosis na mafitsara membranes, hematuria, rashin jin daɗi, m urination.
• erythematous striation a allura site.
• gajiya, malaise, zazzabi, jin sanyi, ci gaban lymphocytic ko myelocytic cutar sankarar bargo (m), hyperuricemia, tides, nephropathy.
• miki 12 duodenal / ciki, biliary sclerosis.

bayyanar cututtuka na yawan abin sama

Mene ne alamun yawan abin sama faruwa lokacin da ka yi amfani da manyan yawan "Doxorubicin" miyagun ƙwayoyi? Umurnai na Amfani jihohin da wani yawan abin sama na kudi iya kai wa ga mai guba bayyanar cututtuka suna bayyana ta narkewa kamar tsarin, kazalika da a tsanani myelosuppression. Bugu da kari, hakan allurai da miyagun ƙwayoyi iya zama quite sauki sa m cutar zuciya.

An maganin guba da miyagun ƙwayoyi "Doxorubicin" ba ya wanzu. A yawan abin sama ya shafa gudanar symptomatic far. Har ila yau, an kwantar da ake bi da tare da antibacterial kwayoyi.

miyagun ƙwayoyi interactions

Shin yana yiwuwa a hada da wasu kwayoyi da miyagun ƙwayoyi "Doxorubicin"? Umurnai na amfani nuna cewa a lokacin da ka yi amfani da wannan kayan aiki a hade tare da sauran cytotoxic kwayoyi sau da yawa bayyana su ƙari yawan guba.

Lokacin da mai hade da miyagun ƙwayoyi da sauran cytotoxic kwayoyi, wanda da cardiotoxicity (misali, "FU" ko "Cyclophosphamide"), na bukatar da hankali da lura da na zuciya a lokacin da dukan shakka da far.

"Streptozocin" qara rabin-rai "Doxorubicin".

A far "Doxorubicin" haƙuri iya nuna alamun m hemorrhagic cystitis bayan lura "cyclophosphamide", kazalika da ƙara sabon abu na hanta yawan guba bayan lura "mercaptopurine."

Da amfani da "Paclitaxel" kafin ainihin gabatarwar "Doxorubicin" iya tsokana da karuwa a cikin jini taro na karshen.

Abin da kwayoyi suna haramta daga yin amfani da miyagun ƙwayoyi "Doxorubicin"? Umurnai na amfani (ga dabbobi ba sananne) rahoton cewa wannan kayan aiki kamata ba za a gauraye da wasu kwayoyi. Alal misali, shi ne pharmaceutically jituwa tare da "heparin", "Dexamethasone", sodium succinate, "hydrocortisone", "cephalothin", "aminophylline", "FU" da sauran anticancer kwayoyi.

Lokacin hade tare da live kwayar alluran ne yiwu kwayar kwafi kuma Ya ƙãra gefen halayen da kuma rage antibody kira a wani haƙuri ta jiki a mayar da martani ga yin amfani da alluran.

Specific shawarwari a kan yin amfani da kwayoyi

Abin da ya kamata ka sani kafin yin amfani da "Doxorubicin-Lance"? Umurnai na amfani na nuni da cewa a cikin shakka daga jiyya antineoplastic jamiái dole a gudanar da wani na yau da kullum saka idanu na hanta aiki, da hoto na gefe jini, ECG da kuma duban dan tayi na zuciya.

tallace-tallace yanayi, Hanyar ajiya da kuma shiryayye-rai

Inda ya kamata da miyagun ƙwayoyi "Doxorubicin-Lance"? Umarnin don amfani da rahoton cewa wannan kayan aiki dole ne a kiyaye a cikin wani bushe da duhu inda zafin jiki ba ya wuce biyar digiri.

A medicament aka saki a Pharmacy da takardar sayen magani kawai. Its shiryayye rayuwa ne shekaru biyu.

Price da analogues

A kudin da miyagun ƙwayoyi ne dauke 120-150 rubles a 5 ml. Idan dole shi za a iya maye gurbinsu da irin wannan hanyar a matsayin "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" da sauransu.

Mai amfani da sake dubawa na magani

Yanzu ka san yadda za a yi amfani da miyagun ƙwayoyi "Doxorubicin". Umarnin don amfani da ajiya na miyagun ƙwayoyi da aka gabatar a sama.

Quite babban yawan mabukaci reviews dangantawa da tsanani m halayen da faruwa a lokacin jiyya da miyagun ƙwayoyi. Don wadannan effects ne ciki sashin jiki hannu, zaunanniya jin rashin lafiya, gashi asara da kuma samuwar ulcers a allura shafukan.

A kan m sako su ne musamman rare. Kuma wannan ba abin mamaki bane, tun da tasiri na anticancer miyagun ƙwayoyi kamata kimanta kawai wani gogaggen gwani, bisa wani babban yawan daban-daban dalilai: da irin monotherapy ko hade far, wani ciwon daji, haƙuri da yanayin, da sauran dogon lokacin da sakamakon.