Umurnai na amfani - ampicillin

Quite a yayin da suka wuce, shi ya zama sananne cewa babban inji na adaptability na daban-daban na kwayoyin maganin rigakafi ne β-lactamase da su kayayyakin. Su ne sosai tasiri a bayar da tasu gudunmuwar da halakar da m zobba maganin rigakafi da kuma kusan soke su warkewa sakamako. Don shawo kan wannan mummunan sakamako, an ci gaba da kusan shirya sinadaran mahadi da cewa inactivate β-lactamase ne da farko clavulanic acid formulations sulbactam da tazobactam.

Wadannan mahadi hada da yadda abubuwa na abin da ake kira penicillin ingibitorozaschischonnyh - hade da kwayoyi, wanda sun hada da penicillin da kwayoyin. Yadu da aka sani misalai na irin shirye-shirye ne ampicillin-sulbactam, amoxicillin, ticarcillin da sauransu da ke cikin kungiyar na penicillins. Su yi amfani da shi ne tasiri kuma saboda za su iya aiki a matsayin wani ɓangare na wani m iri-iri na haduwa da da cephalosporin na III tsara, yayin da tasiri na aiki sashi tsaya a wani babban matakin.

A lokacin daban-daban haduwa, ana amfani da yawa zamani kwayoyi hada da wani abun da ke ciki maganin rigakafi da kuma hanawa na β-lactamase, akwai wani primary aiki farfadowa penicillins kuma suna kusan gama gano su warkewa inganci a wajen magance mafi yawan da aka sani na staphylococci yau anaerobes da gram kwayoyin. Bugu da kari, a cikin irin wannan formulations aka fadada su antimicrobial bakan. Irin wannan magani nasa ne ampicillin / sulbactam, wanda dangane da manufacturer iya har yanzu a iya samar karkashin sunayen ko unazin Sulatsillin.

Wannan magani hada ampicillin da sulbactam, waxanda suke da ba a wani rabo daga 2: 1. Kamar yadda aka nuna ta umurci manual, ampicillin da sulbactam a cikin wannan shiri fãce zahiri tarewa β-lactamases da fairly pronounced aiki da Neisserial da atsinetobakterov.

Yawancin lokaci domin ciki miyagun ƙwayoyi samun sanya sultamicillin, hada da sulbactam da ampicillin. Allunan lokacin samun tunawa a cikin jiki. Sa'an nan da dauki hydrolysis da kuma hada sakamako hada da miyagun ƙwayoyi ampicillin da sulbactam, wanda kara habaka bioavailability na ampicillin har ma mafi girma matakin da aka kai a lokacin da samun wani daidaita kashi na gargajiya ampicillin.

Quite mai fadi bakan na aiki, da kuma wannan miyagun ƙwayoyi. Saboda haka, amfani da mafi kwayoyi da aka nuna a cikin cututtuka na kwayan asalin TTP, sinusitis daban-daban siffofi da kuma etiology. A magani aka wajabta a cututtuka na ƙananan numfashi fili: na kullum mashako, ciwon huhu.

A cewar umarnin don amfani, ampicillin da sulbactam abun ciki shi ne tasiri a lura da siffofin daban-daban na intraabdominal da pelvic cututtuka, ciki har da taushi nama kamuwa da cutar, kashi da kuma hadin gwiwa cututtuka, septicemia.

A shirye-shiryen da ampicillin da sulbactam muhimmanci mafi tasiri idan aka kwatanta da amoxicillin / clavulanate da magani daga cututtuka da aka qaddamar da atsinetobakterom.

A sashi daga cikin miyagun ƙwayoyi kayyade umarnin don amfani. Ampicillin An wajabta baki, da kashi na manya ne a 0,375-0,75 grams ko da kuwa da abinci sau biyu a lokacin da rana, idan cutar ne sauki hali. A mafi tsanani siffofin da magani amfani da 1.5-3.0 grams ko'ina cikin yini a lokacin da mai tsanani da aka kara, da sashi za a iya ƙara zuwa 6.0 grams.

Babies miyagun ƙwayoyi gudanar a allurai lasafta game da 50 micrograms da rana ta daya kilogram na nauyi na yaro. Kudin shiga ne da za'ayi sau biyu.

Saki tsari da kuma sashi daga cikin miyagun ƙwayoyi da cikakken kwatanci na umarnin don amfani. Ampicillin kuma za a iya dauka, sai dai alluna a cikin nau'i na foda amfani da shirya da musamman dakatar (idan baki gudanar). Kuma bayar da yin amfani da miyagun ƙwayoyi da allura, domin wannan shi ne samar a foda siffan. A sauran ƙarfi kawota tare da miyagun ƙwayoyi a guda kunshin.