Prokinetics - abin da yake da shi? wani sabon ƙarni na prokinetics: jerin

Prokinetics - abin da yake da shi? A CIS kasashe, babu yarjejeniya game da abin da magunguna ana hada a cikin wannan kungiyar, saboda haka kowane gastroenterologist kansa kayyade cewa kawo a cikin wannan jerin, da kuma abin da ya aikata ba. Prokinetics - abin da yake da shi? Wannan abin da muka yi kokarin gano.

Definition da kuma taƙaitaccen bayanin

Prokinetics - abin da yake da shi? Wannan rukuni na kwayoyi da ta da da motility na narkewa kamar bututu da kuma hana anastaltic tãguwar ruwa.

Gastrointestinal cututtuka suna sau da yawa tare da reflux na chyme daga cikin ƙananan sassa na hanji tube a overlying, take hakkin nassi bolus ko wani stagnation a cikin hanji kashi. Duk wadannan cututtuka suna hade da sosai gabatarwa chyme da narkewa kamar tube, sa'an nan kuma cire cututtuka iya zama, shafi na ƙanƙancewa na m tsokoki a cikin ganuwar. Wannan abin da prokinetics. Su warkewa sakamako ne saboda tarewa na ion canja wurin inji (dopamine, 5-HT4 rabe, a hade), ko tasiri a kan metabolism na acetylcholine. Samar asibiti sakamako ne saboda da ƙara adadin acetylcholine a synaptic kogon ko da karawa da cholinesterase kayayyakin da kara habaka da bazuwar na ach, saukarwa kayayyakin ach jijiya endings.

Baya effects daga kwayoyi bayyana a kara cardiac esophageal sphincter sautin, fitarwa na ciki abinda ke ciki, da daidaituwa tsakanin antrum da duodenum, m hanji hanginsu.

Na farko rukuni na kwayoyi

Prokinetics - kwayoyi da kuma toshe dopamine D2-rabe, game da shi haramta motsa tsoka aiki da kuma samar da gastrointestinal zaruruwa antiemetic sakamako. Wadannan magunguna sun hada da: "metoclopramide" (ƙarni na farko wakilan - "Reglan" da "Raglan"), "bromopride", "Domperidone" (na biyu ƙarni), "Dimetpramid", "Itopride".

Prokinetic kwayoyi, yi amfani da magani na gastroezofagialnoreflyuksnoy cuta (Gerd), YAZHDPK, dyspepsia, aikin hali, takaita da esophagus bayan rauni, kuma a sakamakon adhesions, postoperative paresis baki a ciki, tashin hankali na outflow na bile, flatulence.

Har ila yau prokinetics - kwayoyi da cewa za a iya amfani da tashin zuciya da kuma AMAI lalacewa ta hanyar guba ko take hakkin da dokokin abinci, cututtuka na kwayar ko kwayan etiology, ciki a farko trimester, m jijiyoyin zuciya insufficiency, shugaban rauni, maganin sa barci, radiation da jiyyar cutar sankara. M da amai vestibular asali, kamar yadda ba zai tasiri a tsakiyar kunne da kuma medulla oblongata.

Antipsychotics taimaka tare da amai

"Sulpiride" da "Levosulpirid", shi ne a neuroleptic da irin wannan inji na mataki, su ma suna da wani m anti-emetic sakamako, saboda haka za a iya amfani da a gastroenterological yi.

"Metoclopramide" (prokinetics): umarnin don amfani da

"Metoclopramide" - a kai tsaye stimulator of m tsoka, kuma yana da dukkan dole Properties cimma asibiti gagarumin sakamako, amma saboda permeability gematogistologicheskie shingen da ya kamata a yi amfani da hankali. Zai yiwu illa kamar spasm da fuska tsokoki, da alama na "hankaka ta feet", rhythmic protrusion na harshe, bulbar cuta, spasms ekrtraokulyarnyh tsokoki, spasmodic torticollis, wuce kima sautin na extensor tsokoki, da Parkinson ta ciwo, somnolence, wani rauni, tinnitus, ciwon kai, tashin hankali, rudani.

A wasu lokuta, kyawawa, ka dauki prokinetiki? Umurnai na yin amfani da ce a ke so amfani a lokuta da hypersensitivity da miyagun ƙwayoyi, a ƙari na adrenal bawo, hanji toshewa, perforation na hanji da kuma sa su zub da jini, prolaktinozavisimoy marurai, epilepsy da extrapyramidal cuta, har zuwa 16 makonni na yaro ta gestation, a lokacin lactation, yara a karkashin 5 shekaru. Kariya kamata a wajabta a rage yawan yarda da creatinine, ta ƙara jini, asma, shekarunsu har zuwa shekaru 14.

Hadiye da magani rabin sa'a kafin a ci abinci, a kan wani kwamfutar hannu a 9:00, 12:00, 15:00, da 18:00. Duration na lura - hudu zuwa shida makonni, wani lokacin shi za a iya kara har zuwa watanni shida.

Idan saki fom - ruwa, shi ne gudanar intramuscularly ko intravenously. Domin manya da yara a kan shekaru 14 - 10 MG. Iyakar da daya lokaci - 20 MG kullum kashi - 60 MG. Da abinda ke ciki na ampoule za a iya diluted a isotonic Saline ko 5% glucose bayani.

"Domperidone": umarnin don amfani da

"Domperidone" shi ne mafi zabe dopamine tsoka mai amsa sigina shafi, kuma ba shiga cikin BBB, duk da haka lokacin da liyafar ba ci gaba illa aka bayyana a sama. Duk da haka, kara mugunya prolactin, shi triggers gynecomastia, galactorrhea, kuma babu sananniya. Bugu da kari, marasa lafiya ruwaito wani fata rash, bushe baki, zawo da kuma ciwon kai.

Ba da shawarar don amfani ga mutane da rashin lafiyan halayen ga gyara na magani, zub da jini daga gastrointestinal fili, na hanji toshewa, prolactinoma, lactation, shekaru har da shekaru 5 da haihuwa, ko yin la'akari har zuwa 20 kilo. Kariya dauki a lokacin daukar ciki, koda da kuma / ko hanta insufficiency.

Sha for minti ashirin kafin kowane abinci zuwa 10 MG, idan da ake bukata, kuma zai iya sha kafin zuwa gado. A kalla kashi da rana - 80 MG. Idan ba a lura da antacids, Munã rage mugunya na ciki da ruwan 'ya'yan itace, ya kamata su zama ware daga sha domperidone, raba cin abinci.

"Itopride": umarnin don amfani da

"Itopride" hadawa da kaddarorin da dopamine tsoka mai amsa sigina antagonist kuma a shafi na acetylcholinesterase. Sakamako a kan hypothalamic-pituitary-adrenal tsarin, da kara yawa na somatostatin da rage adrenocorticotropic hormone. A mummunan sakamako da aka bayyana a matsayin leukopenia, thrombocytopenia, hypersensitivity halayen, hyperprolactinemia, tashin zuciya, tremor, jaundice. A lokacin liyafar, shi wajibi ne don saka idanu da jihar na gefe jini, da kuma tabbatar da akwai wani illa.

Ba da shawarar for mutane da hypersensitivity na nan da nan ko jinkirta type, gastrointestinal zub da jini tarihi, obturating da hanji lumen ko matsawa daga kasashen waje jiki daga waje, ƙarƙashin da shekaru goma sha shida da shekaru, ciki, shayarwa.

Da miyagun ƙwayoyi ne riƙi baki kafin abinci ga 50 MG sau uku a rana.

Antagonists "Acetylcholine"

Wannan kungiyar hada da:

• "Aceclidine" (M-cholinomimetic).
• "Fiziostigmin" "Galantamine" "Tegaserod" "Prucalopride" (reversible cholinesterase hanawa)

Wadannan kwayoyi ciki kawai partially kamfanin na prokinetics saboda su gefe effects: illa da kan musayar potassium ions, kuma a sakamakon, tsawon kwanakinka QT tazara, wadda take kaiwa zuwa disturbances na cardiac kari. A yawan kwayoyi da aka janye daga pharmacological kasuwar domin wannan dalilin.

"Aceclidine": umarnin don amfani da

Prokinetics - abin da yake da shi, yadda kuma idan ka yi amfani da su? A cikin wani hali, a tabbatar tuntubar likita da m nazarin umarnin don amfani.

"Aceclidine" da ake amfani da su kauce wa asarar sautin na narkewa kamar fili da kuma mafitsara bayan tiyata, rage intraocular matsa lamba, zai iya haka a yi amfani a ophthalmology. Samfurin Form - allura, allura subcutaneously da 2.1 ml na wani 0.2% bayani. Max a lokaci - 0.004 g, tare da kullum ba fiye da 0.012, da illa - ptyalism, sweating, da kuma gudawa.

Contraindications da amfani ne CHD, dagagge HDL, Bronchial fuka, da kuma sauran hyperkinesias parkinsonism, ciki, zub da jini daga kogon ciki.

"Fiziostigmin" da aka yi amfani da farko a ophthalmic yi, amma zai iya wani lokacin amfani a gastroenterology a cikin hanji paresis. Da miyagun ƙwayoyi allura karkashin fata na 0.5 - 1 ml na wani 0.1% bayani. Matsakaicin adadin da miyagun ƙwayoyi da rana kada wuce 0,001 g

Side effects ne a karfafa salivation, bronchospasm, hanji spasm na tsokoki, da canje-canje a cikin zuciya rate, convulsions.

Contra-alamomi: angina, epilepsy, asma, inji hanji toshewa, peritonitis, sepsis, ciki.

"Galantamine": umarnin don amfani da

"Galantamine" musamman lokuta ake amfani da matsayin antagonist for tsoka relaxants a cikin postoperative zamani tare da wani karu a tsoka sautin na hanji da kuma mafitsara. Contraindications da amfani ne hypersensitivity, epilepsy, asma, jini sama 139/99 mmHg, COPD, inji occlusion na hanji bututu, koda aiki hanawa, shekaru 9 da shekaru. Iyakance ga manufar ciki a lokuta inda m illolin outweigh amfanin. A lokacin lactation, za a iya daukar kwayar cutar zuwa jariri ta hanyar da madara.

Side effects: rage zuciya rate, TTP, AV kawancen, arrythmia, tashin zuciya da amai, zawo, dyspepsia, tsoka spasms, urinary incontinence, haematuria, tsãwa.

Yana iya gudanar subcutaneously, intramuscularly, intravenously, transdermally, da baki. A kashi da aka gyara akayi daban-daban, dangane da tarihin da cutar, da kuma ya kamata a gyara ta hanyar halartar likita. A talakawan kullum kashi na manya - daga 10 zuwa 40 MG, zuwa kashi biyu zuwa hudu allurai.

Wani sabon ƙarni na prokinetics

Bisa yau Itopride nuna kwayoyi kamar "Ganaton", "Itomed", "Pramer". Daya daga cikin sabuwar kuma mafi inganci, sũ ne waɗanda prokinetiki sabon ƙarni a matsayin "koordinaks" da "Prepulsid". Ko da yake za su iya haifar da tsanani illa a cikin zuciya.

A mafi mashahuri a cikin gastroenterologists zauna "Motilium" (aiki sashi - domperidone), wanda hadawa da ingancin metoclopramide, amma ba shi da ta mummunan sakamakon.

Mene ne mafi tasiri pprokinetiki? List of kayayyakin yanzu ya hada da:

1. "Itopride" (aiki sashi) - "Ganaton", "Itomed", "share fage" (kasuwanci sunan).
2. "Metoclopramide" - "Raglan" "Reglan".
3. "Cisapride" - "koordinaks", "Prepulsid".
4. "Domperidone" - "Motilium", "Motilak", "Motinorm", "Passazhiks".

Yanzu mun san cewa irin wannan prokinetic. Lissafa su kamar yadda ka gani, shi ne manya-manyan. Amma ka tuna, kafin yin amfani da wani magani ya kamata shawarci tare da likita! Zauna lafiya!