Primary sclerosing cholangitis: Bayyanar cututtuka, bincike da kuma magance

Sclerosing cholangitis - wata cuta daga cikin hanta bile ducts a cikin abin da su ganuwar kullum kumburi fara. A sakamakon ta asalin ne matakai sclerosis, m. E. Sauyawa tare da tabo nama. Wannan Pathology yana da wani causal dangantaka da sauran hanta cututtuka, amma sau da yawa take kaiwa zuwa bayyanar rikitarwa daga wannan jiki. A yau labarin, za mu bayyana dalilin da ya sa tasowa sclerosing cholangitis. Alamun da kuma lura da cutar ma za a gabatar da hankalinka.

ilimin Halittar Jiki reference

Bile ne wani muhimmin bangaren da narkewa kamar tsari. Ta aka hannu a cikin rashin lafiya na fats, qara aiki na pancreatic enzymes da kuma stimulates hanginsu. Bile ci gaba da samar da hanta Kwayoyin - hepatocytes. Per rana a sakamakon su m aikin da aka samu game da 1 lita na ruwa. Bayan haka, bile shiga cikin mafitsara da kuma duodenum.

Outflow mugunya shirya ta musamman ducts. Kamar yadda suka zo a cikin intrahepatic da extrahepatic dangane da wuri. A sakamakon m tafiyar matakai, shigar azzakari cikin farji na pathogens ko wasu dalilai, da ducts iya zama inflamed. A lokaci guda magana game da ci gaban irin wannan cututtuka kamar cholangitis. Pathological tsari ko da yaushe yana da wani daban-daban etiology. Saboda haka, an ware wadannan jinsuna: mai guba, kwayan, helminthic, sclerosing. Karshe ne musamman rare, amma halin tsanani.

Sclerosing cholangitis kasu kashi biyu siffofin: firamare da kuma sakandare. Kowace daga cikinsu ne halin da takamaiman sa na bayyanar cututtuka da kuma hanya. A cikin farko idan yana nufin wani kullum cutar da cewa yana tare da cunkoso da bile kuma ba surkin jini kumburi ducts, ga halaka su kuma maye da connective nama. Secondary form Pathology tasowa a karkashin mataki na mai guba abubuwa. A rare lokuta, da ya faru ne ya sa ta kasa jini wadata. A wannan labarin, za mu mayar da hankali a more daki-daki a kan primary bambance-bambancen da cutar.

Brief Description da cutar

Primary sclerosing cholangitis ne classified kamar yadda rare pathologies na biliary tsarin. Bisa ga ilimin kididdiga data, shi ne kamu a daya cikin hudu mutane da dubu 100 yawan jama'a. Inji na ci gaba da cutar rage bayyanar kumburi a cikin kananan hanta ducts. Kamar wancan akwai wani hardening na su. A hankali zoba kuma maras kyau tashoshi ta hanyar abin da bile gudana a cikin kumfa. M matakai amfani da intercellular sarari na hanta, sakamakon cirrhosis.

Ko a karshen karni na karshe shi yiwuwa a gane asali cutar kawai bayan tiyata ko autopsy. Godiya ga ci gaban magani yau rashin lafiya za a iya gano da yawa a baya. Don mafi nisan saukin kamuwa da ita ta hanyar maza masu shekaru 25 zuwa shekaru 40. Wadannan iyakoki ne sosai matukar, saboda cutar na iya zama asymptomatic na dogon lokaci. Wani lokaci da bayyanar cututtuka na kumburi kuskure ga autoimmune cuta, ulcerative colitis da cystic fibrosis.

A Sanadin cholangitis

A daidai Sanadin cutar ne ba a sani ba. Doctors ware kungiyar na abubuwan da ƙara da alama na da ya faru. Daga cikin su akwai:

• kwayoyin predisposition.
• Virus aiki a cikin jiki.
• propensity zuwa autoimmune cututtuka.
• daukan hotuna zuwa mai guba abubuwa.

Daga cikin wadannan dalilai da aka fi bayar da fifiko kwayoyin sunadaran. Ri hujja da wannan al'amari suna da yawa karatu da cutar tsakanin yan uwa.

asibiti hoto

A kan rashin lafiya har shekaru da yawa na iya zama asymptomatic ko da m bayyanar cututtuka. Marasa lafiya sau da yawa ba zai iya ce daidai lokacin da kuma ya bayyana nuna sclerosing cholangitis bayyanar cututtuka. Pathology ana gano ta samu damar ganin likita game da wasu kiwon lafiya matsaloli. A lokacin da lifiya saukar da farko alamar rashin lafiya - ƙara rates na hanta enzymes.

Kamar yadda cutar progresses da kuma na asibiti hoto canje-canje. Daga cikin babban bayyanar cututtuka na wadannan dole ne a alama:

• gajiya, m sleepiness.
• matalauta ci.
• yellowing na mucous membranes da kuma fata.
• kiwon da yawan zafin jiki zuwa subfebrile dabi'u;
• aching jin zafi a dama subcostal yankin, har ya zuwa wuyansa, ko kafada.
• itching.
• mahara xanthomas.
• rashin jin daɗi a hagu na sama quadrant, sakamakon daga kara girma daga cikin baƙin ciki.
• inganta pigmentation na fata.

Wani lokaci, na farko sclerosing cholangitis bi kumburi hanji cuta. Wadannan sun hada da ulcerative colitis, Crohn ta cuta.

hanyoyin da ganewar asali

Idan ka zargin wani cuta ya kamata nan da nan nemi taimako daga likita. Jarrabawa na haƙuri fara da binciken na ta tarihi, gunaguni da farko bayyanar cututtuka. Bayan da cewa, ci gaba na zahiri jarrabawa. A haƙuri iya zama scratches a kan fata, mai tsanani jaundice. Palpation ne yawanci samu wata karuwa da hanta da saifa.

Domin tabbatar da farko ganewar asali na haƙuri aiko domin kara jarrabawa. Yana hada da wadannan ayyukan:

• jini gwajin (a wuce haddi na Manuniya na leukocytes da ESR nuna kumburi).
• Ciki duban dan tayi.
• elastography hanta (damar kimanta jiki elasticity).
• retrograde cholangiopancreatography (radiography amfani da bambanci).
• jini Biochemistry (a primary sclerosing cholangitis lura wuce kima hanta enzymes).
• MRI.
• Hanta biopsy (wannan hanyar bincike taimaka wajen gano wuraren fibrosis).

Wadannan hanyoyin da damar binciken don tabbatar da primary sclerosing cholangitis. Ganewar asali da cutar ila yau, taimaka ƙayyade tsanani daga cikin pathological tsari. A total akwai hudu:

1. Portal. An halin bayyanar puffiness da hanta fibrosis ducts.
2. Periportal. Bayyanar cututtuka na mataki na farko ne complemented wata mafi pronounced fibrosis da kuma lalata tafiyar matakai ducts.
3. Septal. A wannan mataki da cutar akwai farko ãyõyin cirrhosis.
4. Cirrhotic. Halin da cikakken fledged ci gaban biliary cirrhosis.

Bisa ga sakamakon da hadaddun jarrabawa likita ta zayyana far.

magani Jagororin

Far a wannan cuta ne da nufin kama da kumburi tsari, da dawo da bile kwarara da kuma detoxification na jiki. Don wannan karshen, da ra'ayin mazan jiya da kuma gudanar da hanyoyin magani amfani a zamani magani. A cikin farko idan yana nufin magani da kuma riko da wani m rage cin abinci. Surgery aka nuna a mai tsanani lokuta, a lokacin da masu ra'ayin mazan jiya jiyya zai kasa. Selection na wani musamman Hanyar magani ne up ga likita.

Da amfani da kwayoyi

Dangane da tsananin daga cikin cuta, shi za a iya sanya gado sauran kuma cire duk wani motsa jiki. Idan wani haƙuri ne damu game da ciwo mai tsanani, ya wajabta antispasmodics ( "Babu-dima jiki", "Spasmobru").

Don dakatar da kumburi tsari taimaka da wadannan kwayoyi:

1. Immunosuppressants ( "Azathioprine"). Sun hana na ayyuka na rigakafi da tsarin.
2. Antifibrogennye nufi. Su main mataki ne da nufin kawar da fibrosis, da kuma rigakafin da kara ci gaba.
3. Glucocorticosteroid hormone ( "Prednisolone"). Sun taimaka wajen rage kumburi.

A amfani da wadannan magunguna damar cin nasara da farko mataki na ci gaba da firamare sclerosing cholangitis. Bayyanar cututtuka da cutar sau da yawa hana gubar al'ada rayuwa ga marasa lafiya. Itchy fata, narkewa kamar fili da matsaloli da kuma dyspepsia - duk wadannan keta da wani mummunan tasiri a kan su kiwon lafiya. Saboda haka bugu da žari sanya symptomatic far. Yana hada samun hanta ( "Essentiale"), na ciki da enzymes ( "Creon") da kuma magunguna domin kawar da itching. Kwayoyi suna da yaushe zabi akayi daban-daban, shan la'akari da sauran asibiti hoto da kuma haƙuri da yanayin.

rage cin abinci Features

Marasa lafiya da aka kasaftawa ga ikon "tebur lamba 5". Lokacin da wannan rage cin abinci ya kamata iyakance amfani da m, soyayyen da yaji jita-jita. Dabba fats ne fin so don maye gurbin shuka. Bugu da kari, shi wajibi ne don gaba daya kashe daga cikin abinci irin kek da sweets, m 'ya'yan itatuwa da kuma berries, cakulan, barasa, nama da kuma marinades.

Izni ne ba don amfani da ramammu nama / kifi, wasu iri gurasa, porridge a kan ruwa. Zaka kuma iya ci kiwo kayayyakin, zuma, taliya soups kayan lambu broth.

Lokacin da ganewar asali "primary sclerosing cholangitis" magani da magani da kuma rage cin abinci yana ba da sakamakon tabbatacce ne kawai a farko. Idan wannan lokaci da aka rasa, zai bukaci tiyata.

m baki

Conservative hanyoyin kwantar da hankali a yi amfani da uncomplicated siffofi na pathological tsari. Ko dace tunani da likita ba ko da yaushe ba wani sakamakon tabbatacce a cikin hali na m far. Lokacin da magani da kwayoyi ba ya haifar da daidaita yanayin ko kasa maido da na yanzu na bile, koma ga m baki.

Yau likitoci fi son endoscopic ayyukan. Sun bayar da shawarar yin duk jan ta hanyar kananan incisions a cikin fata. Duk da haka, irin wannan hanyoyin ne a mafi yawan lokuta ba a gajere sakamako da kuma ne fraught tare da rikitarwa. Kuma gudanar da balan-balan dilatation da stenting ducts. A lokacin da hanya, da likita shimfida tashoshi na musamman cylinders da kuma kafa raga, hana su daga takaita. Idan akwai da za a kaddamar sclerosing cholangitis, hanta dashi magani nufi.

zai yiwu rikitarwa

A cutar halin da jinkirin kwarara. Yana amsa talauci to far, da kuma yawan tsari bayyananen kawai aggravates tsari. Daga cikin mafi kowa rikitarwa daga gare su da wadannan:

1. Portal hauhawar jini. Wannan Pathology yana tare da wani karuwa a matsa lamba a cikin hanta jini ya kwarara. Its main bayyanuwar aka dauke ascites.
2. Cholestasis ciwo. A kan backdrop na hardening na bile ducts hankali taper a giciye-sosai. Wannan ya bayyana bayyanar jaundice da pruritus. Kamar yadda da ci gaban da cutar lumen Narrows ƙara. Steatorrhea ya auku, wanda yana tare da osteoporosis.
3. Kwayan sclerosing cholangitis hanta.
4. Kullum pancreatitis.
5. Holangiokartsionoma (ƙari bile ducts).
6. Cholelithiasis.

Irin wannan rikitarwa da faruwa a cikin 3-4 mataki na pathological tsari.

Hasashen da kuma rigakafin matakan

Primary sclerosing cholangitis ne classified kamar yadda sannu a hankali ci gaba cuta. Ya sakamakon a mafi yawan lokuta shi ne na kullum hanta gazawar. Abu mai muhimmanci worsen da hangen nesa ci gaba shekaru na haƙuri, gaban concomitant pathologies daga cikin hanji, da ya faru na da rikitarwa. Yawanci, tare da bayyanar da farko ãyõyin cuta kafin karshe mataki kara daga 7 zuwa 12 shekaru.

Shin yana yiwuwa a hana primary sclerosing cholangitis? Reviews na likitoci sun ce saboda kasa nazari na musamman rigakafin cutar ba a ci gaba.