Da miyagun ƙwayoyi "Leykostim": umarnin don amfani, real takwarorinsu

Mene ne magani "Leykostim"? Umurnai, saki form, alamomi da kuma contraindications ga wannan magani zai iya bayyana a kasa. Mu kuma gaya muku game da abin da analogs suna samuwa ga wannan kayan aiki ne kunshe a abun da ke ciki, da sauransu.

A siffar, marufi, wani ɓangare na miyagun ƙwayoyi

Abin da siffar aikata miyagun ƙwayoyi "Leykostim"? Umarnin don amfani da rahoton cewa aiki medicament ne kerarre a matsayin mafita ga subcutaneous ko igiyar jini gwamnati.

The aiki bangaren na wakili ne filgrastim. Yana da wani recombinant granulocyte mallaka-haramta motsa factor. 1 ml da miyagun ƙwayoyi bayani na iya ƙunsar 300 MG (miliyan 30. Iu), 600 MG (miliyan 60. Iu) ko 150 micrograms (miliyan 15. I.U.) filgrastim.

Amma ga excipients, sa'an nan su yi amfani da matsayin mannitol, sodium acetate trihydrate, dextran, acetic acid, polysorbate, da kuma ruwa ga allura.

A wani marufi bayani ne sayar "Leykostim"? Umurnai na amfani saka a cikin wani kwali akwatin tare da daya ko biyar vials na miyagun ƙwayoyi.

A Properties daga cikin miyagun ƙwayoyi

Mene ne ginshikai na mataki na miyagun ƙwayoyi a "Leykostim"? Umarnin don amfani da likitoci sake dubawa ce cewa shi ne mai magani-immunomodulator. Shi ne mai matuƙar tsarkakakku ba glycosylated gina jiki da cewa yana da wani tsaiko na da tasiri a kan ci gaban da kuma motsi (daga bargo a cikin jini) aikin neutrophils.

Bayan gabatarwa daga cikin miyagun ƙwayoyi muhimmanci ƙara yawan neutrophils a cikin jini, kuma kawai dan kadan - monocytes. Wannan na faruwa a cikin 24 hours.

A karuwa a jini neutrophils ne kashi-dogara. Generation na ilimin aiki da furotin, Ina nufin filgrastim, wanda ya koma daidai da yaduwa da kuma bambance na sel ɗauke da damuwa daga cikin kwayoyin Escherichia coli. Ba zato ba tsammani, da karshen, saboda da damar zamani kayyade aikin injiniya, complemented gene granulocyte mallaka haramta motsa mutum factor.

Bisa ga ka'ida na effects a jiki da miyagun ƙwayoyi ne kama da granulocyte mallaka-haramta motsa factor, wanda shi ne na halitta asali. The kawai bambance-bambance ne facts cewa "Leykostim" (bayani) ba glycosylated, kuma yana da N-m amino acid saura na methionine.

Features da miyagun ƙwayoyi

Abin da siffofin yana da magani "Leykostim"? Umurnai na Amfani furta cewa, ya kamata a yi amfani da ganewar asali neutropenia cikin mutanen da suka sha jiyyar cutar sankara. Har ila yau, wannan magani ne sosai tasiri ga na kullum neutropenia. Wannan shi ne saboda ganin cewa ya ke iya mayar da mafi kyau duka yawan neutrophils a cikin jikin mutum.

Amfani da halitta ga rigakafin, da mãsu haƙuri iya rage da ya faru na neutropenia, kazalika da rage haduwar da ya kwarara da kuma tsawon lokacin da cuta. Irin wannan daukan hotuna hana cututtuka rikitarwa, rage haƙuri tsawon na asibiti Yawara, damar jiyyar cutar sankara ba tare da tafiyarsu daga sharuddan da cewa an kafa janar makirci na magani.

Kamar yadda jikin mutum ya aikata "Leykostim"? Umurnai na amfani nuna cewa yin amfani da miyagun ƙwayoyi taimaka wa shugabanci a gefe jini Kwayoyin kafin hematopoiesis, wanda aka tattara ta cytapheresis (Ina nufin, raba da jini a cikin salon salula bangaren da zabe kau) da kuma gudanar da wani haƙuri bayan wani shakka daga high-kashi jiyyar cutar sankara.

Bi da bi, da allura sel (kara) da ciwon hematopoietic aiki, rage rigakafi da kuma hematopoietic tsarin, kazalika da rage hadarin da tsanani daga cututtuka da kuma hemorrhagic rikitarwa.

magani aminci

Yana da wani hadari ga mutum miyagun ƙwayoyi "Leykostim"? Manual jihohin da wannan magani za a iya amfani da yara da manya. Shi ne daidai da lafiya ga dukkan mutane samun cytotoxic jiyyar cutar sankara.

Marasa lafiya da immunodeficiency virus aikace-aikace bayani na samar da ganiya matakin na neutrophils kuma yana ba da damar bin duk da shawarar dosages na maganin ko myelosuppressive far.

Lokacin amfani da wannan samfurin na HIV kwafi aka kiyaye.

Pharmacokinetics

Abin da pharmacokinetic miyagun ƙwayoyi yana da "Leykostim"? Umarni nuna cewa taro na aiki sashi na wannan wakili ne kai tsaye dogara a kan gudanar kashi.

Bayan subcutaneous gwamnati, mafi girma adadin miyagun ƙwayoyi a cikin jini ya lura bayan kamar 8-15 hours.

A rabin-rai "Leykostima" aiki abu ne uku zuwa hudu. Filgrastim metabolized zuwa peptides. Game 1% na aiki bangaren bayyana canzawa a cikin fitsari.

Filgrastim jari a cikin jikin mutum ba ya faruwa ko bayan shafe tsawon amfani da miyagun ƙwayoyi (a lokacin da far ya wuce wata). A wannan lokaci na rabin rayuwa ne guda.

alamomi

"Leykostim" The magani an wajabta, a cikin wadannan dalilai:

• don rage tsawon na neutropenia kwarara taku 2-4, kuma ma a rage abin da ya faru na febrile neutropenia a cikin mutane tare da marurai nemieloproliferativnymi bayan jiyyar cutar sankara da cytostatic jamiái.
• don rage manifestations na matsalolin da bayyana lokacin da neutropenia, kazalika don rage lokaci Hakika cuta a cikin mutane jurewa myeloablative jiyyar cutar sankara tare da bargo dasawa larura.
• cell destinations gabanin hematopoiesis a gefe jini ga manufar raba da transplanting su bayan myelosuppressive jiyyar cutar sankara.
• domin lura da neutropenia a mutane da HIV (ciki har da waɗanda suke a cikin ci-gaba mataki) domin rage hadarin cututtuka na kwayan asalin;
• domin lura da kullum neutropenia.
• cell yankunan kafin hematopoiesis, a gefe jini na lafiya gudunmawa da za a transplanted da kuma raba su da lafiya.

contraindications

Mene ne contraindications miyagun ƙwayoyi yana da "Leykostim"? Reviews kwararru ruwaito da wadannan haramci:

• ya karu mutum ji na ƙwarai daga mãsu haƙuri ga aiki da kuma sauran sinadaran a cikin abun da ke ciki na miyagun ƙwayoyi.
• nakasar neutropenia, mai tsanani sunã gudãna a tare da cytogenetic cuta (Kostmann ciwo).
• neonatal lokaci (musamman cikin watan farko na rayuwa).

Drug "Leykostim": wa'azi da aikace-aikace

An fito da magani za a iya gudanar a hanyoyi biyu:

• intravenously.
• subcutaneously.

Sashi kuma Hanyar gwamnati "Leykostima" ya kamata a ƙaddara da masana, dangane da halin da ake ciki na asibiti, da mutum halaye na haƙuri da cutar. Duk da haka, ya kamata a lura da cewa likita yi shi an fi son subcutaneous gwamnati da miyagun ƙwayoyi.

Domin igiyar jini aiki medicament aka janye daga vial da sirinji, sa'an nan an kara zuwa vial na 5% dextrose. A sakamakon bayani ne gudanar da wani haƙuri ga rabin awa.

Yaya za a nemi "Leykostim"? Umurnai (analogues wannan magani da za a tattauna a kasa) ya furta cewa, da miyagun ƙwayoyi ya kamata a yi amfani da babu a baya fiye da rana bayan karshen jiyyar cutar sankara.

Da miyagun ƙwayoyi bayani da aka gudanar dangane da haƙuri da nauyi. A kashi jeri na 5-12 MG da 1 kg nauyi. Injections ake yi a kowace rana tare da wani mita na da sau daya a rana.

Far ne dauke da miyagun ƙwayoyi kamata a da za'ayi muddin yawan neutrophils a cikin jini ba su isa al'ada matakan. Yawanci, da magani tsawon shi ne makonni biyu.

A lokacin gwamnatin kwararru da ake bukata a kai a kai ƙayyade yawan leukocytes a cikin jini. Idan lambar ne mafi girma daga 50,000 / microliter, da miyagun ƙwayoyi kife.

A lokacin far, da mãsu haƙuri iya ci gaba thrombocytopenia. A cikin akwati a maimaita kima da platelet count darajar an aje a kasa 100,000 / microliter, sa'an nan ya yi nazarin wucin gadi sokewa da miyagun ƙwayoyi ko rage ta sashi.

illa

Bisa kididdigar da, da miyagun ƙwayoyi "Leykostim" da wuya Yanã m halayen. Duk da haka, zai iya har yanzu taimaka zuwa fitowan da irin wannan illa da kamar:

• dysuria.
• zafi a cikin kasusuwa, ko tsokoki.
• alopecia.
• hepatomegaly, splenomegaly.
• hypotension (dõgẽwa).
• ya karu da matakan uric acid da alkaline phosphatase.
• wani rauni, ciwon kai da kuma gajiya.
• rashin lafiyan halayen a farkon na magani, wanda sau da yawa faruwa bayan igiyar jini gwamnati da miyagun ƙwayoyi.

Ya kamata kuma a lura da cewa a lokacin da wani ba daidai ba allura iya damemu da haƙuri da rashin jin daɗi a cikin allura shafin.

miyagun ƙwayoyi interactions

Kafin yin amfani da wannan magani, dole ne ka gane yadda za a yi mu'amala da wasu magunguna "Leykostim". Umurnai (INN na magani sauti kamar "filgrastim") ya ƙunshi cikakken bayani ta hanyar:

• Medicament "5-FU" Qarfafa neutropenia.
• Saboda girma myeloid Kwayoyin ne musamman m zuwa cytotoxic jamiái, ya nada "Leykostim" ya zama wani yini kafin ko bayan yin amfani da wadannan kwayoyi.
• An sano medicament m tare da sodium chloride.
• Lokacin amfani da mafita ga shugabanci na progenitor Kwayoyin wadannan jiyyar cutar sankara kamata a yi la'akari da cewa ya dace rage-rage a lokacin da wajibi janyo ra'ayoyin jama'a aikace-aikace "carmustine" "Melphalan" da "carboplatin".

takamaiman shawarwari

An ba da shawarar sanya "Leykostim" mutane da sosai hanta aiki da koda, kamar yadda filgrastim lafiya da kuma inganci a wadannan marasa lafiya ba a karatu.

Marasa lafiya da osteoporosis da sauran kashi cuta, suka yi amfani da miyagun ƙwayoyi ci gaba na tsawon watanni shida, ya kamata ka gudanar da iko da kashi yawa.

A tasiri na da miyagun ƙwayoyi a cikin mutane tare da kananan adadin myeloid progenitor Kwayoyin ba a karatu. Duk da haka, masana jayayya cewa a irin wannan marasa lafiya mataki na karuwa a yawan neutrophils iya zama da muhimmanci ƙananan.

Inganci da kuma kariya na "Leykostima" a cikin mutane tare da kullum myeloid cutar sankarar bargo da kuma myelodysplastic ciwo ba a kafa. A wannan connection, a cikin irin cututtuka ba a nuna.

Monotherapy dauke ba miyagun ƙwayoyi hana anemia da kuma thrombocytopenia, wanda ake sa ta myelosuppressive jiyyar cutar sankara. Yana ake bukata domin sanin yawan platelets da hematocrit. Musamman hankali ya kamata a nuna a lokacin da yin amfani da guda-bangaren ko hade da tsoka regimens, an san su da ikon sa mai tsanani thrombocytopenia.

Kafin fara jiyya, "Leykostimom" wajibi ne don yin cikakken bincike na jini tare da wani adadin platelet da leukocyte kirga, da kuma gano da karyotype da kuma bargo hoto.

A lokacin da magani ake bukata a kai a kai saka idanu da fitsari da kuma girman da baƙin ciki.

Drug "Leykostim": analogs da farashin

Analogues kwayoyi suna dauke da wadannan kwayoyi: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Amma ga farashin, sa'an nan "Leykostima" ne sosai high. Saya da wannan magani a Pharmacy a Moscow da wasu birane Rasha iya zama na 2500-4500 rubles. Farashin wannan magani ya dogara da girman da yawan ampoules da fakitin.

magani Reviews

Abin baƙin ciki, da sake dubawa na marasa lafiya da suke yi da wannan magani, sosai kadan. Bisa ga cewa akwai, da magani mafi sau da yawa wajabta tsarin na rigakafi, kazalika da cyclic neutropenia a yara. The sakamako daga cikin miyagun ƙwayoyi a cikin irin wannan tsanani cututtuka ne takaice.

Ya kamata kuma a lura da cewa akwai haƙuri shedu a kan asibiti amfani da "Leykostima" a yara da kuma manya da neutropenia hade da ciwon daji jiyyar cutar sankara. Shiri sanya jariran a wani sashi na 5 MG / kg per day, wajen da kyau jure.

Wasu marasa lafiya da sha'awar da tambaya game da abin da irin bayani ne mafi alhẽri: "Leykostim" ko "Neupogen". A sakamakon gwajinsu da aka za'ayi su gane tolerability da kuma inganci na wadannan jamiái, da wadannan karshe aka kai: deadlines ga gyara da neutropenia bayan yin amfani da magunguna da aka ambata ba rarrabe. Haka kuma, suna da daidai da wannan Manuniya na inganci da kuma tolerability.